gpDB: a database of G-proteins and their interaction with GPCRs
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gpDB::Effector View
Entry 1 of 1 :: EFF0434 ::
FAMILY Guanine nucleotide exchange factors
SUBFAMILY RhoGEFs
TYPE LARG RhoGEF

Cross References:
UniProt Q9NZN5 | O15086 EMBL AF180681 | AB002380
InterPro IPR000219 | IPR001331 | IPR001478 | IPR001849 | IPR011993 | IPR015212 | IPR015721 PDB 1TXD | 1X86
GENEID 23365 MIM 604763
PFAM PF00595 | PF09128 | PF00621

Details:
NAME LARG RhoGEF-Homo sapiens-1
DESCRIPTION Rho guanine nucleotide exchange factor 12 (Leukemia-associatedRhoGEF).
SPECIES Homo sapiens COMMON NAME Human NCBI Taxonomy 9606
GENE ARHGEF12 | KIAA0382 | LARG
SEQUENCE 
MSGTQSTITDRFPLKKPIRHGSILNRESPTDKKQKVERIASHDFDPTDSSSKKTKSSSEE
SRSEIYGLVQRCVIIQKDDNGFGLTVSGDNPVFVQSVKEDGAAMRAGVQTGDRIIKVNGT
LVTHSNHLEVVKLIKSGSYVALTVQGRPPGSPQIPLADSEVEPSVIGHMSPIMTSPHSPG
ASGNMERITSPVLMGEENNVVHNQKVEILRKMLQKEQERLQLLQEDYNRTPAQRLLKEIQ
EAKKHIPQLQEQLSK
 FRAGMENT NO
FUNCTION May play a role in the regulation of RhoA GTPase bys guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13)
Interacting with G-proteins:
Family:G12/13 REFERENCES:15251227 | 12024019 | 14607242
1GPR0034Galpha-12-Homo sapiens
2GPR0037Galpha-13-Homo sapiens
Family:Gq/11 REFERENCES:15251227 | 12024019
3GPR0002Galpha-q-Homo sapiens-2
4GPR0237Galpha-q-Homo sapiens-1

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