gpDB: a database of G-proteins and their interaction with GPCRs
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gpDB::GPCR View
Entry 1 of 1 :: GPCR2377 ::
CLASS CLASS A (RHODOPSIN LIKE)
FAMILY P2Y RECEPTOR
SUBFAMILY P2Y1

Cross References:
UniProt P47900 EMBL Z49205 | U42030 | U42029 | S81950 | AJ006945 | AY136752 | BC074784 | BC074785 | AF018284
InterPro IPR000276 | IPR002286 | IPR000142 PDB 1Y36 GPCRDB p2ry1_human
GENEID 5028 MIM 601167
PRINTS PR00237 | PR00595 | PR01157 PFAM PF00001

Details:
NAME P2Y RECEPTOR_P2Y1_Homo sapiens-2
DESCRIPTION P2Y purinoceptor 1 (ATP receptor) (P2Y1) (Purinergic receptor).
SPECIES Homo sapiens COMMON NAME Human NCBI Taxonomy 9606
GENE P2RY1
SEQUENCE
MTEVLWPAVPNGTDAAFLAGPGSSWGNSTVASTAAVSSSFKCALTKTGFQFYYLPAVYIL
VFIIGFLGNSVAIWMFVFHMKPWSGISVYMFNLALADFLYVLTLPALIFYYFNKTDWIFG
DAMCKLQRFIFHVNLYGSILFLTCISAHRYSGVVYPLKSLGRLKKKNAICISVLVWLIVV
VAISPILFYSGTGVRKNKTITCYDTTSDEYLRSYFIYSMCTTVAMFCVPLVLILGCYGLI
VRALIYKDLDNSPLRRKSIYLVIIVLTVFAVSYIPFHVMKTMNLRARLDFQTPAMCAFND
RVYATYQVTRGLASLNSCVDPILYFLAGDTFRRRLSRATRKASRRSEANLQSKSEDMTLN
ILPEFKQNGDTSL
FRAGMENT NO

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Dimerization:
HETERODIMER INFORMATION Forms heterodimers with Adenosine A1 Receptor. Heterodimerization results in altered ligand binding METHOD Immunoprecipitation, Bioluminescence Resonance Energy Transfer (BRET) REFERENCES 11390975 | 12417330 | 12123822

Scaffold:
TYPE NHERF1( Na+/H+ exchange regulatory factor) /EBP50( ezrin-radixin-moesin binding phosphoprotein 50-kD protein) REFERENCES 9671706

Coupling with G-proteins:
Family:Gq/11 REFERENCES:8159738
1GPR0002Galpha-q-Homo sapiens-2
2GPR0029Galpha-11-Homo sapiens
3GPR0237Galpha-q-Homo sapiens-1


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