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gpDB::G-protein View
Entry 1 of 1 :: GPR0227 ::
CLASS Galpha
FAMILY Gi/o
SUBFAMILY Galpha-i
TYPE Galpha-i2

Cross References:
UniProt P08752 | Q6P1C0 EMBL M13963 | BC065159 | S71213
InterPro IPR001019 | IPR001408 | IPR011025
PRODOM PD000281
PRINTS PR00318 | PR00441 PFAM PF00503

Details:
NAME Galpha-i2-Mus musculus-2
DESCRIPTION Guanine nucleotide-binding protein G(i), alpha-2 subunit (Adenylatecyclase-inhibiting G alpha protein).
SPECIES Mus musculus COMMON NAME Mouse NCBI Taxonomy 10090
POST TRANSLATION MODIFICATIONS null GENE Gnai2 | Gnai-2
SEQUENCE 
MGCTVSAEDKAAAERSKMIDKNLREDGEKAAREVKLLLLGAGESGKSTIVKQMKIIHEDG
YSEEECRQYRAVVYSNTIQSILAIVKAMGNLQIDFADPQRADDARQLFALSCAAEEQGML
PEDLSGVIRRLWADHGVQACFGRSREYQLNDSAAYYLNDLERIAQSDYIPTQQDVLRTRV
KTTGIVETHFTFKDLHFKMFDVGGQRSERKKWIHCFEGVTAIIFCVALSAYDLVLAEDEE
MNRMHESMKLFDSICNNKWFTDTSIILFLNKKDLFEEKITQSSLTICFPEYTGANKYDEA
ASYIQSKFEDLNKRKDTKEIYTHFTCATDTKNVQFVFDAVTDVIIKNNLKDCGLF
 FRAGMENT NO
FUNCTION Guanine nucleotide-binding proteins (G proteins) ares involved as modulators or transducers in various transmembranes signaling systems
Effectors:
1EFF0004Adenylate cyclase-1-Mus musculus-1Inhibition15251227 | 15922020 | 14993377 | 11376933
2EFF0005Adenylate cyclase-1-Mus musculus-2Inhibition15251227 | 15922020 | 14993377 | 11376933
3EFF0032Adenylate cyclase-5-Mus musculus-1Inhibition15251227 | 15922020 | 14993377 | 11376933
4EFF0033Adenylate cyclase-5-Mus musculus-2Inhibition15251227 | 15922020 | 14993377 | 11376933
5EFF0040Adenylate cyclase-6-Mus musculus-1Inhibition15251227 | 15922020 | 14993377 | 11376933
6EFF0041Adenylate cyclase-6-Mus musculus-2Inhibition15251227 | 15922020 | 14993377 | 11376933
7EFF0343G-protein-regulated inducer of neurite outgrowth GRIN1-Mus musculusUnknown15251227 | 10480904 | 14671004
8EFF0399Kir 3.1(GIRK1)-Mus musculus-1Stimulation15251227 | 14963032 | 11779482
9EFF0400Kir 3.1(GIRK1)-Mus musculus-2Stimulation15251227 | 14963032 | 11779482
10EFF0401Kir 3.1(GIRK1)-Mus musculus-3Stimulation15251227 | 14963032 | 11779482
11EFF0402Kir 3.1(GIRK1)-Mus musculus-4Stimulation15251227 | 14963032 | 11779482
12EFF0412Kir 3.2(GIRK2)-Mus musculus-1Stimulation15251227 | 14963032 | 11779482
13EFF0413Kir 3.2(GIRK2)-Mus musculus-2Stimulation15251227 | 14963032 | 11779482
14EFF0414Kir 3.2(GIRK2)-Mus musculus-3Stimulation15251227 | 14963032 | 11779482
15EFF0415Kir 3.2(GIRK2)-Mus musculus-4Stimulation15251227 | 14963032 | 11779482
16EFF0421Kir 3.3(GIRK3)-Mus musculus-1Stimulation15251227 | 14963032 | 11779482
17EFF0422Kir 3.3(GIRK3)-Mus musculus-2Stimulation15251227 | 14963032 | 11779482
18EFF0427Kir 3.4(GIRK4)-Mus musculus-1Stimulation15251227 | 14963032 | 11779482
19EFF0428Kir 3.4(GIRK4)-Mus musculus-2Stimulation15251227 | 14963032 | 11779482
20EFF0429Kir 3.4(GIRK4)-Mus musculus-3Stimulation15251227 | 14963032 | 11779482
21EFF0430Kir 3.4(GIRK4)-Mus musculus-4Stimulation15251227 | 14963032 | 11779482
22EFF0647Rac-Mus musculus-1Stimulation11099498
23EFF0648Rac-Mus musculus-5Stimulation11099498
24EFF0649Rac-Mus musculus-2Stimulation11099498
25EFF0650Rac-Mus musculus-3Stimulation11099498
26EFF0651Rac-Mus musculus-4Stimulation11099498
27EFF0653Rac-Mus musculus-6Stimulation11099498
28EFF0654Rac-Mus musculus-7Stimulation11099498
29EFF0655Rac-Mus musculus-8Stimulation11099498
30EFF0656Rac-Mus musculus-9Stimulation11099498
31EFF0859Src tyrosine kinase-Mus musculus-1Stimulation11007482 | 15251227 | 12209124
32EFF0860Src tyrosine kinase-Mus musculus-2Stimulation11007482 | 15251227 | 12209124
33EFF0861Src tyrosine kinase-Mus musculus-3Stimulation11007482 | 15251227 | 12209124
34EFF0862Src tyrosine kinase-Mus musculus-4Stimulation11007482 | 15251227 | 12209124
35EFF0863Src tyrosine kinase-Mus musculus-5Stimulation11007482 | 15251227 | 12209124
36EFF0864Src tyrosine kinase-Mus musculus-6Stimulation11007482 | 15251227 | 12209124
37EFF0865Src tyrosine kinase-Mus musculus-7Stimulation11007482 | 15251227 | 12209124
38EFF0866Src tyrosine kinase-Mus musculus-8Stimulation11007482 | 15251227 | 12209124
39EFF1192Tubulin-Mus musculus-1Stimulation of GTPase activity10224115 | 15251227 | 16380086
40EFF1193Tubulin-Mus musculus-10Stimulation of GTPase activity10224115 | 15251227 | 16380086
41EFF1194Tubulin-Mus musculus-11Stimulation of GTPase activity10224115 | 15251227 | 16380086
42EFF1195Tubulin-Mus musculus-12Stimulation of GTPase activity10224115 | 15251227 | 16380086
43EFF1202Tubulin-Mus musculus-19Stimulation of GTPase activity10224115 | 15251227 | 16380086
44EFF1203Tubulin-Mus musculus-2Stimulation of GTPase activity10224115 | 15251227 | 16380086
45EFF1209Tubulin-Mus musculus-25Stimulation of GTPase activity10224115 | 15251227 | 16380086
46EFF1214Tubulin-Mus musculus-3Stimulation of GTPase activity10224115 | 15251227 | 16380086
47EFF1217Tubulin-Mus musculus-32Stimulation of GTPase activity10224115 | 15251227 | 16380086
48EFF1218Tubulin-Mus musculus-33Stimulation of GTPase activity10224115 | 15251227 | 16380086
49EFF1220Tubulin-Mus musculus-35Stimulation of GTPase activity10224115 | 15251227 | 16380086
50EFF1221Tubulin-Mus musculus-34Stimulation of GTPase activity10224115 | 15251227 | 16380086
51EFF1223Tubulin-Mus musculus-31Stimulation of GTPase activity10224115 | 15251227 | 16380086
52EFF1225Tubulin-Mus musculus-4Stimulation of GTPase activity10224115 | 15251227 | 16380086
53EFF1226Tubulin-Mus musculus-30Stimulation of GTPase activity10224115 | 15251227 | 16380086
54EFF1227Tubulin-Mus musculus-29Stimulation of GTPase activity10224115 | 15251227 | 16380086
55EFF1228Tubulin-Mus musculus-28Stimulation of GTPase activity10224115 | 15251227 | 16380086
56EFF1230Tubulin-Mus musculus-27Stimulation of GTPase activity10224115 | 15251227 | 16380086
57EFF1231Tubulin-Mus musculus-26Stimulation of GTPase activity10224115 | 15251227 | 16380086
58EFF1232Tubulin-Mus musculus-24Stimulation of GTPase activity10224115 | 15251227 | 16380086
59EFF1233Tubulin-Mus musculus-23Stimulation of GTPase activity10224115 | 15251227 | 16380086
60EFF1235Tubulin-Mus musculus-22Stimulation of GTPase activity10224115 | 15251227 | 16380086
61EFF1236Tubulin-Mus musculus-5Stimulation of GTPase activity10224115 | 15251227 | 16380086
62EFF1237Tubulin-Mus musculus-21Stimulation of GTPase activity10224115 | 15251227 | 16380086
63EFF1238Tubulin-Mus musculus-20Stimulation of GTPase activity10224115 | 15251227 | 16380086
64EFF1239Tubulin-Mus musculus-18Stimulation of GTPase activity10224115 | 15251227 | 16380086
65EFF1240Tubulin-Mus musculus-17Stimulation of GTPase activity10224115 | 15251227 | 16380086
66EFF1241Tubulin-Mus musculus-16Stimulation of GTPase activity10224115 | 15251227 | 16380086
67EFF1242Tubulin-Mus musculus-15Stimulation of GTPase activity10224115 | 15251227 | 16380086
68EFF1243Tubulin-Mus musculus-14Stimulation of GTPase activity10224115 | 15251227 | 16380086
69EFF1244Tubulin-Mus musculus-13Stimulation of GTPase activity10224115 | 15251227 | 16380086
70EFF1245Tubulin-Mus musculus-6Stimulation of GTPase activity10224115 | 15251227 | 16380086
71EFF1246Tubulin-Mus musculus-7Stimulation of GTPase activity10224115 | 15251227 | 16380086
72EFF1247Tubulin-Mus musculus-8Stimulation of GTPase activity10224115 | 15251227 | 16380086
73EFF1248Tubulin-Mus musculus-9Stimulation of GTPase activity10224115 | 15251227 | 16380086

Coupling with GPCRs:
1GPCR00165-HYDROXYTRYPTAMINE RECEPTOR_5-HT-1A_Mus musculus3138543
2GPCR00305-HYDROXYTRYPTAMINE RECEPTOR_5-HT-1B_Mus musculus1351684
3GPCR00395-HYDROXYTRYPTAMINE RECEPTOR_5-HT-1D_Mus musculus-21565658
4GPCR00615-HYDROXYTRYPTAMINE RECEPTOR_5-HT-1F_Mus musculus8384716
5GPCR00955-HYDROXYTRYPTAMINE RECEPTOR_5-HT-5A_Mus musculus7988681
6GPCR0171ADENOSINE RECEPTOR_A1_Mus musculus-11662665
7GPCR0177ADENOSINE RECEPTOR_A1_Mus musculus-21662665
8GPCR0233ADRENOCEPTOR (A2-ADRENOCEPTOR)_A2A(Adrenoceptor)_Mus musculus8662784
9GPCR0240ADRENOCEPTOR (A2-ADRENOCEPTOR)_A2B(Adrenoceptor)_Mus musculus-22164221
10GPCR0242ADRENOCEPTOR (A2-ADRENOCEPTOR)_A2B(Adrenoceptor)_Mus musculus-32164221
11GPCR0271ADRENOCEPTOR (A2-ADRENOCEPTOR)_A2B(Adrenoceptor)_Mus musculus-12164221
12GPCR0301ADRENOCEPTOR (A2-ADRENOCEPTOR)_A2C(Adrenoceptor)_Mus musculus2842764
13GPCR0191ADENOSINE RECEPTOR_A3_Mus musculus1323836
14GPCR0991LEUKOTRIENE RECEPTOR_ALX_Mus musculus9054386
15GPCR0445APJ RECEPTOR_Apelin_Mus musculus9792798
16GPCR0409ANGIOTENSIN RECEPTOR_AT1_Mus musculus-21310139
17GPCR0421ANGIOTENSIN RECEPTOR_AT1_Mus musculus-11310139
18GPCR0440ANGIOTENSIN RECEPTOR_AT2_Mus musculus8663053
19GPCR0400ADRENOCEPTOR (B-ADRENOCEPTOR)_B3(Adrenoceptor)_Mus musculus9363896
20GPCR0993LEUKOTRIENE RECEPTOR_BLT_Mus musculus9177352
21GPCR0704CHEMOTACTIC PEPTIDE RECEPTOR_C3A_Mus musculus8702752
22GPCR0714CHEMOTACTIC PEPTIDE RECEPTOR_C5A_Mus musculus7887933
23GPCR2636EXTRACELLULAR CALCIUM-SENSING RECEPTOR_CASR_Mus musculus11152759
24GPCR0538CANNABINOID RECEPTOR_CB1_Mus musculus-12165569
25GPCR0545CANNABINOID RECEPTOR_CB1_Mus musculus-22165569
26GPCR0547CANNABINOID RECEPTOR_CB2_Mus musculus7689702
27GPCR0553CHEMOKINE RECEPTOR (CC)_CCR1_Mus musculus-17679328
28GPCR0555CHEMOKINE RECEPTOR (CC)_CCR1_Mus musculus-27679328
29GPCR0557CHEMOKINE RECEPTOR (CC)_CCR10_Mus musculus10781587
30GPCR0563CHEMOKINE RECEPTOR (CC)_CCR2_Mus musculus8530354
31GPCR0567CHEMOKINE RECEPTOR (CC)_CCR3_Mus musculus8631813
32GPCR0570CHEMOKINE RECEPTOR (CC)_CCR4_Mus musculus9169480
33GPCR0591CHEMOKINE RECEPTOR (CC)_CCR5_Mus musculus8639485
34GPCR0593CHEMOKINE RECEPTOR (CC)_CCR6_Mus musculus9294137
35GPCR0596CHEMOKINE RECEPTOR (CC)_CCR7_Mus musculus9153236
36GPCR0599CHEMOKINE RECEPTOR (CC)_CCR8_Mus musculus9207005
37GPCR0602CHEMOKINE RECEPTOR (CC)_CCR9_Mus musculus-110229797
38GPCR0605CHEMOKINE RECEPTOR (CC)_CCR9_Mus musculus-210229797
39GPCR0609CHEMOKINE RECEPTOR (CX3C)_CX3CR1_Mus musculus9390561
40GPCR0631CHEMOKINE RECEPTOR (CX3C)_CXCR2_Mus musculus1891716
41GPCR0633CHEMOKINE RECEPTOR (CX3C)_CXCR3_Mus musculus9653165
42GPCR0635CHEMOKINE RECEPTOR (CX3C)_CXCR4_Mus musculus8629022
43GPCR0691CHEMOKINE RECEPTOR (CX3C)_CXCR5_Mus musculus11882900
44GPCR0700CHEMOKINE RECEPTOR (CX3C)_CXR1_Mus musculus9632725
45GPCR0790DOPAMINE RECEPTOR_D2_Mus musculus2974511
46GPCR0793DOPAMINE RECEPTOR_D3_Mus musculus1975644
47GPCR0801DOPAMINE RECEPTOR_D4_Mus musculus1840645
48GPCR1882OPIOID AND OPIOID-LIKE RECEPTOR_DELTA OPIOID PEPTIDE (DOR)_Mus musculus1335167
49GPCR2430PROSTANOID RECEPTOR_EP3_Mus musculus11095474
50GPCR0823ENDOTHELIN RECEPTOR_ET-B_Mus musculus1848367
51GPCR0730CHEMOTACTIC PEPTIDE RECEPTOR_FMLP_Mus musculus11160182
52GPCR2728FRIZZLED_Frizzled-1_Mus musculus11563835
53GPCR0852GLYCOPROTEIN HORMONE RECEPTOR_FSH RECEPTOR_Mus musculus9139796
54GPCR2642GABA RECEPTOR_GABA-B-R1_Mus musculus9872315
55GPCR0832GALANIN RECEPTOR_GAL1_Mus musculus7524088
56GPCR0837GALANIN RECEPTOR_GAL2_Mus musculus9685625
57GPCR0839GALANIN RECEPTOR_GAL3_Mus musculus9722565
58GPCR0980HISTAMINE RECEPTOR_H3_Mus musculus10347254
59GPCR0984HISTAMINE RECEPTOR_H4_Mus musculus10973974
60GPCR1886OPIOID AND OPIOID-LIKE RECEPTOR_KAPPA OPIOID PEPTIDE (KOR)_Mus musculus-27624359
61GPCR1892OPIOID AND OPIOID-LIKE RECEPTOR_KAPPA OPIOID PEPTIDE (KOR)_Mus musculus-17624359
62GPCR1009LYSOPHOSPHOLIPID RECEPTOR_LPA1_Mus musculus9070858
63GPCR1011LYSOPHOSPHOLIPID RECEPTOR_LPA2_Mus musculus9525886
64GPCR1016LYSOPHOSPHOLIPID RECEPTOR_LPA3_Mus musculus12069829
65GPCR0877GLYCOPROTEIN HORMONE RECEPTOR_LSH RECEPTOR_Mus musculus1516719
66GPCR0134ACETYLCHOLINE RECEPTOR (MUSCARINIC)_M2_Mus musculus3443095
67GPCR0151ACETYLCHOLINE RECEPTOR (MUSCARINIC)_M4_Mus musculus3037705
68GPCR2796MELANIN-CONCENTRATING HORMONE RECEPTOR_MCHR1_Mus musculus10559938
69GPCR2653GLUTAMATE RECEPTOR (METABOTROPIC)_MGLU3_Mus musculus1309649
70GPCR2665GLUTAMATE RECEPTOR (METABOTROPIC)_MGLU8_Mus musculus9473604
71GPCR1214MELATONIN RECEPTOR_MT1_Mus musculus7946354
72GPCR1893OPIOID AND OPIOID-LIKE RECEPTOR_MU OPIOID PEPTIDE (MOR)_Mus musculus-88393525
73GPCR1894OPIOID AND OPIOID-LIKE RECEPTOR_MU OPIOID PEPTIDE (MOR)_Mus musculus-78393525
74GPCR1895OPIOID AND OPIOID-LIKE RECEPTOR_MU OPIOID PEPTIDE (MOR)_Mus musculus-108393525
75GPCR1896OPIOID AND OPIOID-LIKE RECEPTOR_MU OPIOID PEPTIDE (MOR)_Mus musculus-98393525
76GPCR1899OPIOID AND OPIOID-LIKE RECEPTOR_MU OPIOID PEPTIDE (MOR)_Mus musculus-38393525
77GPCR1900OPIOID AND OPIOID-LIKE RECEPTOR_MU OPIOID PEPTIDE (MOR)_Mus musculus-68393525
78GPCR1903OPIOID AND OPIOID-LIKE RECEPTOR_MU OPIOID PEPTIDE (MOR)_Mus musculus-28393525
79GPCR1905OPIOID AND OPIOID-LIKE RECEPTOR_MU OPIOID PEPTIDE (MOR)_Mus musculus-18393525
80GPCR1906OPIOID AND OPIOID-LIKE RECEPTOR_MU OPIOID PEPTIDE (MOR)_Mus musculus-58393525
81GPCR1910OPIOID AND OPIOID-LIKE RECEPTOR_MU OPIOID PEPTIDE (MOR)_Mus musculus-48393525
82GPCR1282NICOTINIC ACID RECEPTOR_NICOTINIC ACID_Mus musculus15183629 | 12563315
83GPCR1915OPIOID AND OPIOID-LIKE RECEPTOR_N/OFQ RECEPTOR_Mus musculus15019559
84GPCR2552VASOPRESSIN AND OXYTOCIN RECEPTOR_OT_Mus musculus1313946
85GPCR2386P2Y RECEPTOR_P2Y12_Mus musculus11196645
86GPCR2453PROTEASE-ACTIVATED RECEPTOR_PAR1_Mus musculus10644723
87GPCR2459PROTEASE-ACTIVATED RECEPTOR_PAR2_Mus musculus15082510
88GPCR2462PROTEASE-ACTIVATED RECEPTOR_PAR3_Mus musculus15082510
89GPCR2466PROTEASE-ACTIVATED RECEPTOR_PAR4_Mus musculus15082510
90GPCR2413PLATELET ACTIVATING FACTOR (PAF) RECEPTOR_PLATELET ACTIVATING FACTOR (PAF) RECEPTOR_Mus musculus7876256
91GPCR1023LYSOPHOSPHOLIPID RECEPTOR_S1P1_Mus musculus-19488656
92GPCR1028LYSOPHOSPHOLIPID RECEPTOR_S1P1_Mus musculus-39488656
93GPCR1074LYSOPHOSPHOLIPID RECEPTOR_S1P1_Mus musculus-29488656
94GPCR1087LYSOPHOSPHOLIPID RECEPTOR_S1P2_Mus musculus10488065
95GPCR1096LYSOPHOSPHOLIPID RECEPTOR_S1P3_Mus musculus9409733
96GPCR1102LYSOPHOSPHOLIPID RECEPTOR_S1P5_Mus musculus10799507
97GPCR1105LYSOPHOSPHOLIPID RECEPTOR_S1P-like_Mus musculus-312220620
98GPCR1114LYSOPHOSPHOLIPID RECEPTOR_S1P-like_Mus musculus-112220620
99GPCR1123LYSOPHOSPHOLIPID RECEPTOR_S1P-like_Mus musculus-212220620
100GPCR1128LYSOPHOSPHOLIPID RECEPTOR_S1P-like_Mus musculus-412220620
101GPCR2788RELAXIN RECEPTOR_SALPR_Mus musculus-210806363
102GPCR2789RELAXIN RECEPTOR_SALPR_Mus musculus-110806363
103GPCR2802SMOOTHENED_smoothened_Mus musculus10835429
104GPCR1106LYSOPHOSPHOLIPID RECEPTOR_SPC/LPC_Mus musculus-512069813
105GPCR1110LYSOPHOSPHOLIPID RECEPTOR_SPC/LPC_Mus musculus-112069813
106GPCR1116LYSOPHOSPHOLIPID RECEPTOR_SPC/LPC_Mus musculus-412069813
107GPCR1133LYSOPHOSPHOLIPID RECEPTOR_SPC/LPC_Mus musculus-312069813
108GPCR1136LYSOPHOSPHOLIPID RECEPTOR_SPC/LPC_Mus musculus-212069813
109GPCR2475SOMATOSTATIN RECEPTOR_SST1_Mus musculus1346068
110GPCR2480SOMATOSTATIN RECEPTOR_SST2_Mus musculus7622071
111GPCR2485SOMATOSTATIN RECEPTOR_SST3_Mus musculus1337145
112GPCR2489SOMATOSTATIN RECEPTOR_SST4_Mus musculus8483934
113GPCR2490SOMATOSTATIN RECEPTOR_SST5_Mus musculus-18373420
114GPCR2491SOMATOSTATIN RECEPTOR_SST5_Mus musculus-28373420
115GPCR0897GLYCOPROTEIN HORMONE RECEPTOR_TSH RECEPTOR_Mus musculus-18552586
116GPCR1245NEUROPEPTIDE Y RECEPTOR_Y1_Mus musculus1321422
117GPCR1256NEUROPEPTIDE Y RECEPTOR_Y2_Mus musculus7559383
118GPCR1265NEUROPEPTIDE Y RECEPTOR_Y4_Mus musculus7592911
119GPCR1268NEUROPEPTIDE Y RECEPTOR_Y5_Mus musculus8700207
120GPCR1271NEUROPEPTIDE Y RECEPTOR_Y6_Mus musculus8700207



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athina University of Athens
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 Dept. of Cell Biology and Biophysics
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