gpDB: a database of G-proteins and their interaction with GPCRs
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gpDB::GPCR View
Entry 1 of 1 :: GPCR2802 ::
CLASS FRIZZLED/SMOOTHENED
FAMILY SMOOTHENED
SUBFAMILY smoothened

Cross References:
UniProt P56726
InterPro IPR000539 | IPR000024 | IPR015526 | IPR000832 GPCRDB smo_mouse
PRINTS PR00489 PFAM PF01534 | PF01392

Details:
NAME SMOOTHENED_smoothened_Mus musculus
DESCRIPTION Smoothened homolog precursor (SMO).
SPECIES Mus musculus COMMON NAME Mouse NCBI Taxonomy 10090
GENE Smo | Smoh
SEQUENCE
MAAGRPVRGPELAPRRLLQLLLLVLLGGPGRGAALSGNVTGPGPHSASGSSRRNVPVTSP
PPPLLSHCGRAAHCEPLRYNVCLGSALPYGATTTLLAGDSDSQEEAHGKLVLWSGLRNAP
RCWAVIQPLLCAVYMPKCENDRVELPSRTLCQATRGPCAIVERERGWPDFLRCTPDHFPE
GCPNEVQNIKFNSSGQCEAPLVRTDNPKSWYEDVEGCGIQCQNPLFTEAEHQDMHSYIAA
FGAVTGLCTLFTLATFVADWRNSNRLPAVILFYVNACFFVGSIGWLAQFMDGARREIVCR
ADGTMRFGEPTSSETLSCVIIFVIVYYALMAGVVWFVVLTYAWHTSFKALGTTYQPLSGK
TSYFHLLTWSLPFVLTVAILAVAQVDGDSVSGICFVGYKNYRYRAGFVLAPIGLVLIVGG
YFLIRGVMTLFSIKSNHPGLLSEKAASKINETMLRLGIFGFLAFGFVLITFSCHFYDFFN
QAEWERSFRDYVLCQANVTIGLPTKKPIPDCEIKNRPSLLVEKINLFAMFGTGIAMSTWV
WTKATLLIWRRTWCRLTGHSDDEPKRIKKSKMIAKAFSKRRELLQNPGQELSFSMHTVSH
DGPVAGLAFDLNEPSADVSSAWAQHVTKMVARRGAILPQDVSVTPVATPVPPEEQANMWL
VEAEISPELEKRLGRKKKRRKRKKEVCPLGPAPELHHSAPVPATSAVPRLPQLPRQKCLV
AANAWGTGESCRQGAWTLVSNPFCPEPSPHQDPFLPGASAPRVWAQGRLQGLGSIHSRTN
LMEAEILDADSDF
FRAGMENT NO

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Coupling with G-proteins:
Family:G12/13 REFERENCES:14723707
1GPR0035Galpha-12-Mus musculus
2GPR0038Galpha-13-Mus musculus-2
3GPR0323Galpha-13-Mus musculus-3
4GPR0380Galpha-13-Mus musculus-1
Family:Gi/o REFERENCES:10835429
5GPR0021Galpha-o1-Mus musculus
6GPR0227Galpha-i2-Mus musculus-2
7GPR0289Galpha-i1-Mus musculus
8GPR0331Galpha-i2-Mus musculus-1
9GPR0385Galpha-i3-Mus musculus


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athina University of Athens
Faculty of Biology
Dept. of Cell Biology and Biophysics
Biophysics
& Bioinformatics
Laboratory