gpDB: a database of G-proteins and their interaction with GPCRs
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gpDB::GPCR View
Entry 1 of 1 :: GPCR0871 ::
CLASS CLASS A (RHODOPSIN LIKE)
FAMILY GLYCOPROTEIN HORMONE RECEPTOR
SUBFAMILY LSH RECEPTOR

Cross References:
UniProt P22888 | Q14751 | Q15996 | Q9UEW9 EMBL M73746 | S57793 | M63108 | X84753 | X84754 | X84755 | X84756 | X84757 | X84758 | X84759 | X84760 | X84761 | X84762 | X84763 | AF082076 | AF024642
InterPro IPR000276 | IPR002131 | IPR000372 | IPR002273 PDB 1LUT | 1XUL GPCRDB lshr_human
GENEID 3973 MIM 152790 | 176410
PRINTS PR00373 | PR00237 | PR01144 PFAM PF00001

Details:
NAME GLYCOPROTEIN HORMONE RECEPTOR_LSH RECEPTOR_Homo sapiens
DESCRIPTION Lutropin-choriogonadotropic hormone receptor precursor (LH/CG-R) (LSH-R) (Luteinizing hormone receptor) (LHR).
SPECIES Homo sapiens COMMON NAME Human NCBI Taxonomy 9606
GENE LHCGR | LCGR | LGR2 | LHRHR
SEQUENCE
MKQRFSALQLLKLLLLLQPPLPRALREALCPEPCNCVPDGALRCPGPTAGLTRLSLAYLP
VKVIPSQAFRGLNEVIKIEISQIDSLERIEANAFDNLLNLSEILIQNTKNLRYIEPGAFI
NLPRLKYLSICNTGIRKFPDVTKVFSSESNFILEICDNLHITTIPGNAFQGMNNESVTLK
LYGNGFEEVQSHAFNGTTLTSLELKENVHLEKMHNGAFRGATGPKTLDISSTKLQALPSY
GLESIQRLIATSSYSLKKLPSRETFVNLLEATLTYPSHCCAFRNLPTKEQNFSHSISENF
SKQCESTVRKVSNKTLYSSMLAESELSGWDYEYGFCLPKTPRCAPEPDAFNPCEDIMGYD
FLRVLIWLINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYLLLIASVDS
QTKGQYYNHAIDWQTGSGCSTAGFFTVFASELSVYTLTVITLERWHTITYAIHLDQKLRL
RHAILIMLGGWLFSSLIAMLPLVGVSNYMKVSICFPMDVETTLSQVYILTILILNVVAFF
IICACYIKIYFAVRNPELMATNKDTKIAKKMAILIFTDFTCMAPISFFAISAAFKVPLIT
VTNSKVLLVLFYPINSCANPFLYAIFTKTFQRDFFLLLSKFGCCKRRAELYRRKDFSAYT
SNCKNGFTGSNKPSQSTLKLSTLHCQGTALLDKTRYTEC
FRAGMENT NO

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Dimerization:
HOMODIMER INFORMATION There is experimental evidence for homo-dimerization METHOD Photobleaching Fluorescence Resonance Energy Transfer (FRET) REFERENCES 11108263

Scaffold:
TYPE GIPC( GAIP-interacting protein) REFERENCES 14507927
TYPE NHERF1( Na+/H+ exchange regulatory factor) /EBP50( ezrin-radixin-moesin binding phosphoprotein 50-kD protein) REFERENCES 14507927
TYPE p38JAB1 REFERENCES 10788448

Coupling with G-proteins:
Family:Gi/o REFERENCES:1516719
1GPR0020Galpha-o1-Homo sapiens
2GPR0109Galpha-i3-Homo sapiens
3GPR0218Galpha-i1-Homo sapiens-1
4GPR0226Galpha-i2-Homo sapiens-2
5GPR0261Galpha-i1-Homo sapiens-2
6GPR0334Galpha-o-Homo sapiens
7GPR0365Galpha-i2-Homo sapiens-1
Family:Gq/11 REFERENCES:1516719
8GPR0002Galpha-q-Homo sapiens-2
9GPR0029Galpha-11-Homo sapiens
10GPR0237Galpha-q-Homo sapiens-1
Family:Gs REFERENCES:1516719
11GPR0119Galpha-s-Homo sapiens-2
12GPR0263Galpha-s-Homo sapiens-4
13GPR0266Galpha-s-Homo sapiens-5
14GPR0267Galpha-s-Homo sapiens-6
15GPR0277Galpha-s-Homo sapiens-7
16GPR0278Galpha-s-Homo sapiens
17GPR0395Galpha-s-Homo sapiens-3


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athina University of Athens
Faculty of Biology
Dept. of Cell Biology and Biophysics
Biophysics
& Bioinformatics
Laboratory