gpDB: a database of G-proteins and their interaction with GPCRs
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gpDB::GPCR View
Entry 1 of 1 :: GPCR2560 ::
CLASS CLASS A (RHODOPSIN LIKE)
FAMILY VASOPRESSIN AND OXYTOCIN RECEPTOR
SUBFAMILY V1A

Cross References:
UniProt Q62463 | Q62464 | Q9QYH2 EMBL D49729 | D49730 | AB030013 | BC024149
InterPro IPR015076 | IPR000276 | IPR001817 | IPR001224 GPCRDB v1ar_mouse
GENEID 54140
PRINTS PR00237 | PR00896 | PR00752 PFAM PF00001 | PF08983

Details:
NAME VASOPRESSIN AND OXYTOCIN RECEPTOR_V1A_Mus musculus
DESCRIPTION Vasopressin V1a receptor (V1aR) (Vascular/hepatic-type argininevasopressin receptor) (Antidiuretic hormone receptor 1a) (AVPR V1a).
SPECIES Mus musculus COMMON NAME Mouse NCBI Taxonomy 10090
GENE Avpr1a
SEQUENCE
MSFPRGSHDLPAGNSSPWWPLTTEGANSSREAAGLGEGGSPPGDVRNEELAKLEVTVLAV
IFVVAVLGNSSVLLALHRTPRKTSRMHLFIRHLSLADLAVAFFQVLPQLCWDITYRFRGP
DWLCRVVKHLQVFAMFASSYMLVVMTADRYIAVCHPLKTLQQPARRSRLMIAASWGLSFV
LSIPQYFIFSVIEFEVNNGTKAQDCWATFIPPWGTRAYVTWMTSGVFVVPVIILGTCYGF
ICYHIWRNVRGKTASRQSKGGKGSGEAAGPFHKGLLVTPCVSSVKSISRAKIRTVKMTFV
IVSAYILCWTPFFIVQMWSVWDTNFVWTDSENPSTTITALLASLNSCCNPWIYMFFSGHL
LQDCVQSFPCCQSIAQKFAKDDSDSMSRRQTSYSNNRSPTNSTGTWKDSPKSSKSIRFIP
VST
FRAGMENT NO

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Dimerization:
HOMODIMER INFORMATION There is experimental evidence for homo-dimerization METHOD Bioluminescence Resonance Energy Transfer (BRET) REFERENCES 12554793
HETERODIMER INFORMATION Forms functional heterodimers with V2 Receptors METHOD Bioluminescence Resonance Energy Transfer (BRET) REFERENCES 12554793
HETERODIMER INFORMATION Forms functional heterodimers with OT Receptors METHOD Bioluminescence Resonance Energy Transfer (BRET) REFERENCES 12554793

Coupling with G-proteins:
Family:G12/13 REFERENCES:10364236
1GPR0035Galpha-12-Mus musculus
2GPR0038Galpha-13-Mus musculus-2
3GPR0323Galpha-13-Mus musculus-3
4GPR0380Galpha-13-Mus musculus-1
Family:Gq/11 REFERENCES:1560825
5GPR0031Galpha-11-Mus musculus-2
6GPR0240Galpha-q-Mus musculus
7GPR0360Galpha-11-Mus musculus-1


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athina University of Athens
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Biophysics
& Bioinformatics
Laboratory