gpDB: a database of G-proteins and their interaction with GPCRs
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gpDB::GPCR View
Entry 1 of 1 :: GPCR2412 ::
CLASS CLASS A (RHODOPSIN LIKE)
FAMILY PLATELET ACTIVATING FACTOR (PAF) RECEPTOR
SUBFAMILY PLATELET ACTIVATING FACTOR (PAF) RECEPTOR

Cross References:
UniProt P25105 | A3KMC8 EMBL M80436 | D10202 | M76674 | M88177 | S52624 | L07334 | S56396 | AY275466 | BT009801 | BC013816 | BC063000
InterPro IPR000276 | IPR002282 PDB 2B0X GPCRDB ptafr_human
GENEID 5724 MIM 173393
PRINTS PR00237 | PR01153 PFAM PF00001

Details:
NAME PLATELET ACTIVATING FACTOR (PAF) RECEPTOR_PLATELET ACTIVATING FACTOR (PAF) RECEPTOR_Homo sapiens
DESCRIPTION Platelet-activating factor receptor (PAF-R).
SPECIES Homo sapiens COMMON NAME Human NCBI Taxonomy 9606
GENE PTAFR | PAFR
SEQUENCE 
MEPHDSSHMDSEFRYTLFPIVYSIIFVLGVIANGYVLWVFARLYPCKKFNEIKIFMVNLT
MADMLFLITLPLWIVYYQNQGNWILPKFLCNVAGCLFFINTYCSVAFLGVITYNRFQAVT
RPIKTAQANTRKRGISLSLVIWVAIVGAASYFLILDSTNTVPDSAGSGNVTRCFEHYEKG
SVPVLIIHIFIVFSFFLVFLIILFCNLVIIRTLLMQPVQQQRNAEVKRRALWMVCTVLAV
FIICFVPHHVVQLPWTLAELGFQDSKFHQAINDAHQVTLCLLSTNCVLDPVIYCFLTKKF
RKHLTEKFYSMRSSRKCSRATTDTVTEVVVPFNQIPGNSLKN
 FRAGMENT NO

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Dimerization:
HOMODIMER INFORMATION There is experimental evidence for homo-dimerization METHOD Immunoprecipitation REFERENCES 7929127

Coupling with G-proteins:
Family:Gi/o REFERENCES:7876256
1GPR0020Galpha-o1-Homo sapiens
2GPR0109Galpha-i3-Homo sapiens
3GPR0218Galpha-i1-Homo sapiens-1
4GPR0226Galpha-i2-Homo sapiens-2
5GPR0261Galpha-i1-Homo sapiens-2
6GPR0334Galpha-o-Homo sapiens
7GPR0365Galpha-i2-Homo sapiens-1
Family:Gq/11 REFERENCES:7876256
8GPR0002Galpha-q-Homo sapiens-2
9GPR0029Galpha-11-Homo sapiens
10GPR0237Galpha-q-Homo sapiens-1

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athina University of Athens
 Faculty of Biology
 Dept. of Cell Biology and Biophysics
Biophysics
& Bioinformatics
Laboratory