gpDB: a database of G-proteins and their interaction with GPCRs
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gpDB::GPCR View
Entry 1 of 1 :: GPCR0910 ::
CLASS CLASS A (RHODOPSIN LIKE)
FAMILY GONADOTROPIN-RELEASING HORMONE RECEPTOR
SUBFAMILY GNRH2

Cross References:
UniProt Q96P88 | Q8TCX8 EMBL AF403014 | AY081843
InterPro IPR000276 | IPR001658 GPCRDB gnrr2_human
PRINTS PR00529 | PR00237 PFAM PF00001

Details:
NAME GONADOTROPIN-RELEASING HORMONE RECEPTOR_GNRH2_Homo sapiens
DESCRIPTION Putative gonadotropin-releasing hormone II receptor (Type II GnRHreceptor) (GnRH-II-R).
SPECIES Homo sapiens COMMON NAME Human NCBI Taxonomy 9606
GENE GNRHR2
SEQUENCE
MSAGNGTPWGSAAGEEVWAGSGVEVEGSELPTFSAAAKVRVGVTIVLFVSSAGGNLAVLW
SVTRREPSQLRPSPVRRLFIHLAAADLLVTFVVMPLDATWNITVQWLAVDIACRTLMFLK
LMATYSAAFLPVVIGLDRQAAVLNPLGSRSGVRKLLGAAWGLSFLLAFPQLFLFHTVHXA
GPVPFTQCVTKGSFKAQWQETTYNLFTFCCLFLLPLTAMAICYSRIVLSVSRPQTRKGSH
APAGEFALPRSFDNCPRVRLRALRLALLILLTFILCWTPYYLLGMWYWFSPTMLTEVPPS
LSHILFLLGLLNAPLDPLLYGAFTLGCRRGHQELSIDSSKEGSGRMLQEEIHAFRQLEVQ
KTVTSRRAGETKGISITSI
FRAGMENT NO

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Dimerization:
HOMODIMER INFORMATION There is experimental evidence for homo-dimerization METHOD Bioluminescence Resonance Energy Transfer (BRET) REFERENCES 11278883
HOMODIMER INFORMATION There is experimental evidence for homo-dimerization METHOD Photobleaching Fluorescence Resonance Energy Transfer (FRET) REFERENCES 11035030 | 11328852

Coupling with G-proteins:
Family:Gq/11 REFERENCES:1333190
1GPR0002Galpha-q-Homo sapiens-2
2GPR0029Galpha-11-Homo sapiens
3GPR0237Galpha-q-Homo sapiens-1


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athina University of Athens
Faculty of Biology
Dept. of Cell Biology and Biophysics
Biophysics
& Bioinformatics
Laboratory