gpDB: a database of G-proteins and their interaction with GPCRs
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gpDB::GPCR View
Entry 1 of 1 :: GPCR0084 ::
CLASS CLASS A (RHODOPSIN LIKE)
FAMILY 5-HYDROXYTRYPTAMINE RECEPTOR
SUBFAMILY 5-HT-2C

Cross References:
UniProt P28335 | Q5VUF8 | Q9NP28 EMBL M81778 | X80763 | U49516 | AF208053 | AF498983 | AC004822 | AL355812 | AL590097 | AC004822 | AL590097 | AC004822 | AL355812 | BC095543
InterPro IPR000377 | IPR002231 | IPR000276 GPCRDB 5ht2c_human
GENEID 3358 MIM 312861
PRINTS PR00517 | PR01101 | PR00237 PFAM PF00001

Details:
NAME 5-HYDROXYTRYPTAMINE RECEPTOR_5-HT-2C_Homo sapiens
DESCRIPTION 5-hydroxytryptamine receptor 2C (5-HT-2C) (Serotonin receptor 2C) (5-HT2C) (5-HTR2C) (5HT-1C).
SPECIES Homo sapiens COMMON NAME Human NCBI Taxonomy 9606
GENE HTR2C | HTR1C
SEQUENCE 
MVNLRNAVHSFLVHLIGLLVWQCDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSI
VIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVW
PLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWA
ISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYV
LRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTM
QAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVC
SGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTN
EPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV
 FRAGMENT NO

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Scaffold:
TYPE MUPP1( multiple activated protein kinase 1) REFERENCES 11150294
TYPE PSD95( postsynaptic density protein) REFERENCES 12006486
TYPE Veli3( vertebrate homologue pf C.elegans Lin-7) REFERENCES 12682061

Coupling with G-proteins:
Family:G12/13 REFERENCES:14722258 | 11572865
1GPR0034Galpha-12-Homo sapiens
2GPR0037Galpha-13-Homo sapiens
Family:Gq/11 REFERENCES:1302605
3GPR0002Galpha-q-Homo sapiens-2
4GPR0029Galpha-11-Homo sapiens
5GPR0237Galpha-q-Homo sapiens-1

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athina University of Athens
 Faculty of Biology
 Dept. of Cell Biology and Biophysics
Biophysics
& Bioinformatics
Laboratory