gpDB: a database of G-proteins and their interaction with GPCRs
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gpDB::Effector View
Entry 1 of 1 :: EFF0517 ::
FAMILY Phospholipases C
SUBFAMILY Phospholipases C beta
TYPE Phospholipase C beta 1

Cross References:
UniProt Q9NQ66 | O60325 | Q5TFF7 | Q5TGC9 | Q8IV93 | Q9BQW2 | Q9H4H2 | Q9H8H5 EMBL AJ278313 | AJ278314 | AY004175 | AB011153 | AL031683 | AL034551 | AL049593 | AL049632 | AL050315 | AL050323 | AL031683 | AL034551 | AL050315 | AL049632 | AL050323 | AL034551 | AL031683 | AL049593 | AL049632 | AL050315 | AL050323 | AL034551 | AL031683 | AL050315 | AL049632 | AL050323 | AL049593 | AL031683 | AL0
InterPro IPR000008 | IPR011992 | IPR015359 | IPR013841 | IPR001192 | IPR000909 | IPR001711 | IPR014815
PRODOM PD001202 GENEID 23236 MIM 607120
PRINTS PR00390 PFAM PF00168 | PF09279 | PF00388 | PF00387 | PF08703

Details:
NAME Phospholipase C beta-1-Homo sapiens-1
DESCRIPTION 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-1(EC 3.1.4.11) (Phosphoinositide phospholipase C) (Phospholipase C-beta-1) (PLC-beta-1) (PLC-I) (PLC-154).
SPECIES Homo sapiens COMMON NAME Human NCBI Taxonomy 9606
GENE PLCB1 | KIAA0581
SEQUENCE 
MAGAQPGVHALQLKPVCVSDSLKKGTKFVKWDDDSTIVTPIILRTDPQGFFFYWTDQNKE
TELLDLSLVKDARCGRHAKAPKDPKLRELLDVGNIGRLEQRMITVVYGPDLVNISHLNLV
AFQEEVAKEWTNEVFSLATNLLAQNMSRDAFLEKAYTKLKLQVTPEGRIPLKNIYRLFSA
DRKRVETALEACSLPSSRNDSIPQEDFTPEVYRVFLNNLCPRPEIDNIFSEFGAKSKPYL
TVDQMMDFINLKQRD
 FRAGMENT NO
FUNCTION The production of the second messenger moleculess diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) iss mediated by activated phosphatidylinositol-specific phospholipases C enzymes
Interacting with G-proteins:
Family:Gq/11 REFERENCES:15251227 | 16182515 | 11015615
1GPR0029Galpha-11-Homo sapiens
2GPR0040Galpha-14-Homo sapiens
3GPR0043Galpha-16-Homo sapiens
4GPR0002Galpha-q-Homo sapiens-2
5GPR0237Galpha-q-Homo sapiens-1
Family:Gbeta REFERENCES:15251227 | 11015615 | 8383116
6GPR0147Gbeta-1-Homo sapiens
7GPR0155Gbeta-2-Homo sapiens
8GPR0160Gbeta-3-Homo sapiens-1
9GPR0164Gbeta-4-Homo sapiens
10GPR0167Gbeta-5-Homo sapiens-2
11GPR0363Gbeta-3-Homo sapiens-2
12GPR0366Gbeta-5-Homo sapiens-1
13GPR0402unclassified_Gbeta-Homo sapiens
Family:Ggamma REFERENCES:15251227 | 11015615 | 8383116
14GPR0176Ggamma-t1-Homo sapiens
15GPR0179Ggamma-2-Homo sapiens
16GPR0183Ggamma-3-Homo sapiens
17GPR0185Ggamma-4-Homo sapiens
18GPR0188Ggamma-5-Homo sapiens-2
19GPR0192Ggamma-7-Homo sapiens
20GPR0195Ggamma-8-Homo sapiens-2
21GPR0198Ggamma-10-Homo sapiens-2
22GPR0199Ggamma-11-Homo sapiens
23GPR0203Ggamma-12-Homo sapiens
24GPR0205Ggamma-13-Homo sapiens
25GPR0210Ggamma-8-Homo sapiens-1
26GPR0253Ggamma-5-Homo sapiens-1
27GPR0364Ggamma-10-Homo sapiens-1

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athina University of Athens
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