gpDB: a database of G-proteins and their interaction with GPCRs
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gpDB::G-protein View
Entry 1 of 1 :: GPR0002 ::
CLASS Galpha
FAMILY Gq/11
SUBFAMILY Galpha-q
TYPE Galpha-q

Cross References:
UniProt Q6NT27 EMBL BC057777 | BC067850 | BC069520 | BC075096 | BC075097 | CH471089
InterPro IPR001019 | IPR000654 | IPR011025
PRODOM PD000281
GENEID 2776
PRINTS PR00318 | PR00442 PFAM PF00503

Details:
NAME Galpha-q-Homo sapiens-2
DESCRIPTION Guanine nucleotide binding protein (G protein), q polypeptide (Guaninenucleotide binding protein (G protein), q polypeptide, isoform CRA_c).
SPECIES Homo sapiens COMMON NAME Human NCBI Taxonomy 9606
POST TRANSLATION MODIFICATIONS null GENE GNAQ | hCG_1984513
SEQUENCE 
MTLESIMACCLSEEAKEARRINDEIERQLRRDKRDARRELKLLLLGTGESGKSTFIKQMR
IIHGSGYSDEDKRGFTKLVYQNIFTAMQAMIRAMDTLKIPYKYEHNKAHAQLVREVDVEK
VSAFENPYVDAIKSLWNDPGIQECYDRRREYQLSDSTKYYLNDLDRVADPAYLPTQQDVL
RVRVPTTGIIEYPFDLQSVIFRMVDVGGQRSERRKWIHCFENVTSIMFLVALSEYDQVLV
ESDNENRMEESKALFRTIITYPWFQNSSVILFLNKKDLLEEKIMYSHLVDYFPEYDGPQR
DAQAAREFILKMFVDLNPDSDKIIYSHFTCATDTENIRFVFAAVKDTILQLNLKEYNLV
 FRAGMENT NO
FUNCTION -
Effectors:
1EFF0117Burton's tyrosine kinase-Homo sapiens-1Stimulation (indirect stimulation of p38 MAPK)15251227 | 9305846 | 16182515
2EFF0118Burton's tyrosine kinase-Homo sapiens-2Stimulation (indirect stimulation of p38 MAPK)15251227 | 9305846 | 16182515
3EFF0120Burton's tyrosine kinase-Homo sapiens-3Stimulation (indirect stimulation of p38 MAPK)15251227 | 9305846 | 16182515
4EFF0121Burton's tyrosine kinase-Homo sapiens-4Stimulation (indirect stimulation of p38 MAPK)15251227 | 9305846 | 16182515
5EFF0122Burton's tyrosine kinase-Homo sapiens-5Stimulation (indirect stimulation of p38 MAPK)15251227 | 9305846 | 16182515
6EFF0123Burton's tyrosine kinase-Homo sapiens-6Stimulation (indirect stimulation of p38 MAPK)15251227 | 9305846 | 16182515
7EFF0124Burton's tyrosine kinase-Homo sapiens-7Stimulation (indirect stimulation of p38 MAPK)15251227 | 9305846 | 16182515
8EFF0125Burton's tyrosine kinase-Homo sapiens-8Stimulation (indirect stimulation of p38 MAPK)15251227 | 9305846 | 16182515
9EFF0291Caveolin-1-Homo sapiens-1Gq Binds Caveolin to Concentrate in Caveolae16182515 | 11251080
10EFF0292Caveolin-1-Homo sapiens-2Gq Binds Caveolin to Concentrate in Caveolae16182515 | 11251080
11EFF0335EBP50/NHERF-1-Homo sapiensInhibits PLC-beta activation and blocks Gqa-induce Tph and CXCR4 receptor internalization16182515
12EFF0350GRK2-Homo sapiensInhibits PLC-beta activation and blocks Gqa-mediated GLUT4 translocation and glucose uptake in 3T3 adipocytes15251227 | 14654303 | 16182515
13EFF0359GRK3-Homo sapiens-1Stimulation15251227 | 14654303 | 16182515
14EFF0360GRK3-Homo sapiens-2Stimulation15251227 | 14654303 | 16182515
15EFF0397Kir 3.1(GIRK1)-Homo sapiens-1Inhibition12661754
16EFF0398Kir 3.1(GIRK1)-Homo sapiens-2Inhibition12661754
17EFF0410Kir 3.2(GIRK2)-Homo sapiensInhibition12661754
18EFF0420Kir 3.3(GIRK3)-Homo sapiensInhibition12661754
19EFF0425Kir 3.4(GIRK4)-Homo sapiens-1Inhibition12661754
20EFF0426Kir 3.4(GIRK4)-Homo sapiens-2Inhibition12661754
21EFF0434LARG RhoGEF-Homo sapiens-1Stimulation (indirect activation of Rho)15251227 | 12024019
22EFF0435LARG RhoGEF-Homo sapiens-2Stimulation (indirect activation of Rho)15251227 | 12024019
23EFF0442Lbc RhoGEF-Homo sapiensNo functional effects identified16182515
24EFF0443p115 RhoGEF-Homo sapiensNo data1525227 | 16182515
25EFF0444PDZ RhoGEF-Homo sapiens-1No data1525227 | 16182515
26EFF0445PDZ RhoGEF-Homo sapiens-2No data1525227 | 16182515
27EFF0517Phospholipase C beta-1-Homo sapiens-1Stimulation of PLC-beta catalytic activity15251227 | 16182515 | 11015615
28EFF0521Phospholipase C beta-1-Homo sapiens-2Stimulation of PLC-beta catalytic activity15251227 | 16182515 | 11015615
29EFF0522Phospholipase C beta-1-Homo sapiens-3Stimulation of PLC-beta catalytic activity15251227 | 16182515 | 11015615
30EFF0530Phospholipase C beta-2-Homo sapiens-1Stimulation of PLC-beta catalytic activity15251227 | 16182515 | 11015615
31EFF0531Phospholipase C beta-2-Homo sapiens-2Stimulation of PLC-beta catalytic activity15251227 | 16182515 | 11015615
32EFF0541Phospholipase C beta-3-Homo sapiens-1Stimulation of PLC-beta catalytic activity15251227 | 16182515 | 11015615
33EFF0542Phospholipase C beta-3-Homo sapiens-2Stimulation of PLC-beta catalytic activity15251227 | 16182515 | 11015615
34EFF0556Phospholipase C beta-4-Homo sapiens-1Stimulation of PLC-beta catalytic activity15251227 | 16182515 | 11015615
35EFF0558Phospholipase C beta-4-Homo sapiens-2Stimulation of PLC-beta catalytic activity15251227 | 16182515 | 11015615
36EFF0560Phospholipase C beta-4-Homo sapiens-3Stimulation of PLC-beta catalytic activity15251227 | 16182515 | 11015615
37EFF0572PI3K alpha-Homo sapiensInhibition of PI3K kinase activity in vitro16182515
38EFF0577PI3K beta-Homo sapiens-1Inhibition of PI3K kinase activity in vitro16182515
39EFF0578PI3K beta-Homo sapiens-2Inhibition of PI3K kinase activity in vitro16182515
40EFF0586PI3K gamma-Homo sapiensInhibition of PI3K kinase activity in vitro16182515
41EFF0595Protein kinase D-Homo sapiensStimulation10636921
42EFF0874Synembryn(Ric8a)-Homo sapiensStimulates Gqa activation and steady-state GTPase activity in vitro16182515 | 12509430
43EFF0877TRP repeat protein-1-Homo sapiensG16a co-expression enhances TPR1 interaction with Ras16182515 | 12748287
44EFF1126Tubulin-Homo sapiens-1Potentiates receptor-induced PLC-beta activation16182515
45EFF1127Tubulin-Homo sapiens-10Potentiates receptor-induced PLC-beta activation16182515
46EFF1128Tubulin-Homo sapiens-11Potentiates receptor-induced PLC-beta activation16182515
47EFF1129Tubulin-Homo sapiens-12Potentiates receptor-induced PLC-beta activation16182515
48EFF1130Tubulin-Homo sapiens-13Potentiates receptor-induced PLC-beta activation16182515
49EFF1131Tubulin-Homo sapiens-14Potentiates receptor-induced PLC-beta activation16182515
50EFF1132Tubulin-Homo sapiens-15Potentiates receptor-induced PLC-beta activation16182515
51EFF1133Tubulin-Homo sapiens-16Potentiates receptor-induced PLC-beta activation16182515
52EFF1134Tubulin-Homo sapiens-17Potentiates receptor-induced PLC-beta activation16182515
53EFF1135Tubulin-Homo sapiens-18Potentiates receptor-induced PLC-beta activation16182515
54EFF1136Tubulin-Homo sapiens-19Potentiates receptor-induced PLC-beta activation16182515
55EFF1137Tubulin-Homo sapiens-2Potentiates receptor-induced PLC-beta activation16182515
56EFF1138Tubulin-Homo sapiens-20Potentiates receptor-induced PLC-beta activation16182515
57EFF1139Tubulin-Homo sapiens-21Potentiates receptor-induced PLC-beta activation16182515
58EFF1140Tubulin-Homo sapiens-22Potentiates receptor-induced PLC-beta activation16182515
59EFF1141Tubulin-Homo sapiens-23Potentiates receptor-induced PLC-beta activation16182515
60EFF1143Tubulin-Homo sapiens-25Potentiates receptor-induced PLC-beta activation16182515
61EFF1144Tubulin-Homo sapiens-26Potentiates receptor-induced PLC-beta activation16182515
62EFF1145Tubulin-Homo sapiens-27Potentiates receptor-induced PLC-beta activation16182515
63EFF1146Tubulin-Homo sapiens-28Potentiates receptor-induced PLC-beta activation16182515
64EFF1148Tubulin-Homo sapiens-3Potentiates receptor-induced PLC-beta activation16182515
65EFF1149Tubulin-Homo sapiens-30Potentiates receptor-induced PLC-beta activation16182515
66EFF1150Tubulin-Homo sapiens-31Potentiates receptor-induced PLC-beta activation16182515
67EFF1151Tubulin-Homo sapiens-32Potentiates receptor-induced PLC-beta activation16182515
68EFF1152Tubulin-Homo sapiens-33Potentiates receptor-induced PLC-beta activation16182515
69EFF1153Tubulin-Homo sapiens-34Potentiates receptor-induced PLC-beta activation16182515
70EFF1154Tubulin-Homo sapiens-35Potentiates receptor-induced PLC-beta activation16182515
71EFF1156Tubulin-Homo sapiens-37Potentiates receptor-induced PLC-beta activation16182515
72EFF1157Tubulin-Homo sapiens-38Potentiates receptor-induced PLC-beta activation16182515
73EFF1158Tubulin-Homo sapiens-39Potentiates receptor-induced PLC-beta activation16182515
74EFF1159Tubulin-Homo sapiens-4Potentiates receptor-induced PLC-beta activation16182515
75EFF1160Tubulin-Homo sapiens-40Potentiates receptor-induced PLC-beta activation16182515
76EFF1162Tubulin-Homo sapiens-42Potentiates receptor-induced PLC-beta activation16182515
77EFF1163Tubulin-Homo sapiens-43Potentiates receptor-induced PLC-beta activation16182515
78EFF1164Tubulin-Homo sapiens-44Potentiates receptor-induced PLC-beta activation16182515
79EFF1165Tubulin-Homo sapiens-45Potentiates receptor-induced PLC-beta activation16182515
80EFF1166Tubulin-Homo sapiens-46Potentiates receptor-induced PLC-beta activation16182515
81EFF1167Tubulin-Homo sapiens-47Potentiates receptor-induced PLC-beta activation16182515
82EFF1168Tubulin-Homo sapiens-48Potentiates receptor-induced PLC-beta activation16182515
83EFF1169Tubulin-Homo sapiens-49Potentiates receptor-induced PLC-beta activation16182515
84EFF1170Tubulin-Homo sapiens-5Potentiates receptor-induced PLC-beta activation16182515
85EFF1171Tubulin-Homo sapiens-50Potentiates receptor-induced PLC-beta activation16182515
86EFF1173Tubulin-Homo sapiens-52Potentiates receptor-induced PLC-beta activation16182515
87EFF1174Tubulin-Homo sapiens-51Potentiates receptor-induced PLC-beta activation16182515
88EFF1175Tubulin-Homo sapiens-41Potentiates receptor-induced PLC-beta activation16182515
89EFF1176Tubulin-Homo sapiens-36Potentiates receptor-induced PLC-beta activation16182515
90EFF1177Tubulin-Homo sapiens-29Potentiates receptor-induced PLC-beta activation16182515
91EFF1178Tubulin-Homo sapiens-24Potentiates receptor-induced PLC-beta activation16182515
92EFF1179Tubulin-Homo sapiens-6Potentiates receptor-induced PLC-beta activation16182515
93EFF1180Tubulin-Homo sapiens-7Potentiates receptor-induced PLC-beta activation16182515
94EFF1181Tubulin-Homo sapiens-8Potentiates receptor-induced PLC-beta activation16182515
95EFF1182Tubulin-Homo sapiens-9Potentiates receptor-induced PLC-beta activation16182515

Coupling with GPCRs:
1GPCR00705-HYDROXYTRYPTAMINE RECEPTOR_5-HT-2A_Homo sapiens1765383
2GPCR00825-HYDROXYTRYPTAMINE RECEPTOR_5-HT-2B_Homo sapiens8786115
3GPCR00845-HYDROXYTRYPTAMINE RECEPTOR_5-HT-2C_Homo sapiens1302605
4GPCR0200ADRENOCEPTOR (A1-ADRENOCEPTOR)_A1A(Adrenoceptor)_Homo sapiens-68396931
5GPCR0213ADRENOCEPTOR (A1-ADRENOCEPTOR)_A1A(Adrenoceptor)_Homo sapiens-38396931
6GPCR0215ADRENOCEPTOR (A1-ADRENOCEPTOR)_A1A(Adrenoceptor)_Homo sapiens-48396931
7GPCR0223ADRENOCEPTOR (A1-ADRENOCEPTOR)_A1B(Adrenoceptor)_Homo sapiens1662393
8GPCR0230ADRENOCEPTOR (A1-ADRENOCEPTOR)_A1D(Adrenoceptor)_Homo sapiens-11656955
9GPCR0232ADRENOCEPTOR (A2-ADRENOCEPTOR)_A2A(Adrenoceptor)_Homo sapiens8662784
10GPCR0414ANGIOTENSIN RECEPTOR_AT1_Homo sapiens-18865167
11GPCR0429ANGIOTENSIN RECEPTOR_AT1_Homo sapiens-28865167
12GPCR0459BRADYKININ RECEPTOR_B1_Homo sapiens1657928
13GPCR0467BRADYKININ RECEPTOR_B2_Homo sapiens1657928
14GPCR0449BOMBESIN RECEPTOR_BB1_Homo sapiens8531502
15GPCR0450BOMBESIN RECEPTOR_BB2_Homo sapiens8531502
16GPCR0453BOMBESIN RECEPTOR_BB3_Homo sapiens8383682
17GPCR0995LEUKOTRIENE RECEPTOR_BLT_Homo sapiens-29177352
18GPCR0996LEUKOTRIENE RECEPTOR_BLT_Homo sapiens-19177352
19GPCR2577CALCITONIN, AMYLIN, CGRP, AND ADRENOMEDULIN RECEPTOR_CALCITONIN_Homo sapiens8732687
20GPCR2640EXTRACELLULAR CALCIUM-SENSING RECEPTOR_CASR_Homo sapiens8255296
21GPCR0737CHOLECYSTOKININ AND GASTRIN RECEPTOR_CCK1_Homo sapiens8503909
22GPCR0745CHOLECYSTOKININ AND GASTRIN RECEPTOR_CCK2_Homo sapiens1280419
23GPCR2580CALCITONIN, AMYLIN, CGRP, AND ADRENOMEDULIN RECEPTOR_CGRP_Homo sapiens2536720
24GPCR0997LEUKOTRIENE RECEPTOR_CYSLT-1_Homo sapiens10391245
25GPCR1002LEUKOTRIENE RECEPTOR_CYSLT-2_Homo sapiens10913337
26GPCR2422PROSTANOID RECEPTOR_EP1_Homo sapiens8253813
27GPCR2432PROSTANOID RECEPTOR_EP3_Homo sapiens11095474
28GPCR0814ENDOTHELIN RECEPTOR_ET-A_Homo sapiens1849646
29GPCR0818ENDOTHELIN RECEPTOR_ET-B_Homo sapiens1848367
30GPCR2440PROSTANOID RECEPTOR_FP_Homo sapiens8300593
31GPCR2732FRIZZLED_Frizzled-1_Homo sapiens11563835
32GPCR2738FRIZZLED_Frizzled-2_Homo sapiens11563835
33GPCR0835GALANIN RECEPTOR_GAL2_Homo sapiens9685625
34GPCR0900GONADOTROPIN-RELEASING HORMONE RECEPTOR_GNRH1_Homo sapiens1333190
35GPCR0910GONADOTROPIN-RELEASING HORMONE RECEPTOR_GNRH2_Homo sapiens1333190
36GPCR2606GROWTH HORMONE RELEASING PEPTIDES RECEPTOR_Growth hormone secretagogue receptor type 1(Ghrelin receptor)_Homo sapiens8688086
37GPCR0968HISTAMINE RECEPTOR_H1_Homo sapiens1722337
38GPCR1007LYSOPHOSPHOLIPID RECEPTOR_LPA1_Homo sapiens9600933
39GPCR1013LYSOPHOSPHOLIPID RECEPTOR_LPA2_Homo sapiens9525886
40GPCR1015LYSOPHOSPHOLIPID RECEPTOR_LPA3_Homo sapiens-112215548
41GPCR1018LYSOPHOSPHOLIPID RECEPTOR_LPA3_Homo sapiens-212215548
42GPCR2408LYSOPHOSPHOLIPID RECEPTOR_LPA4_Homo sapiens12724320
43GPCR0871GLYCOPROTEIN HORMONE RECEPTOR_LSH RECEPTOR_Homo sapiens1516719
44GPCR0116ACETYLCHOLINE RECEPTOR (MUSCARINIC)_M1_Homo sapiens-13037705
45GPCR0120ACETYLCHOLINE RECEPTOR (MUSCARINIC)_M1_Homo sapiens-23037705
46GPCR0139ACETYLCHOLINE RECEPTOR (MUSCARINIC)_M3_Homo sapiens-211242080
47GPCR0142ACETYLCHOLINE RECEPTOR (MUSCARINIC)_M3_Homo sapiens-111242080
48GPCR0162ACETYLCHOLINE RECEPTOR (MUSCARINIC)_M5_Homo sapiens3037705
49GPCR2791MELANIN-CONCENTRATING HORMONE RECEPTOR_MCHR1_Homo sapiens10559938
50GPCR2792MELANIN-CONCENTRATING HORMONE RECEPTOR_MCHR2_Homo sapiens11274220 | 11355873 | 11562423
51GPCR2649GLUTAMATE RECEPTOR (METABOTROPIC)_MGLU1_Homo sapiens9076744
52GPCR2658GLUTAMATE RECEPTOR (METABOTROPIC)_MGLU5_Homo sapiens7908515
53GPCR1236NEUROMEDIN RECEPTOR_Neuromedin U 2_Homo sapiens-110894543
54GPCR2502TACHYKININ RECEPTOR_NK1_Homo sapiens1370820
55GPCR2504TACHYKININ RECEPTOR_NK2_Homo sapiens-11370820
56GPCR2509TACHYKININ RECEPTOR_NK2_Homo sapiens-21370820
57GPCR2513TACHYKININ RECEPTOR_NK3_Homo sapiens1370820
58GPCR1274NEUROTENSIN RECEPTOR_NTS1_Homo sapiens8381365
59GPCR1278NEUROTENSIN RECEPTOR_NTS2_Homo sapiens8647296
60GPCR2365OREXIN RECEPTOR_Orexin 1_Homo sapiens9491897
61GPCR2370OREXIN RECEPTOR_Orexin 2_Homo sapiens9491897
62GPCR2555VASOPRESSIN AND OXYTOCIN RECEPTOR_OT_Homo sapiens1313946
63GPCR2377P2Y RECEPTOR_P2Y1_Homo sapiens-28159738
64GPCR2378P2Y RECEPTOR_P2Y1_Homo sapiens-18159738
65GPCR2381P2Y RECEPTOR_P2Y11_Homo sapiens9405388
66GPCR2394P2Y RECEPTOR_P2Y2_Homo sapiens8159738
67GPCR2399P2Y RECEPTOR_P2Y4_Homo sapiens9396022
68GPCR2405P2Y RECEPTOR_P2Y6_Homo sapiens7592819
69GPCR2621VASOACTIVE INTESTINAL PEPTIDE AND PITUITARY ADENYLATE CYCLASE ACTIVATING PEPTIDE RECEPTOR_PAC1_Homo sapiens8396727
70GPCR2454PROTEASE-ACTIVATED RECEPTOR_PAR1_Homo sapiens10644723
71GPCR2461PROTEASE-ACTIVATED RECEPTOR_PAR2_Homo sapiens15082510
72GPCR2463PROTEASE-ACTIVATED RECEPTOR_PAR3_Homo sapiens15082510
73GPCR2467PROTEASE-ACTIVATED RECEPTOR_PAR4_Homo sapiens15082510
74GPCR2412PLATELET ACTIVATING FACTOR (PAF) RECEPTOR_PLATELET ACTIVATING FACTOR (PAF) RECEPTOR_Homo sapiens7876256
75GPCR2415PROLACTIN RELEASING PEPTIDE RECEPTOR (PRRPR)_PrRP_Homo sapiens11030716
76GPCR1090LYSOPHOSPHOLIPID RECEPTOR_S1P2_Homo sapiens10617617
77GPCR1097LYSOPHOSPHOLIPID RECEPTOR_S1P3_Homo sapiens9409733
78GPCR1098LYSOPHOSPHOLIPID RECEPTOR_S1P4_Homo sapiens10679247
79GPCR2449PROSTANOID RECEPTOR_TP_Homo sapiens8300593
80GPCR2522THYROTROPIN-RELEASING HORMONE RECEPTOR_TRH1_Homo sapiens2175902
81GPCR0886GLYCOPROTEIN HORMONE RECEPTOR_TSH RECEPTOR_Homo sapiens-28552586
82GPCR0887GLYCOPROTEIN HORMONE RECEPTOR_TSH RECEPTOR_Homo sapiens-18552586
83GPCR0889GLYCOPROTEIN HORMONE RECEPTOR_TSH RECEPTOR_Homo sapiens-38552586
84GPCR2551UROTENSIN RECEPTOR_UROTENSIN II RECEPTOR_Homo sapiens10499587
85GPCR2559VASOPRESSIN AND OXYTOCIN RECEPTOR_V1A_Homo sapiens1560825
86GPCR2564VASOPRESSIN AND OXYTOCIN RECEPTOR_V1B_Homo sapiens11091117
87GPCR1242NEUROPEPTIDE Y RECEPTOR_Y1_Homo sapiens1321422



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athina University of Athens
 Faculty of Biology
 Dept. of Cell Biology and Biophysics
Biophysics
& Bioinformatics
Laboratory