gpDB: a database of G-proteins and their interaction with GPCRs
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gpDB::GPCR View
Entry 1 of 1 :: GPCR2552 ::
CLASS CLASS A (RHODOPSIN LIKE)
FAMILY VASOPRESSIN AND OXYTOCIN RECEPTOR
SUBFAMILY OT

Cross References:
UniProt P97926 EMBL D86599 | D86631
InterPro IPR000276 | IPR002062 | IPR001817 GPCRDB oxyr_mouse
PRINTS PR00237 | PR00665 | PR00896 PFAM PF00001

Details:
NAME VASOPRESSIN AND OXYTOCIN RECEPTOR_OT_Mus musculus
DESCRIPTION Oxytocin receptor (OT-R).
SPECIES Mus musculus COMMON NAME Mouse NCBI Taxonomy 10090
GENE Oxtr
SEQUENCE
MEGTPAANWSIELDLGSGVPPGAEGNLTAGPPRRNEALARVEVAVLCLILFLALSGNACV
LLALRTTRHKHSRLFFFMKHLSIADLVVAVFQVLPQLLWDITFRFYGPDLLCRLVKYLQV
VGMFASTYLLLLMSLDRCLAICQPLRSLRRRTDRLAVLATWLGCLVASVPQVHIFSLREV
ADGVFDCWAVFIQPWGPKAYVTWITLAVYIVPVIVLAACYGLISFKIWQNLRLKTAAAAA
AAEGSDAAGGAGRAALARVSSVKLISKAKIRTVKMTFIIVLAFIVCWTPFFFVQMWSVWD
VNAPKEASAFIIAMLLASLNSCCNPWIYMLFTGHLFHELVQRFLCCSARYLKGSRPGETS
ISKKSNSSTFVLSRCSSSQRSCSQPSSA
FRAGMENT NO

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Dimerization:
HOMODIMER INFORMATION There is experimental evidence for homo-dimerization METHOD Bioluminescence Resonance Energy Transfer (BRET) REFERENCES 12554793
HETERODIMER INFORMATION Forms functional heterodimers with V2 Receptors METHOD Bioluminescence Resonance Energy Transfer (BRET) REFERENCES 12554793
HETERODIMER INFORMATION Forms functional heterodimers with V1A Receptors METHOD Bioluminescence Resonance Energy Transfer (BRET) REFERENCES 12554793

Coupling with G-proteins:
Family:Gi/o REFERENCES:1313946
1GPR0021Galpha-o1-Mus musculus
2GPR0227Galpha-i2-Mus musculus-2
3GPR0289Galpha-i1-Mus musculus
4GPR0331Galpha-i2-Mus musculus-1
5GPR0385Galpha-i3-Mus musculus
Family:Gq/11 REFERENCES:1313946
6GPR0031Galpha-11-Mus musculus-2
7GPR0240Galpha-q-Mus musculus
8GPR0360Galpha-11-Mus musculus-1


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athina University of Athens
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Biophysics
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Laboratory