gpDB: a database of G-proteins and their interaction with GPCRs
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gpDB::Effector View
Entry 1 of 1 :: EFF0556 ::
FAMILY Phospholipases C
SUBFAMILY Phospholipases C beta
TYPE Phospholipase C beta 4

Cross References:
UniProt Q15147 | Q17R56 | Q5JYS8 | Q5JYT0 | Q5JYT4 | Q9BQW5 | Q9BQW6 | Q9BQW8 EMBL L41349 | AL031652 | AL023805 | AL023805 | AL031652 | BC117458
InterPro IPR000008 | IPR009535 | IPR011992 | IPR015359 | IPR013841 | IPR001192 | IPR000909 | IPR001711
PRODOM PD001202 GENEID 5332 MIM 600810
PRINTS PR00390 PFAM PF00168 | PF06631 | PF09279 | PF00388 | PF00387

Details:
NAME Phospholipase C beta-4-Homo sapiens-1
DESCRIPTION 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-4(EC 3.1.4.11) (Phosphoinositide phospholipase C) (Phospholipase C-beta-4) (PLC-beta-4).
SPECIES Homo sapiens COMMON NAME Human NCBI Taxonomy 9606
GENE PLCB4
SEQUENCE
MAKPYEFNWQKEVPSFLQEGAVFDRYEEESFVFEPNCLFKVDEFGFFLTWRSEGKEGQVL
ECSLINSIRSGAIPKDPKILAALEAVGKSENDLEGRIVCVCSGTDLVNISFTYMVAENPE
VTKQWVEGLRSIIHNFRANNVSPMTCLKKHWMKLAFMTNTNGKIPVRSITRTFASGKTEK
VIFQALKELGLPSGKNDEIEPTAFSYEKFYELTQKICPRTDIEDLFKKINGDKTDYLTVD
QLVSFLNEHQRDPRL
FRAGMENT NO
FUNCTION The production of the second messenger moleculess diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) iss mediated by activated phosphatidylinositol-specific phospholipases C enzymes
Interacting with G-proteins:
Family:Gq/11 REFERENCES:15251227 | 16182515 | 11015615
1GPR0029Galpha-11-Homo sapiens
2GPR0040Galpha-14-Homo sapiens
3GPR0043Galpha-16-Homo sapiens
4GPR0002Galpha-q-Homo sapiens-2
5GPR0237Galpha-q-Homo sapiens-1


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athina University of Athens
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