gpDB: a database of G-proteins and their interaction with GPCRs
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gpDB::GPCR View
Entry 1 of 1 :: GPCR1256 ::
CLASS CLASS A (RHODOPSIN LIKE)
FAMILY NEUROPEPTIDE Y RECEPTOR
SUBFAMILY Y2

Cross References:
UniProt P97295 EMBL D86238
InterPro IPR000276 | IPR001358 | IPR000611 GPCRDB npy2r_mouse
PRINTS PR00237 | PR01014 | PR01012 PFAM PF00001

Details:
NAME NEUROPEPTIDE Y RECEPTOR_Y2_Mus musculus
DESCRIPTION Neuropeptide Y receptor type 2 (NPY2-R) (NPY-Y2 receptor).
SPECIES Mus musculus COMMON NAME Mouse NCBI Taxonomy 10090
GENE Npy2r
SEQUENCE
MVLKMGPVGAEADENQTVEVKVEPYGPGHTTPRGELPPDPEPELIDSTKLVEVQVILILA
YCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEW
KMGPVLCHLVPYAQGLAVQVSTITLTVIALDRHRCIVYHLESKISKRISFLIIGLAWGIS
ALLASPLAIFREYSLIEIIPDFEIVACTEKWPGEEKSVYGTVYSLSTLLILYVLPLGIIS
FSYTRIWSKLRNHVSPGAASDHYHQRRHKMTKMLVCVVVVFAVSWLPLHAFQLAVDIDSH
VLDLKEYKLIFTVFHIIAMCSTFANPLLYGWMNSNYRKAFLSAFRCEQRLDAIHSEVSMT
FKAKKNLEVKKNNGPTDSFSEATNV
FRAGMENT NO

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Dimerization:
HOMODIMER INFORMATION There is experimental evidence for homo-dimerization METHOD Fluorescence Resonance Energy Transfer (FRET) REFERENCES 12524448

Coupling with G-proteins:
Family:Gi/o REFERENCES:7559383
1GPR0021Galpha-o1-Mus musculus
2GPR0227Galpha-i2-Mus musculus-2
3GPR0289Galpha-i1-Mus musculus
4GPR0331Galpha-i2-Mus musculus-1
5GPR0385Galpha-i3-Mus musculus


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athina University of Athens
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Dept. of Cell Biology and Biophysics
Biophysics
& Bioinformatics
Laboratory