gpDB::G-protein View

CLASS	Galpha
FAMILY	Gs
SUBFAMILY	Galpha-s
TYPE	Galpha-s

Cross References:
UniProt	Q5JWF2 \| A2A2S3 \| O75684 \| O75685 \| Q5JW67 \| Q5JWF1 \| Q9NY42	EMBL	AL109840 \| AL121917 \| AL132655 \| AL109840 \| AL121917 \| AL132655 \| AL121917 \| AL109840 \| AL132655 \| AL121917 \| AL109840 \| AL132655 \| AL132655 \| AL109840 \| AL121917 \| AL132655 \| AL109840 \| AL121917 \| AL132655 \| AJ251760 \| AJ224867 \| AJ224868 \| AY898804
InterPro	IPR001019 \| IPR000367 \| IPR011025
PRODOM	PD000281
GENEID	2778	MIM	139320 \| 219080 \| 603233
PRINTS	PR00318 \| PR00443	PFAM	PF00503

Details:
NAME	Galpha-s-Homo sapiens-3
DESCRIPTION	Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas(Adenylate cyclase-stimulating G alpha protein) (Extra large alphasprotein) (XLalphas).
SPECIES	Homo sapiens	COMMON NAME	Human	NCBI Taxonomy	9606
POST TRANSLATION MODIFICATIONS	null	GENE	GNAS \| GNAS1
SEQUENCE	MGVRNCLYGNNMSGQRDIPPEIGEQPEQPPLEAPGAAAPGAGPSPAEEMETEPPHNEPIP VENDGEACGPPEVSRPNFQVLNPAFREAGAHGSYSPPPEEAMPFEAEQPSLGGFWPTLEQ PGFPSGVHAGLEAFGPALMEPGAFSGARPGLGGYSPPPEEAMPFEFDQPAQRGCSQLLLQ VPDLAPGGPGAAGVPGAPPEEPQALRPAKAGSRGGYSPPPEETMPFELDGEGFGDDSPPP GLSRVIAQVDGSSQFAAVAASSAVRLTPAANAPPLWVPGAIGSPSQEAVRPPSNFTGSSP WMEISGPPFEIGSAPAGVDDTPVNMDSPPIALDGPPIKVSGAPDKRERAERPPVEEEAAE MEGAADAAEGGKVPSPGYGSPAAGAASADTAARAAPAAPADPDSGATPEDPDSGTAPADP DSGAFAADPDSGAAPAAPADPDSGAAPDAPADPDSGAAPDAPADPDAGAAPEAPAAPAAA ETRAAHVAPAAPDAGAPTAPAASATRAAQVRRAASAAPASGARRKIHLRPPSPEIQAADP PTPRPTRASAWRGKSESSRGRRVYYDEGVASSDDDSSGDESDDGTSGCLRWFQHRRNRRR RKPQRNLLRNFLVQAFGGCFGRSESPQPKASRSLKVKKVPLAEKRRQMRKEALEKRAQKR AEKKRSKLIDKQLQDEKMGYMCTHRLLLLGAGESGKSTIVKQMRILHVNGFNGEGGEEDP QAARSNSDGEKATKVQDIKNNLKEAIETIVAAMSNLVPPVELANPENQFRVDYILSVMNV PDFDFPPEFYEHAKALWEDEGVRACYERSNEYQLIDCAQYFLDKIDVIKQADYVPSDQDL LRCRVLTSGIFETKFQVDKVNFHMFDVGGQRDERRKWIQCFNDVTAIIFVVASSSYNMVI REDNQTNRLQEALNLFKSIWNNRWLRTISVILFLNKQDLLAEKVLAGKSKIEDYFPEFAR YTTPEDATPEPGEDPRVTRAKYFIRDEFLRISTASGDGRHYCYPHFTCAVDTENIRRVFN DCRDIIQRMHLRQYELL				FRAGMENT	NO
FUNCTION	Guanine nucleotide-binding proteins (G proteins) ares involved as modulators or transducers in various transmembranes signaling systems

Effectors:
1	EFF0002	Adenylate cyclase-1-Homo sapiens-1	Stimulation	15251227 \| 15922020 \| 14993377 \| 11376933
2	EFF0003	Adenylate cyclase-1-Homo sapiens-2	Stimulation	15251227 \| 15922020 \| 14993377 \| 11376933
3	EFF0006	Adenylate cyclase-2-Homo sapiens-1	Stimulation	15251227 \| 15922020 \| 14993377 \| 11376933
4	EFF0007	Adenylate cyclase-2-Homo sapiens-2	Stimulation	15251227 \| 15922020 \| 14993377 \| 11376933
5	EFF0013	Adenylate cyclase-3-Homo sapiens	Stimulation	15251227 \| 15922020 \| 14993377 \| 11376933
6	EFF0020	Adenylate cyclase-4-Homo sapiens-1	Stimulation	15251227 \| 15922020 \| 14993377 \| 11376933
7	EFF0021	Adenylate cyclase-4-Homo sapiens-2	Stimulation	15251227 \| 15922020 \| 14993377 \| 11376933
8	EFF0030	Adenylate cyclase-5-Homo sapiens	Stimulation	15251227 \| 15922020 \| 14993377 \| 11376933
9	EFF0039	Adenylate cyclase-6-Homo sapiens	Stimulation	15251227 \| 15922020 \| 14993377 \| 11376933
10	EFF0045	Adenylate cyclase-7-Homo sapiens	Stimulation	15251227 \| 15922020 \| 14993377 \| 11376933
11	EFF0055	Adenylate cyclase-8-Homo sapiens-1	Stimulation	15251227 \| 15922020 \| 14993377 \| 11376933
12	EFF0056	Adenylate cyclase-8-Homo sapiens-2	Stimulation	15251227 \| 15922020 \| 14993377 \| 11376933
13	EFF0062	Adenylate cyclase-9-Homo sapiens	Stimulation	15251227 \| 15922020 \| 14993377 \| 11376933
14	EFF0705	RGS PX1-Homo sapiens	Stimulation	15251227
15	EFF0852	Src tyrosine kinase-Homo sapiens-1	Stimulation	11007482 \| 15251227 \| 12209124
16	EFF0853	Src tyrosine kinase-Homo sapiens-2	Stimulation	11007482 \| 15251227 \| 12209124
17	EFF0854	Src tyrosine kinase-Homo sapiens-3	Stimulation	11007482 \| 15251227 \| 12209124
18	EFF0856	Src tyrosine kinase-Homo sapiens-5	Stimulation	11007482 \| 15251227 \| 12209124
19	EFF0857	Src tyrosine kinase-Homo sapiens-4	Stimulation	11007482 \| 15251227 \| 12209124
20	EFF1126	Tubulin-Homo sapiens-1	Stimulation of GTPase activity	10224115 \| 15251227 \| 16380086
21	EFF1127	Tubulin-Homo sapiens-10	Stimulation of GTPase activity	10224115 \| 15251227 \| 16380086
22	EFF1128	Tubulin-Homo sapiens-11	Stimulation of GTPase activity	10224115 \| 15251227 \| 16380086
23	EFF1129	Tubulin-Homo sapiens-12	Stimulation of GTPase activity	10224115 \| 15251227 \| 16380086
24	EFF1130	Tubulin-Homo sapiens-13	Stimulation of GTPase activity	10224115 \| 15251227 \| 16380086
25	EFF1131	Tubulin-Homo sapiens-14	Stimulation of GTPase activity	10224115 \| 15251227 \| 16380086
26	EFF1132	Tubulin-Homo sapiens-15	Stimulation of GTPase activity	10224115 \| 15251227 \| 16380086
27	EFF1133	Tubulin-Homo sapiens-16	Stimulation of GTPase activity	10224115 \| 15251227 \| 16380086
28	EFF1134	Tubulin-Homo sapiens-17	Stimulation of GTPase activity	10224115 \| 15251227 \| 16380086
29	EFF1135	Tubulin-Homo sapiens-18	Stimulation of GTPase activity	10224115 \| 15251227 \| 16380086
30	EFF1136	Tubulin-Homo sapiens-19	Stimulation of GTPase activity	10224115 \| 15251227 \| 16380086
31	EFF1137	Tubulin-Homo sapiens-2	Stimulation of GTPase activity	10224115 \| 15251227 \| 16380086
32	EFF1138	Tubulin-Homo sapiens-20	Stimulation of GTPase activity	10224115 \| 15251227 \| 16380086
33	EFF1139	Tubulin-Homo sapiens-21	Stimulation of GTPase activity	10224115 \| 15251227 \| 16380086
34	EFF1140	Tubulin-Homo sapiens-22	Stimulation of GTPase activity	10224115 \| 15251227 \| 16380086
35	EFF1141	Tubulin-Homo sapiens-23	Stimulation of GTPase activity	10224115 \| 15251227 \| 16380086
36	EFF1143	Tubulin-Homo sapiens-25	Stimulation of GTPase activity	10224115 \| 15251227 \| 16380086
37	EFF1144	Tubulin-Homo sapiens-26	Stimulation of GTPase activity	10224115 \| 15251227 \| 16380086
38	EFF1145	Tubulin-Homo sapiens-27	Stimulation of GTPase activity	10224115 \| 15251227 \| 16380086
39	EFF1146	Tubulin-Homo sapiens-28	Stimulation of GTPase activity	10224115 \| 15251227 \| 16380086
40	EFF1148	Tubulin-Homo sapiens-3	Stimulation of GTPase activity	10224115 \| 15251227 \| 16380086
41	EFF1149	Tubulin-Homo sapiens-30	Stimulation of GTPase activity	10224115 \| 15251227 \| 16380086
42	EFF1150	Tubulin-Homo sapiens-31	Stimulation of GTPase activity	10224115 \| 15251227 \| 16380086
43	EFF1151	Tubulin-Homo sapiens-32	Stimulation of GTPase activity	10224115 \| 15251227 \| 16380086
44	EFF1152	Tubulin-Homo sapiens-33	Stimulation of GTPase activity	10224115 \| 15251227 \| 16380086
45	EFF1153	Tubulin-Homo sapiens-34	Stimulation of GTPase activity	10224115 \| 15251227 \| 16380086
46	EFF1154	Tubulin-Homo sapiens-35	Stimulation of GTPase activity	10224115 \| 15251227 \| 16380086
47	EFF1156	Tubulin-Homo sapiens-37	Stimulation of GTPase activity	10224115 \| 15251227 \| 16380086
48	EFF1157	Tubulin-Homo sapiens-38	Stimulation of GTPase activity	10224115 \| 15251227 \| 16380086
49	EFF1158	Tubulin-Homo sapiens-39	Stimulation of GTPase activity	10224115 \| 15251227 \| 16380086
50	EFF1159	Tubulin-Homo sapiens-4	Stimulation of GTPase activity	10224115 \| 15251227 \| 16380086
51	EFF1160	Tubulin-Homo sapiens-40	Stimulation of GTPase activity	10224115 \| 15251227 \| 16380086
52	EFF1162	Tubulin-Homo sapiens-42	Stimulation of GTPase activity	10224115 \| 15251227 \| 16380086
53	EFF1163	Tubulin-Homo sapiens-43	Stimulation of GTPase activity	10224115 \| 15251227 \| 16380086
54	EFF1164	Tubulin-Homo sapiens-44	Stimulation of GTPase activity	10224115 \| 15251227 \| 16380086
55	EFF1165	Tubulin-Homo sapiens-45	Stimulation of GTPase activity	10224115 \| 15251227 \| 16380086
56	EFF1166	Tubulin-Homo sapiens-46	Stimulation of GTPase activity	10224115 \| 15251227 \| 16380086
57	EFF1167	Tubulin-Homo sapiens-47	Stimulation of GTPase activity	10224115 \| 15251227 \| 16380086
58	EFF1168	Tubulin-Homo sapiens-48	Stimulation of GTPase activity	10224115 \| 15251227 \| 16380086
59	EFF1169	Tubulin-Homo sapiens-49	Stimulation of GTPase activity	10224115 \| 15251227 \| 16380086
60	EFF1170	Tubulin-Homo sapiens-5	Stimulation of GTPase activity	10224115 \| 15251227 \| 16380086
61	EFF1171	Tubulin-Homo sapiens-50	Stimulation of GTPase activity	10224115 \| 15251227 \| 16380086
62	EFF1173	Tubulin-Homo sapiens-52	Stimulation of GTPase activity	10224115 \| 15251227 \| 16380086
63	EFF1174	Tubulin-Homo sapiens-51	Stimulation of GTPase activity	10224115 \| 15251227 \| 16380086
64	EFF1175	Tubulin-Homo sapiens-41	Stimulation of GTPase activity	10224115 \| 15251227 \| 16380086
65	EFF1176	Tubulin-Homo sapiens-36	Stimulation of GTPase activity	10224115 \| 15251227 \| 16380086
66	EFF1177	Tubulin-Homo sapiens-29	Stimulation of GTPase activity	10224115 \| 15251227 \| 16380086
67	EFF1178	Tubulin-Homo sapiens-24	Stimulation of GTPase activity	10224115 \| 15251227 \| 16380086
68	EFF1179	Tubulin-Homo sapiens-6	Stimulation of GTPase activity	10224115 \| 15251227 \| 16380086
69	EFF1180	Tubulin-Homo sapiens-7	Stimulation of GTPase activity	10224115 \| 15251227 \| 16380086
70	EFF1181	Tubulin-Homo sapiens-8	Stimulation of GTPase activity	10224115 \| 15251227 \| 16380086
71	EFF1182	Tubulin-Homo sapiens-9	Stimulation of GTPase activity	10224115 \| 15251227 \| 16380086

Coupling with GPCRs:
1	GPCR0089	5-HYDROXYTRYPTAMINE RECEPTOR_5-HT-4_Homo sapiens	2849052
2	GPCR0101	5-HYDROXYTRYPTAMINE RECEPTOR_5-HT-6_Homo sapiens	8522988
3	GPCR0104	5-HYDROXYTRYPTAMINE RECEPTOR_5-HT-7_Homo sapiens	8397408
4	GPCR0182	ADENOSINE RECEPTOR_A2A_Homo sapiens-2	1662665
5	GPCR0185	ADENOSINE RECEPTOR_A2A_Homo sapiens-1	1662665
6	GPCR0232	ADRENOCEPTOR (A2-ADRENOCEPTOR)_A2A(Adrenoceptor)_Homo sapiens	8662784
7	GPCR0189	ADENOSINE RECEPTOR_A2B_Homo sapiens	11048721
8	GPCR2572	CALCITONIN, AMYLIN, CGRP, AND ADRENOMEDULIN RECEPTOR_ADRENOMEDULIN RECEPTOR_Homo sapiens	8549809
9	GPCR0304	ADRENOCEPTOR (B-ADRENOCEPTOR)_B1(Adrenoceptor)_Homo sapiens	2825170
10	GPCR0321	ADRENOCEPTOR (B-ADRENOCEPTOR)_B2(Adrenoceptor)_Homo sapiens-1	3041227
11	GPCR0384	ADRENOCEPTOR (B-ADRENOCEPTOR)_B2(Adrenoceptor)_Homo sapiens-2	3041227
12	GPCR0394	ADRENOCEPTOR (B-ADRENOCEPTOR)_B3(Adrenoceptor)_Homo sapiens	2570461
13	GPCR2577	CALCITONIN, AMYLIN, CGRP, AND ADRENOMEDULIN RECEPTOR_CALCITONIN_Homo sapiens	1331173
14	GPCR0737	CHOLECYSTOKININ AND GASTRIN RECEPTOR_CCK1_Homo sapiens	8503909
15	GPCR2580	CALCITONIN, AMYLIN, CGRP, AND ADRENOMEDULIN RECEPTOR_CGRP_Homo sapiens	2542467
16	GPCR2586	CORTICOTROPIN-RELEASING FACTOR RECEPTOR_CRF1_Homo sapiens	1280419
17	GPCR2592	CORTICOTROPIN-RELEASING FACTOR RECEPTOR_CRF2_Homo sapiens	8536644
18	GPCR0755	DOPAMINE RECEPTOR_D1_Homo sapiens	2144334
19	GPCR0807	DOPAMINE RECEPTOR_D5_Homo sapiens	1831904
20	GPCR2417	PROSTANOID RECEPTOR_DP_Homo sapiens	7512962
21	GPCR2425	PROSTANOID RECEPTOR_EP2_Homo sapiens	7910583
22	GPCR2432	PROSTANOID RECEPTOR_EP3_Homo sapiens	11095474
23	GPCR2436	PROSTANOID RECEPTOR_EP4_Homo sapiens	8016385
24	GPCR0814	ENDOTHELIN RECEPTOR_ET-A_Homo sapiens	1849646
25	GPCR0846	GLYCOPROTEIN HORMONE RECEPTOR_FSH RECEPTOR_Homo sapiens	9139796
26	GPCR2593	GASTRIC INHIBITORY POLYPEPTIDE (GIP) RECEPTOR_GIP-R_Homo sapiens	8243312
27	GPCR2601	GLUCAGON RECEPTOR_GLUCAGON-LIKE PEPTIDE RECEPTOR_Homo sapiens-1	1326760
28	GPCR2602	GLUCAGON RECEPTOR_GLUCAGON-LIKE PEPTIDE RECEPTOR_Homo sapiens-2	1326760
29	GPCR2598	GLUCAGON RECEPTOR_GLUCAGON RECEPTOR_Homo sapiens	8144028
30	GPCR0977	HISTAMINE RECEPTOR_H2_Homo sapiens	1703298
31	GPCR2447	PROSTANOID RECEPTOR_IP_Homo sapiens	7512962
32	GPCR2408	LYSOPHOSPHOLIPID RECEPTOR_LPA4_Homo sapiens	12724320
33	GPCR0871	GLYCOPROTEIN HORMONE RECEPTOR_LSH RECEPTOR_Homo sapiens	1516719
34	GPCR1158	MELANOCORTIN RECEPTOR_MC1_Homo sapiens	1516719
35	GPCR1181	MELANOCORTIN RECEPTOR_MC2_Homo sapiens	1325670
36	GPCR1188	MELANOCORTIN RECEPTOR_MC3_Homo sapiens	8463333
37	GPCR1195	MELANOCORTIN RECEPTOR_MC4_Homo sapiens	8392067
38	GPCR1206	MELANOCORTIN RECEPTOR_MC5_Homo sapiens	8185570
39	GPCR2502	TACHYKININ RECEPTOR_NK1_Homo sapiens	1370820
40	GPCR2504	TACHYKININ RECEPTOR_NK2_Homo sapiens-1	1370820
41	GPCR2509	TACHYKININ RECEPTOR_NK2_Homo sapiens-2	1370820
42	GPCR2513	TACHYKININ RECEPTOR_NK3_Homo sapiens	1370820
43	GPCR2381	P2Y RECEPTOR_P2Y11_Homo sapiens	9405388
44	GPCR2621	VASOACTIVE INTESTINAL PEPTIDE AND PITUITARY ADENYLATE CYCLASE ACTIVATING PEPTIDE RECEPTOR_PAC1_Homo sapiens	8396727
45	GPCR2615	PARATHYROID HORMONE RECEPTOR_PARATHYROID HORMONE/PARATHYROID HORMONE-RELATED PEPTIDE RECEPTOR_Homo sapiens	1658941
46	GPCR2610	PARATHYROID HORMONE RECEPTOR_PARATHYROID HORMONE RECEPTOR_Homo sapiens	7797535
47	GPCR1104	LYSOPHOSPHOLIPID RECEPTOR_S1P-like_Homo sapiens-5	12220620
48	GPCR1119	LYSOPHOSPHOLIPID RECEPTOR_S1P-like_Homo sapiens-1	12220620
49	GPCR1120	LYSOPHOSPHOLIPID RECEPTOR_S1P-like_Homo sapiens-8	12220620
50	GPCR1122	LYSOPHOSPHOLIPID RECEPTOR_S1P-like_Homo sapiens-6	12220620
51	GPCR1124	LYSOPHOSPHOLIPID RECEPTOR_S1P-like_Homo sapiens-7	12220620
52	GPCR1126	LYSOPHOSPHOLIPID RECEPTOR_S1P-like_Homo sapiens-2	12220620
53	GPCR1130	LYSOPHOSPHOLIPID RECEPTOR_S1P-like_Homo sapiens-3	12220620
54	GPCR1135	LYSOPHOSPHOLIPID RECEPTOR_S1P-like_Homo sapiens-9	12220620
55	GPCR1137	LYSOPHOSPHOLIPID RECEPTOR_S1P-like_Homo sapiens-4	12220620
56	GPCR1138	LYSOPHOSPHOLIPID RECEPTOR_S1P-like_Homo sapiens-10	12220620
57	GPCR2617	SECRETIN RECEPTOR_SCT-R_Homo sapiens	1646711
58	GPCR2526	TRACE AMINE RECEPTOR_TaR_Homo sapiens-1	11459929
59	GPCR2527	TRACE AMINE RECEPTOR_TaR_Homo sapiens-4	11459929
60	GPCR2529	TRACE AMINE RECEPTOR_TaR-1_Homo sapiens	11459929
61	GPCR2539	TRACE AMINE RECEPTOR_TaR-3_Homo sapiens	11459929
62	GPCR2541	TRACE AMINE RECEPTOR_TaR-4_Homo sapiens	11459929
63	GPCR2543	TRACE AMINE RECEPTOR_TaR-5_Homo sapiens	11459929
64	GPCR0886	GLYCOPROTEIN HORMONE RECEPTOR_TSH RECEPTOR_Homo sapiens-2	8552586
65	GPCR0887	GLYCOPROTEIN HORMONE RECEPTOR_TSH RECEPTOR_Homo sapiens-1	8552586
66	GPCR0889	GLYCOPROTEIN HORMONE RECEPTOR_TSH RECEPTOR_Homo sapiens-3	8552586
67	GPCR2567	VASOPRESSIN AND OXYTOCIN RECEPTOR_V2_Homo sapiens	1534150
68	GPCR2627	VASOACTIVE INTESTINAL PEPTIDE AND PITUITARY ADENYLATE CYCLASE ACTIVATING PEPTIDE RECEPTOR_VPAC1_Homo sapiens-1	1675791
69	GPCR2630	VASOACTIVE INTESTINAL PEPTIDE AND PITUITARY ADENYLATE CYCLASE ACTIVATING PEPTIDE RECEPTOR_VPAC1_Homo sapiens-2	1675791
70	GPCR2634	VASOACTIVE INTESTINAL PEPTIDE AND PITUITARY ADENYLATE CYCLASE ACTIVATING PEPTIDE RECEPTOR_VPAC2_Homo sapiens	7733904


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	University of Athens Faculty of Biology Dept. of Cell Biology and Biophysics	Biophysics & Bioinformatics Laboratory