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gpDB::GPCR View
Entry 1 of 1 :: GPCR1892 ::
CLASS CLASS A (RHODOPSIN LIKE)
FAMILY OPIOID AND OPIOID-LIKE RECEPTOR
SUBFAMILY KAPPA OPIOID PEPTIDE (KOR)

Cross References:
UniProt P33534 EMBL L11065 | D31665 | S77872 | S77868 | S77869 | S81111
InterPro IPR000276 | IPR000452 | IPR001418 GPCRDB oprk_mouse
GENEID 18387
PRINTS PR00237 | PR00532 | PR00384 PFAM PF00001

Details:
NAME OPIOID AND OPIOID-LIKE RECEPTOR_KAPPA OPIOID PEPTIDE (KOR)_Mus musculus-1
DESCRIPTION Kappa-type opioid receptor (KOR-1) (MSL-1).
SPECIES Mus musculus COMMON NAME Mouse NCBI Taxonomy 10090
GENE Oprk1
SEQUENCE
MESPIQIFRGDPGPTCSPSACLLPNSSSWFPNWAESDSNGSVGSEDQQLESAHISPAIPV
IITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSAVYL
MNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINI
CIWLLASSVGISAIVLGGTKVREDVDVIECSLQFPDDEYSWWDLFMKICVFVFAFVIPVL
IIIVCYTLMILRLKSVRLLSGSREKDRNLRRITKLVLVVVAVFIICWTPIHIFILVEALG
STSHSTAALSSYYFCIALGYTNSSLNPVLYAFLDENFKRCFRDFCFPIKMRMERQSTNRV
RNTVQDPASMRDVGGMNKPV
FRAGMENT NO

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Dimerization:
HOMODIMER INFORMATION There is experimental evidence for homo-dimerization METHOD Immunoprecipitation REFERENCES 10385123
HETERODIMER INFORMATION Forms heterodimers with delta Opioid Peptide Receptor. Dimerization results in altered ligand binding, potentiated signalling and altered internalization METHOD Immunoprecipitation REFERENCES 10385123
HETERODIMER INFORMATION Forms heterodimers with B2 Adrenoceptors. Heterodimerization results in altered internalization and MAPK signalling METHOD Immunoprecipitation REFERENCES 11134510

Scaffold:
TYPE NHERF1( Na+/H+ exchange regulatory factor) /EBP50( ezrin-radixin-moesin binding phosphoprotein 50-kD protein) REFERENCES 12004055

Coupling with G-proteins:
Family:Gi/o REFERENCES:7624359
1GPR0021Galpha-o1-Mus musculus
2GPR0227Galpha-i2-Mus musculus-2
3GPR0289Galpha-i1-Mus musculus
4GPR0331Galpha-i2-Mus musculus-1
5GPR0385Galpha-i3-Mus musculus


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athina University of Athens
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Dept. of Cell Biology and Biophysics
Biophysics
& Bioinformatics
Laboratory