gpDB: a database of G-proteins and their interaction with GPCRs
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gpDB::GPCR View
Entry 1 of 1 :: GPCR0745 ::
CLASS CLASS A (RHODOPSIN LIKE)
FAMILY CHOLECYSTOKININ AND GASTRIN RECEPTOR
SUBFAMILY CCK2

Cross References:
UniProt P32239 EMBL L08112 | L04473 | L10822 | D13305 | L07746 | AY322551 | BT006789
InterPro IPR009126 | IPR000314 | IPR000276 PDB 1L4T GPCRDB gasr_human
GENEID 887 MIM 118445
PRINTS PR01822 | PR00527 | PR00237 PFAM PF00001

Details:
NAME CHOLECYSTOKININ AND GASTRIN RECEPTOR_CCK2_Homo sapiens
DESCRIPTION Gastrin/cholecystokinin type B receptor (CCK-B receptor) (CCK-BR)(Cholecystokinin-2 receptor) (CCK2-R).
SPECIES Homo sapiens COMMON NAME Human NCBI Taxonomy 9606
GENE CCKBR | CCKRB
SEQUENCE
MELLKLNRSVQGTGPGPGASLCRPGAPLLNSSSVGNLSCEPPRIRGAGTRELELAIRITL
YAVIFLMSVGGNMLIIVVLGLSRRLRTVTNAFLLSLAVSDLLLAVACMPFTLLPNLMGTF
IFGTVICKAVSYLMGVSVSVSTLSLVAIALERYSAICRPLQARVWQTRSHAARVIVATWL
LSGLLMVPYPVYTVVQPVGPRVLQCVHRWPSARVRQTWSVLLLLLLFFIPGVVMAVAYGL
ISRELYLGLRFDGDSDSDSQSRVRNQGGLPGAVHQNGRCRPETGAVGEDSDGCYVQLPRS
RPALELTALTAPGPGSGSRPTQAKLLAKKRVVRMLLVIVVLFFLCWLPVYSANTWRAFDG
PGAHRALSGAPISFIHLLSYASACVNPLVYCFMHRRFRQACLETCARCCPRPPRARPRAL
PDEDPPTPSIASLSRLSYTTISTLGPG
FRAGMENT NO

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Dimerization:
HOMODIMER INFORMATION There is experimental evidence for homo-dimerization METHOD Bioluminescence Resonance Energy Transfer (BRET) REFERENCES 11673456
HOMODIMER INFORMATION There is experimental evidence for homo-dimerization METHOD Bioluminescence Resonance Energy Transfer (BRET) REFERENCES 11673456

Coupling with G-proteins:
Family:Gq/11 REFERENCES:1280419
1GPR0002Galpha-q-Homo sapiens-2
2GPR0029Galpha-11-Homo sapiens
3GPR0237Galpha-q-Homo sapiens-1


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athina University of Athens
Faculty of Biology
Dept. of Cell Biology and Biophysics
Biophysics
& Bioinformatics
Laboratory