| Details: |
| NAME |
THYROTROPIN-RELEASING HORMONE RECEPTOR_TRH1_Homo sapiens |
| DESCRIPTION |
Thyrotropin-releasing hormone receptor (TRH-R) (Thyroliberinreceptor). |
| SPECIES |
Homo sapiens |
COMMON NAME |
Human |
NCBI Taxonomy |
9606 |
| GENE |
TRHR |
| SEQUENCE |
MENETVSELNQTQLQPRAVVALEYQVVTILLVLIICGLGIVGNIMVVLVVMRTKHMRTPT
NCYLVSLAVADLMVLVAAGLPNITDSIYGSWVYGYVGCLCITYLQYLGINASSCSITAFT
IERYIAICHPIKAQFLCTFSRAKKIIIFVWAFTSLYCMLWFFLLDLNISTYKDAIVISCG
YKISRNYYSPIYLMDFGVFYVVPMILATVLYGFIARILFLNPIPSDPKENSKTWKNDSTH
QNTNLNVNTSNRCFNSTVSSRKQVTKMLAVVVILFALLWMPYRTLVVVNSFLSSPFQENW
FLLFCRICIYLNSAINPVIYNLMSQKFRAAFRKLCNCKQKPTEKPANYSVALNYSVIKES
DHFSTELDDITVTDTYLSATKVSFDDTCLASEVSFSQS
|
FRAGMENT |
NO
|
|
|
|
|
Homepage
|
| Dimerization: |
| HOMODIMER INFORMATION |
There is experimental evidence for homo-dimerization
|
METHOD |
Bioluminescence Resonance Energy Transfer (BRET)
|
REFERENCES |
12393857 | 11278883
|
| HOMODIMER INFORMATION |
There is experimental evidence for homo-dimerization
|
METHOD |
Immunoprecipitation
|
REFERENCES |
12023974
|
| HETERODIMER INFORMATION |
Forms heterodimers with TRH2 Receptors. Dimerization results in altered traffcking and beta-arrestin interactions
|
METHOD |
Bioluminescence Resonance Energy Transfer (BRET)
|
REFERENCES |
12393857
|
| Coupling with G-proteins: |
| Family:Gq/11 |
REFERENCES: | 2175902 | | 1 | GPR0002 | Galpha-q-Homo sapiens-2 | | 2 | GPR0029 | Galpha-11-Homo sapiens | | 3 | GPR0237 | Galpha-q-Homo sapiens-1 |
|
biol.uoa.gr
for comments, corrections and
data (sequence) submission.
