gpDB: a database of G-proteins and their interaction with GPCRs
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gpDB::GPCR View
Entry 1 of 1 :: GPCR0030 ::
CLASS CLASS A (RHODOPSIN LIKE)
FAMILY 5-HYDROXYTRYPTAMINE RECEPTOR
SUBFAMILY 5-HT-1B

Cross References:
UniProt P28334 EMBL Z11597 | M85151
InterPro IPR002147 | IPR002231 | IPR000276 GPCRDB 5ht1b_mouse
GENEID 15551
PRINTS PR00513 | PR01101 | PR00237 PFAM PF00001

Details:
NAME 5-HYDROXYTRYPTAMINE RECEPTOR_5-HT-1B_Mus musculus
DESCRIPTION 5-hydroxytryptamine receptor 1B (5-HT-1B) (Serotonin receptor 1B) (5-HT1B).
SPECIES Mus musculus COMMON NAME Mouse NCBI Taxonomy 10090
GENE Htr1b | 5ht1b
SEQUENCE
MEEQGIQCAPPPPAASQTGVPLTNLSHNCSADGYIYQDSIALPWKVLLVALLALITLATT
LSNAFVIATVYRTRKLHTPANYLIASLAVTDLLVSILVMPISTMYTVTGRWTLGQVVCDF
WLSSDITCCTASIMHLCVIALDRYWAITDAVEYSAKRTPKRAAIMIVLVWVFSISISLPP
FFWRQAKAEEEMLDCFVNTDHVLYTVYSTVGAFYLPTLLLIALYGRIYVEARSRILKQTP
NKTGKRLTRAQLITDSPGSTSSVTSINSRAPDVPSESGSPVYVNQVKVRVSDALLEKKKL
MAARERKATKTLGIILGAFIVCWLPFFIISLVMPICKDACWFHMAIFDFFNWLGYLNSLI
NPIIYTMSNEDFKQAFHKLIRFKCAG
FRAGMENT NO

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Dimerization:
HOMODIMER INFORMATION There is experimental evidence for homo-dimerization METHOD Immunoprecipitation REFERENCES 10452531
HETERODIMER INFORMATION Forms functional heterodimers when co-expressed with 5-HT-1D Receptor. METHOD Immunoprecipitation REFERENCES 10452531

Coupling with G-proteins:
Family:Gi/o REFERENCES:1351684
1GPR0021Galpha-o1-Mus musculus
2GPR0227Galpha-i2-Mus musculus-2
3GPR0289Galpha-i1-Mus musculus
4GPR0331Galpha-i2-Mus musculus-1
5GPR0385Galpha-i3-Mus musculus


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athina University of Athens
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Biophysics
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Laboratory