gpDB: a database of G-proteins and their interaction with GPCRs
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gpDB::GPCR View
Entry 1 of 1 :: GPCR0440 ::
CLASS CLASS A (RHODOPSIN LIKE)
FAMILY ANGIOTENSIN RECEPTOR
SUBFAMILY AT2

Cross References:
UniProt P35374 EMBL S67465 | U04828 | U00766 | L32840 | U11073 | AK086334 | BC003811
InterPro IPR000147 | IPR000248 | IPR001186 | IPR000276 GPCRDB agtr2_mouse
GENEID 11609
PRINTS PR00241 | PR00636 | PR00993 | PR00237 PFAM PF00001

Details:
NAME ANGIOTENSIN RECEPTOR_AT2_Mus musculus
DESCRIPTION Type-2 angiotensin II receptor (AT2).
SPECIES Mus musculus COMMON NAME Mouse NCBI Taxonomy 10090
GENE Agtr2
SEQUENCE
MKDNFSFAATSRNITSSRPFDNLNATGTNESAFNCSHKPSDKHLEAIPVLYYMIFVIGFA
VNIVVVSLFCCQKGPKKVSSIYIFNLALADLLLLATLPLWATYYSYRYDWLFGPVMCKVF
GSFLTLNMFASIFFITCMSVDRYQSVIYPFLSQRRNPWQASYVVPLVWCMACLSSLPTFY
FRDVRTIEYLGVNACIMAFPPEKYAQWSAGIALMKNILGFIIPLIFIATCYFGIRKHLLK
TNSYGKNRITRDQVLKMAAAVVLAFIICWLPFHVLTFLDALTWMGIINSCEVIAVIDLAL
PFAILLGFTNSCVNPFLYCFVGNRFQQKLRSVFRVPITWLQGKRETMSCRKGSSLREMDT
FVS
FRAGMENT NO

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Dimerization:
HETERODIMER INFORMATION Forms heterodimer with AT1 Receptor. After the dimerization the AT2 receptor antagonizes function of the AT1 receptor METHOD Immunoprecipitation REFERENCES 11507095

Coupling with G-proteins:
Family:Gi/o REFERENCES:8663053
1GPR0021Galpha-o1-Mus musculus
2GPR0227Galpha-i2-Mus musculus-2
3GPR0289Galpha-i1-Mus musculus
4GPR0331Galpha-i2-Mus musculus-1
5GPR0385Galpha-i3-Mus musculus


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