gpDB: a database of G-proteins and their interaction with GPCRs
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gpDB::GPCR View
Entry 1 of 1 :: GPCR0200 ::
CLASS CLASS A (RHODOPSIN LIKE)
FAMILY ADRENOCEPTOR (A1-ADRENOCEPTOR)
SUBFAMILY A1A(Adrenoceptor)

Cross References:
UniProt Q9UD67
InterPro IPR001004 | IPR002233 | IPR000276 GPCRDB q9ud67_human
PRINTS PR01103 | PR00557 | PR00237 PFAM PF00001

Details:
NAME ADRENOCEPTOR (A1-ADRENOCEPTOR)_A1A(Adrenoceptor)_Homo sapiens-6
DESCRIPTION Alpha 1C-adrenoceptor, alpha 1C-AR .
SPECIES Homo sapiens COMMON NAME Human NCBI Taxonomy 9606
GENE -
SEQUENCE
ACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCT
ASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPLFGWRQPAPE
DETICQINEEPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQ
VTLRIHRKNAPAGGSGMASAKTKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLV
MPIGSFFPDFKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQCLRRKQS
SKHALGYTLHPPSQAVEGQHKDMVRIPVGSRETFYRISKTDGVCEWKFF
FRAGMENT YES

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Dimerization:
HOMODIMER INFORMATION There is experimental evidence for homo-dimerization METHOD Immunoprecipitation, Fluorescence Resonance Energy Transfer (FRET) REFERENCES 12888550
HETERODIMER INFORMATION Forms heterodimers with A1B Adrenoceptors. Heterodimerization results in altered internalization of the receptor METHOD Fluorescence Resonance Energy Transfer (FRET) REFERENCES 12888550

Scaffold:
TYPE nNOS( neuronal nitric oxide synthase) NOS1 REFERENCES 12184796

Coupling with G-proteins:
Family:G12/13 REFERENCES:12433842
1GPR0034Galpha-12-Homo sapiens
2GPR0037Galpha-13-Homo sapiens
Family:Gq/11 REFERENCES:8396931
3GPR0002Galpha-q-Homo sapiens-2
4GPR0029Galpha-11-Homo sapiens
5GPR0237Galpha-q-Homo sapiens-1


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athina University of Athens
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Dept. of Cell Biology and Biophysics
Biophysics
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Laboratory