gpDB: a database of G-proteins and their interaction with GPCRs
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gpDB::Effector View
Entry 1 of 1 :: EFF0442 ::
FAMILY Guanine nucleotide exchange factors
SUBFAMILY RhoGEFs
TYPE Lbc RhoGEF

Cross References:
UniProt Q12802 | Q14572 | Q59FP6 | Q86W90 | Q8WXQ6 | Q96JP6 | Q96P79 | Q9Y5T0 EMBL U03634 | AF126008 | AF127481 | AF387101 | AF406992 | AB055890 | BC050312 | M90360 | AB209414
InterPro IPR002219 | IPR000219 | IPR001331 | IPR001849 | IPR011993 | IPR015721 PDB 2DRN
GENEID 11214 MIM 604686
PFAM PF00130 | PF00169 | PF00621

Details:
NAME Lbc RhoGEF-Homo sapiens
DESCRIPTION A-kinase anchor protein 13 (AKAP 13) (Protein kinase A-anchoringprotein 13) (Breast cancer nuclear receptor-binding auxiliary protein)(Human thyroid-anchoring protein 31) (Guanine nucleotide exchangefactor Lbc) (AKAP-Lbc) (LBC oncogene) (P47) (Lymphoid bl
SPECIES Homo sapiens COMMON NAME Human NCBI Taxonomy 9606
GENE AKAP13 | BRX | HT31 | LBC
SEQUENCE
MKLNPQQAPLYGDCVVTVLLAEEDKAEDDVVFYLVFLGSTLRHCTSTRKVSSDTLETIAP
GHDCCETVKVQLCASKEGLPVFVVAEEDFHFVQDEAYDAAQFLATSAGNQQALNFTRFLD
QSGPPSGDVNSLDKKLVLAFRHLKLPTEWNVLGTDQSLHDAGPRETLMHFAVRLGLLRLT
WFLLQKPGGRGALSIHNQEGATPVSLALERGYHKLHQLLTEENAGEPDSWSSLSYEIPYG
DCSVRHHRELDIYTL
FRAGMENT NO
FUNCTION Anchors cAMP-dependent protein kinase (PKA) and acts ass an adapter protein to selectively couple G alpha-13 and Rho
Interacting with G-proteins:
Family:Gq/11 REFERENCES:16182515
1GPR0002Galpha-q-Homo sapiens-2
2GPR0237Galpha-q-Homo sapiens-1


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