gpDB: a database of G-proteins and their interaction with GPCRs
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gpDB::Effector View
Entry 1 of 1 :: EFF0586 ::
FAMILY PI3/PI4 kinases
SUBFAMILY Class Ib PI3Ks
TYPE PI3K gamma

Cross References:
UniProt P48736 | Q8IV23 | Q9BZC8 EMBL X83368 | AF327656 | AC005018 | BC035683
InterPro IPR000403 | IPR002420 | IPR000341 | IPR001263 | IPR015433 PDB 1E8Y | 1E8Z | 1HE8 | 2A4Z | 2A5U | 2CHW | 2CHX | 2CHZ
GENEID 5294 MIM 601232
PFAM PF00454 | PF00792 | PF00794 | PF00613

Details:
NAME PI3K gamma-Homo sapiens
DESCRIPTION Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gammaisoform (EC 2.7.1.153) (PI3-kinase p110 subunit gamma) (PtdIns-3-kinase subunit p110) (PI3K) (PI3Kgamma) (p120-PI3K).
SPECIES Homo sapiens COMMON NAME Human NCBI Taxonomy 9606
GENE PIK3CG
SEQUENCE 
MELENYKQPVVLREDNCRRRRRMKPRSAAASLSSMELIPIEFVLPTSQRKCKSPETALLH
VAGHGNVEQMKAQVWLRALETSVAADFYHRLGPHHFLLLYQKKGQWYEIYDKYQVVQTLD
CLRYWKATHRSPGQIHLVQRHPPSEESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGL
VTPRMAEVASRDPKLYAMHPWVTSKPLPEYLWKKIANNCIFIVIHRSTTSQTIKVSPDDT
PGAILQSFFTKMAKK
 FRAGMENT NO
FUNCTION 3-phosphorylates the cellular phosphoinositide PtdIns-s 4,5-biphosphate (PtdIns(4,5)P2) to produce PtdIns-3, 4,5-s triiphosphate (PtdIns(3,4,5)P3)
Interacting with G-proteins:
Family:Gq/11 REFERENCES:16182515
1GPR0002Galpha-q-Homo sapiens-2
2GPR0237Galpha-q-Homo sapiens-1
Family:Gbeta REFERENCES:12502714
3GPR0147Gbeta-1-Homo sapiens
4GPR0155Gbeta-2-Homo sapiens
5GPR0160Gbeta-3-Homo sapiens-1
6GPR0164Gbeta-4-Homo sapiens
7GPR0167Gbeta-5-Homo sapiens-2
8GPR0363Gbeta-3-Homo sapiens-2
9GPR0366Gbeta-5-Homo sapiens-1
10GPR0402unclassified_Gbeta-Homo sapiens
Family:Ggamma REFERENCES:12502714
11GPR0176Ggamma-t1-Homo sapiens
12GPR0179Ggamma-2-Homo sapiens
13GPR0183Ggamma-3-Homo sapiens
14GPR0185Ggamma-4-Homo sapiens
15GPR0188Ggamma-5-Homo sapiens-2
16GPR0192Ggamma-7-Homo sapiens
17GPR0195Ggamma-8-Homo sapiens-2
18GPR0198Ggamma-10-Homo sapiens-2
19GPR0199Ggamma-11-Homo sapiens
20GPR0203Ggamma-12-Homo sapiens
21GPR0205Ggamma-13-Homo sapiens
22GPR0210Ggamma-8-Homo sapiens-1
23GPR0253Ggamma-5-Homo sapiens-1
24GPR0364Ggamma-10-Homo sapiens-1

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