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gpDB::G-protein View
Entry 1 of 1 :: GPR0240 ::
CLASS Galpha
FAMILY Gq/11
SUBFAMILY Galpha-q
TYPE Galpha-q

Cross References:
UniProt P21279 | Q6PFF5 EMBL M55412 | BC057583
InterPro IPR001019 | IPR000654 | IPR011025 PDB 2BCJ
PRODOM PD000281
PRINTS PR00318 | PR00442 PFAM PF00503

Details:
NAME Galpha-q-Mus musculus
DESCRIPTION Guanine nucleotide-binding protein G(q) subunit alpha (Guaninenucleotide-binding protein alpha-q).
SPECIES Mus musculus COMMON NAME Mouse NCBI Taxonomy 10090
POST TRANSLATION MODIFICATIONS null GENE Gnaq
SEQUENCE 
MACCLSEEAKEARRINDEIERQLRRDKRDARRELKLLLLGTGESGKSTFIKQMRIIHGSG
YSDEDKRGFTKLVYQNIFTAMQAMIRAMDTLKIPYKYEHNKAHAQLVREVDVEKVSAFEN
PYVDAIKSLWNDPGIQECYDRRREYQLSDSTKYYLNDLDRVADPSYLPTQQDVLRVRVPT
TGIIEYPFDLQSVIFRMVDVGGQRSERRKWIHCFENVTSIMFLVALSEYDQVLVESDNEN
RMEESKALFRTIITYPWFQNSSVILFLNKKDLLEEKIMYSHLVDYFPEYDGPQRDAQAAR
EFILKMFVDLNPDSDKIIYSHFTCATDTENIRFVFAAVKDTILQLNLKEYNLV
 FRAGMENT NO
FUNCTION Guanine nucleotide-binding proteins (G proteins) ares involved as modulators or transducers in various transmembranes signaling systems
Effectors:
1EFF0126Burton's tyrosine kinase-Mus musculus-1Stimulation (indirect stimulation of p38 MAPK)15251227 | 9305846 | 16182515
2EFF0127Burton's tyrosine kinase-Mus musculus-2Stimulation (indirect stimulation of p38 MAPK)15251227 | 9305846 | 16182515
3EFF0293Caveolin-1-Mus musculusGq Binds Caveolin to Concentrate in Caveolae16182515 | 11251080
4EFF0336EBP50/NHERF-1-Mus musculus-1Inhibits PLC-beta activation and blocks Gqa-induce Tph and CXCR4 receptor internalization16182515
5EFF0337EBP50/NHERF-1-Mus musculus-2Inhibits PLC-beta activation and blocks Gqa-induce Tph and CXCR4 receptor internalization16182515
6EFF0338EBP50/NHERF-1-Mus musculus-3Inhibits PLC-beta activation and blocks Gqa-induce Tph and CXCR4 receptor internalization16182515
7EFF0352GRK2-Mus musculus-1Inhibits PLC-beta activation and blocks Gqa-mediated GLUT4 translocation and glucose uptake in 3T3 adipocytes15251227 | 14654303 | 16182515
8EFF0353GRK2-Mus musculus-2Inhibits PLC-beta activation and blocks Gqa-mediated GLUT4 translocation and glucose uptake in 3T3 adipocytes15251227 | 14654303 | 16182515
9EFF0354GRK2-Mus musculus-3Inhibits PLC-beta activation and blocks Gqa-mediated GLUT4 translocation and glucose uptake in 3T3 adipocytes15251227 | 14654303 | 16182515
10EFF0355GRK2-Mus musculus-4Inhibits PLC-beta activation and blocks Gqa-mediated GLUT4 translocation and glucose uptake in 3T3 adipocytes15251227 | 14654303 | 16182515
11EFF0361GRK3-Mus musculus-1Stimulation15251227 | 14654303 | 16182515
12EFF0362GRK3-Mus musculus-2Stimulation15251227 | 14654303 | 16182515
13EFF0363GRK3-Mus musculus-3Stimulation15251227 | 14654303 | 16182515
14EFF0399Kir 3.1(GIRK1)-Mus musculus-1Inhibition12661754
15EFF0400Kir 3.1(GIRK1)-Mus musculus-2Inhibition12661754
16EFF0401Kir 3.1(GIRK1)-Mus musculus-3Inhibition12661754
17EFF0402Kir 3.1(GIRK1)-Mus musculus-4Inhibition12661754
18EFF0412Kir 3.2(GIRK2)-Mus musculus-1Inhibition12661754
19EFF0413Kir 3.2(GIRK2)-Mus musculus-2Inhibition12661754
20EFF0414Kir 3.2(GIRK2)-Mus musculus-3Inhibition12661754
21EFF0415Kir 3.2(GIRK2)-Mus musculus-4Inhibition12661754
22EFF0421Kir 3.3(GIRK3)-Mus musculus-1Inhibition12661754
23EFF0422Kir 3.3(GIRK3)-Mus musculus-2Inhibition12661754
24EFF0427Kir 3.4(GIRK4)-Mus musculus-1Inhibition12661754
25EFF0428Kir 3.4(GIRK4)-Mus musculus-2Inhibition12661754
26EFF0429Kir 3.4(GIRK4)-Mus musculus-3Inhibition12661754
27EFF0430Kir 3.4(GIRK4)-Mus musculus-4Inhibition12661754
28EFF0436LARG RhoGEF-Mus musculus-1Stimulation (indirect activation of Rho)15251227 | 12024019
29EFF0437LARG RhoGEF-Mus musculus-2Stimulation (indirect activation of Rho)15251227 | 12024019
30EFF0438LARG RhoGEF-Mus musculus-3Stimulation (indirect activation of Rho)15251227 | 12024019
31EFF0439LARG RhoGEF-Mus musculus-4Stimulation (indirect activation of Rho)15251227 | 12024019
32EFF0447PDZ RhoGEF-Mus musculus-1No data1525227 | 16182515
33EFF0448PDZ RhoGEF-Mus musculus-2No data1525227 | 16182515
34EFF0449PDZ RhoGEF-Mus musculus-3No data1525227 | 16182515
35EFF0450PDZ RhoGEF-Mus musculus-4No data1525227 | 16182515
36EFF0451PDZ RhoGEF-Mus musculus-5No data1525227 | 16182515
37EFF0523Phospholipase C beta-1-Mus musculus-1Stimulation of PLC-beta catalytic activity15251227 | 16182515 | 11015615
38EFF0524Phospholipase C beta-1-Mus musculus-2Stimulation of PLC-beta catalytic activity15251227 | 16182515 | 11015615
39EFF0525Phospholipase C beta-1-Mus musculus-3Stimulation of PLC-beta catalytic activity15251227 | 16182515 | 11015615
40EFF0526Phospholipase C beta-1-Mus musculus-4Stimulation of PLC-beta catalytic activity15251227 | 16182515 | 11015615
41EFF0527Phospholipase C beta-1-Mus musculus-5Stimulation of PLC-beta catalytic activity15251227 | 16182515 | 11015615
42EFF0532Phospholipase C beta-2-Mus musculus-1Stimulation of PLC-beta catalytic activity15251227 | 16182515 | 11015615
43EFF0533Phospholipase C beta-2-Mus musculus-2Stimulation of PLC-beta catalytic activity15251227 | 16182515 | 11015615
44EFF0535Phospholipase C beta-2-Mus musculus-3Stimulation of PLC-beta catalytic activity15251227 | 16182515 | 11015615
45EFF0537Phospholipase C beta-2-Mus musculus-4Stimulation of PLC-beta catalytic activity15251227 | 16182515 | 11015615
46EFF0543Phospholipase C beta-3-Mus musculus-1Stimulation of PLC-beta catalytic activity15251227 | 16182515 | 11015615
47EFF0544Phospholipase C beta-3-Mus musculus-2Stimulation of PLC-beta catalytic activity15251227 | 16182515 | 11015615
48EFF0545Phospholipase C beta-3-Mus musculus-3Stimulation of PLC-beta catalytic activity15251227 | 16182515 | 11015615
49EFF0546Phospholipase C beta-3-Mus musculus-4Stimulation of PLC-beta catalytic activity15251227 | 16182515 | 11015615
50EFF0547Phospholipase C beta-3-Mus musculus-5Stimulation of PLC-beta catalytic activity15251227 | 16182515 | 11015615
51EFF0548Phospholipase C beta-3-Mus musculus-6Stimulation of PLC-beta catalytic activity15251227 | 16182515 | 11015615
52EFF0549Phospholipase C beta-3-Mus musculus-7Stimulation of PLC-beta catalytic activity15251227 | 16182515 | 11015615
53EFF0550Phospholipase C beta-3-Mus musculus-8Stimulation of PLC-beta catalytic activity15251227 | 16182515 | 11015615
54EFF0551Phospholipase C beta-3-Mus musculus-9Stimulation of PLC-beta catalytic activity15251227 | 16182515 | 11015615
55EFF0564Phospholipase C beta-4-Mus musculus-1Stimulation of PLC-beta catalytic activity15251227 | 16182515 | 11015615
56EFF0565Phospholipase C beta-4-Mus musculus-2Stimulation of PLC-beta catalytic activity15251227 | 16182515 | 11015615
57EFF0566Phospholipase C beta-4-Mus musculus-3Stimulation of PLC-beta catalytic activity15251227 | 16182515 | 11015615
58EFF0567Phospholipase C beta-4-Mus musculus-4Stimulation of PLC-beta catalytic activity15251227 | 16182515 | 11015615
59EFF0568Phospholipase C beta-4-Mus musculus-5Stimulation of PLC-beta catalytic activity15251227 | 16182515 | 11015615
60EFF0573PI3K alpha-Mus musculusInhibition of PI3K kinase activity in vitro16182515
61EFF0579PI3K beta-Mus musculus-1Inhibition of PI3K kinase activity in vitro16182515
62EFF0580PI3K beta-Mus musculus-2Inhibition of PI3K kinase activity in vitro16182515
63EFF0581PI3K beta-Mus musculus-3Inhibition of PI3K kinase activity in vitro16182515
64EFF0582PI3K beta-Mus musculus-4Inhibition of PI3K kinase activity in vitro16182515
65EFF0583PI3K beta-Mus musculus-5Inhibition of PI3K kinase activity in vitro16182515
66EFF0587PI3K gamma-Mus musculus-1Inhibition of PI3K kinase activity in vitro16182515
67EFF0588PI3K gamma-Mus musculus-2Inhibition of PI3K kinase activity in vitro16182515
68EFF0589PI3K gamma-Mus musculus-3Inhibition of PI3K kinase activity in vitro16182515
69EFF0590PI3K gamma-Mus musculus-4Inhibition of PI3K kinase activity in vitro16182515
70EFF0591PI3K gamma-Mus musculus-5Inhibition of PI3K kinase activity in vitro16182515
71EFF0592PI3K gamma-Mus musculus-6Inhibition of PI3K kinase activity in vitro16182515
72EFF0593PI3K gamma-Mus musculus-7Inhibition of PI3K kinase activity in vitro16182515
73EFF0596Protein kinase D-Mus musculusStimulation10636921
74EFF0878TRP repeat protein-1-Mus musculus-1G16a co-expression enhances TPR1 interaction with Ras16182515 | 12748287
75EFF0880TRP repeat protein-1-Mus musculus-2G16a co-expression enhances TPR1 interaction with Ras16182515 | 12748287
76EFF1192Tubulin-Mus musculus-1Potentiates receptor-induced PLC-beta activation16182515
77EFF1193Tubulin-Mus musculus-10Potentiates receptor-induced PLC-beta activation16182515
78EFF1194Tubulin-Mus musculus-11Potentiates receptor-induced PLC-beta activation16182515
79EFF1195Tubulin-Mus musculus-12Potentiates receptor-induced PLC-beta activation16182515
80EFF1202Tubulin-Mus musculus-19Potentiates receptor-induced PLC-beta activation16182515
81EFF1203Tubulin-Mus musculus-2Potentiates receptor-induced PLC-beta activation16182515
82EFF1209Tubulin-Mus musculus-25Potentiates receptor-induced PLC-beta activation16182515
83EFF1214Tubulin-Mus musculus-3Potentiates receptor-induced PLC-beta activation16182515
84EFF1217Tubulin-Mus musculus-32Potentiates receptor-induced PLC-beta activation16182515
85EFF1218Tubulin-Mus musculus-33Potentiates receptor-induced PLC-beta activation16182515
86EFF1220Tubulin-Mus musculus-35Potentiates receptor-induced PLC-beta activation16182515
87EFF1221Tubulin-Mus musculus-34Potentiates receptor-induced PLC-beta activation16182515
88EFF1223Tubulin-Mus musculus-31Potentiates receptor-induced PLC-beta activation16182515
89EFF1225Tubulin-Mus musculus-4Potentiates receptor-induced PLC-beta activation16182515
90EFF1226Tubulin-Mus musculus-30Potentiates receptor-induced PLC-beta activation16182515
91EFF1227Tubulin-Mus musculus-29Potentiates receptor-induced PLC-beta activation16182515
92EFF1228Tubulin-Mus musculus-28Potentiates receptor-induced PLC-beta activation16182515
93EFF1230Tubulin-Mus musculus-27Potentiates receptor-induced PLC-beta activation16182515
94EFF1231Tubulin-Mus musculus-26Potentiates receptor-induced PLC-beta activation16182515
95EFF1232Tubulin-Mus musculus-24Potentiates receptor-induced PLC-beta activation16182515
96EFF1233Tubulin-Mus musculus-23Potentiates receptor-induced PLC-beta activation16182515
97EFF1235Tubulin-Mus musculus-22Potentiates receptor-induced PLC-beta activation16182515
98EFF1236Tubulin-Mus musculus-5Potentiates receptor-induced PLC-beta activation16182515
99EFF1237Tubulin-Mus musculus-21Potentiates receptor-induced PLC-beta activation16182515
100EFF1238Tubulin-Mus musculus-20Potentiates receptor-induced PLC-beta activation16182515
101EFF1239Tubulin-Mus musculus-18Potentiates receptor-induced PLC-beta activation16182515
102EFF1240Tubulin-Mus musculus-17Potentiates receptor-induced PLC-beta activation16182515
103EFF1241Tubulin-Mus musculus-16Potentiates receptor-induced PLC-beta activation16182515
104EFF1242Tubulin-Mus musculus-15Potentiates receptor-induced PLC-beta activation16182515
105EFF1243Tubulin-Mus musculus-14Potentiates receptor-induced PLC-beta activation16182515
106EFF1244Tubulin-Mus musculus-13Potentiates receptor-induced PLC-beta activation16182515
107EFF1245Tubulin-Mus musculus-6Potentiates receptor-induced PLC-beta activation16182515
108EFF1246Tubulin-Mus musculus-7Potentiates receptor-induced PLC-beta activation16182515
109EFF1247Tubulin-Mus musculus-8Potentiates receptor-induced PLC-beta activation16182515
110EFF1248Tubulin-Mus musculus-9Potentiates receptor-induced PLC-beta activation16182515

Coupling with GPCRs:
1GPCR00665-HYDROXYTRYPTAMINE RECEPTOR_5-HT-2A_Mus musculus1765383
2GPCR00835-HYDROXYTRYPTAMINE RECEPTOR_5-HT-2B_Mus musculus-18786115
3GPCR00855-HYDROXYTRYPTAMINE RECEPTOR_5-HT-2C_Mus musculus1302605
4GPCR0208ADRENOCEPTOR (A1-ADRENOCEPTOR)_A1A(Adrenoceptor)_Mus musculus8396931
5GPCR0220ADRENOCEPTOR (A1-ADRENOCEPTOR)_A1B(Adrenoceptor)_Mus musculus-11662393
6GPCR0221ADRENOCEPTOR (A1-ADRENOCEPTOR)_A1B(Adrenoceptor)_Mus musculus-21662393
7GPCR0229ADRENOCEPTOR (A1-ADRENOCEPTOR)_A1D(Adrenoceptor)_Mus musculus1656955
8GPCR0233ADRENOCEPTOR (A2-ADRENOCEPTOR)_A2A(Adrenoceptor)_Mus musculus8662784
9GPCR0409ANGIOTENSIN RECEPTOR_AT1_Mus musculus-28865167
10GPCR0421ANGIOTENSIN RECEPTOR_AT1_Mus musculus-18865167
11GPCR0461BRADYKININ RECEPTOR_B1_Mus musculus1657928
12GPCR0474BRADYKININ RECEPTOR_B2_Mus musculus1657928
13GPCR0448BOMBESIN RECEPTOR_BB1_Mus musculus8531502
14GPCR0452BOMBESIN RECEPTOR_BB2_Mus musculus8531502
15GPCR0455BOMBESIN RECEPTOR_BB3_Mus musculus8383682
16GPCR0993LEUKOTRIENE RECEPTOR_BLT_Mus musculus9177352
17GPCR2575CALCITONIN, AMYLIN, CGRP, AND ADRENOMEDULIN RECEPTOR_CALCITONIN_Mus musculus8732687
18GPCR2636EXTRACELLULAR CALCIUM-SENSING RECEPTOR_CASR_Mus musculus8255296
19GPCR0733CHOLECYSTOKININ AND GASTRIN RECEPTOR_CCK1_Mus musculus8503909
20GPCR0743CHOLECYSTOKININ AND GASTRIN RECEPTOR_CCK2_Mus musculus1280419
21GPCR2581CALCITONIN, AMYLIN, CGRP, AND ADRENOMEDULIN RECEPTOR_CGRP_Mus musculus2536720
22GPCR1000LEUKOTRIENE RECEPTOR_CYSLT-1_Mus musculus10391245
23GPCR1001LEUKOTRIENE RECEPTOR_CYSLT-2_Mus musculus10913337
24GPCR2420PROSTANOID RECEPTOR_EP1_Mus musculus8253813
25GPCR2430PROSTANOID RECEPTOR_EP3_Mus musculus11095474
26GPCR0815ENDOTHELIN RECEPTOR_ET-A_Mus musculus1849646
27GPCR0823ENDOTHELIN RECEPTOR_ET-B_Mus musculus1848367
28GPCR2439PROSTANOID RECEPTOR_FP_Mus musculus8300593
29GPCR2728FRIZZLED_Frizzled-1_Mus musculus11563835
30GPCR2739FRIZZLED_Frizzled-2_Mus musculus11563835
31GPCR0837GALANIN RECEPTOR_GAL2_Mus musculus9685625
32GPCR0905GONADOTROPIN-RELEASING HORMONE RECEPTOR_GNRH1_Mus musculus1333190
33GPCR2604GROWTH HORMONE RELEASING PEPTIDES RECEPTOR_Growth hormone secretagogue receptor type 1(Ghrelin receptor)_Mus musculus8688086
34GPCR0965HISTAMINE RECEPTOR_H1_Mus musculus1722337
35GPCR1009LYSOPHOSPHOLIPID RECEPTOR_LPA1_Mus musculus9600933
36GPCR1011LYSOPHOSPHOLIPID RECEPTOR_LPA2_Mus musculus9525886
37GPCR1016LYSOPHOSPHOLIPID RECEPTOR_LPA3_Mus musculus12215548
38GPCR0877GLYCOPROTEIN HORMONE RECEPTOR_LSH RECEPTOR_Mus musculus1516719
39GPCR0118ACETYLCHOLINE RECEPTOR (MUSCARINIC)_M1_Mus musculus3037705
40GPCR0136ACETYLCHOLINE RECEPTOR (MUSCARINIC)_M3_Mus musculus11242080
41GPCR0158ACETYLCHOLINE RECEPTOR (MUSCARINIC)_M5_Mus musculus3037705
42GPCR2796MELANIN-CONCENTRATING HORMONE RECEPTOR_MCHR1_Mus musculus10559938
43GPCR2647GLUTAMATE RECEPTOR (METABOTROPIC)_MGLU1_Mus musculus9076744
44GPCR1238NEUROMEDIN RECEPTOR_Neuromedin U 2_Mus musculus10894543
45GPCR2500TACHYKININ RECEPTOR_NK1_Mus musculus1370820
46GPCR2508TACHYKININ RECEPTOR_NK2_Mus musculus1370820
47GPCR2512TACHYKININ RECEPTOR_NK3_Mus musculus1370820
48GPCR1275NEUROTENSIN RECEPTOR_NTS1_Mus musculus8381365
49GPCR1277NEUROTENSIN RECEPTOR_NTS2_Mus musculus8647296
50GPCR2363OREXIN RECEPTOR_Orexin 1_Mus musculus9491897
51GPCR2368OREXIN RECEPTOR_Orexin 2_Mus musculus9491897
52GPCR2552VASOPRESSIN AND OXYTOCIN RECEPTOR_OT_Mus musculus1313946
53GPCR2373P2Y RECEPTOR_P2Y1_Mus musculus8159738
54GPCR2393P2Y RECEPTOR_P2Y2_Mus musculus8159738
55GPCR2401P2Y RECEPTOR_P2Y4_Mus musculus9396022
56GPCR2619VASOACTIVE INTESTINAL PEPTIDE AND PITUITARY ADENYLATE CYCLASE ACTIVATING PEPTIDE RECEPTOR_PAC1_Mus musculus8396727
57GPCR2453PROTEASE-ACTIVATED RECEPTOR_PAR1_Mus musculus10644723
58GPCR2459PROTEASE-ACTIVATED RECEPTOR_PAR2_Mus musculus15082510
59GPCR2462PROTEASE-ACTIVATED RECEPTOR_PAR3_Mus musculus15082510
60GPCR2466PROTEASE-ACTIVATED RECEPTOR_PAR4_Mus musculus15082510
61GPCR2413PLATELET ACTIVATING FACTOR (PAF) RECEPTOR_PLATELET ACTIVATING FACTOR (PAF) RECEPTOR_Mus musculus7876256
62GPCR1087LYSOPHOSPHOLIPID RECEPTOR_S1P2_Mus musculus10617617
63GPCR1096LYSOPHOSPHOLIPID RECEPTOR_S1P3_Mus musculus9409733
64GPCR1099LYSOPHOSPHOLIPID RECEPTOR_S1P4_Mus musculus10679247
65GPCR2452PROSTANOID RECEPTOR_TP_Mus musculus8300593
66GPCR2525THYROTROPIN-RELEASING HORMONE RECEPTOR_TRH1_Mus musculus2175902
67GPCR0897GLYCOPROTEIN HORMONE RECEPTOR_TSH RECEPTOR_Mus musculus-18552586
68GPCR2549UROTENSIN RECEPTOR_UROTENSIN II RECEPTOR_Mus musculus10499587
69GPCR2560VASOPRESSIN AND OXYTOCIN RECEPTOR_V1A_Mus musculus1560825
70GPCR2563VASOPRESSIN AND OXYTOCIN RECEPTOR_V1B_Mus musculus11091117
71GPCR1245NEUROPEPTIDE Y RECEPTOR_Y1_Mus musculus1321422



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