gpDB: a database of G-proteins and their interaction with GPCRs
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gpDB::Effector View
Entry 1 of 1 :: EFF0582 ::
FAMILY PI3/PI4 kinases
SUBFAMILY Class Ia PI3Ks
TYPE PI3K beta

Cross References:
UniProt Q8BTI9 EMBL AK090116
InterPro IPR000403 | IPR002420 | IPR003113 | IPR000341 | IPR001263 | IPR015433
GENEID 74769
PFAM PF00454 | PF00792 | PF02192 | PF00794 | PF00613

Details:
NAME PI3K beta-Mus musculus-4
DESCRIPTION Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit betaisoform (EC 2.7.1.153) (PI3-kinase p110 subunit beta) (PtdIns-3-kinasep110) (PI3K) (PI3Kbeta).
SPECIES Mus musculus COMMON NAME Mouse NCBI Taxonomy 10090
GENE Pik3cb
SEQUENCE
MPPAMADNLDIWAVDSQIASDGAISVDFLLPTGIYIQLEVPREATISYIKQMLWKQVHNY
PMFNLLMDIDSYMFACVNQTAVYEELEDETRRLCDVRPFLPVLKLVTRSCDPAEKLDSKI
GVRIGKGLHEFDALKDPEVNEFRRKMRKFSEAKIQSLVGLSWIDWLKHTYPPEHEPSVLE
NLEDKLYGGKLVVAVHFENSQDVFSFQVSPNLNPIKINELAIQKRLTIRGKEDEASPCDY
VLQVSGRVEYVFGDH
FRAGMENT NO
FUNCTION Phosphorylates PtdIns, PtdIns4P and PtdIns(4,5)P2 with as preference for PtdIns(4,5)P2 (By similarity)
Interacting with G-proteins:
Family:Gq/11 REFERENCES:16182515
1GPR0240Galpha-q-Mus musculus
Family:Gbeta REFERENCES:9305878 | 12502714
2GPR0148Gbeta-1-Mus musculus
3GPR0156Gbeta-2-Mus musculus
4GPR0161Gbeta-3-Mus musculus
5GPR0165Gbeta-4-Mus musculus
6GPR0168Gbeta-5-Mus musculus-2
7GPR0291unclassified_Gbeta-Mus musculus-1
8GPR0318unclassified_Gbeta-Mus musculus-2
9GPR0376Gbeta-5-Mus musculus-3
10GPR0377Gbeta-5-Mus musculus-1
Family:Ggamma REFERENCES:9305878 | 12502714
11GPR0178Ggamma-t1-Mus musculus
12GPR0181Ggamma-2-Mus musculus
13GPR0184Ggamma-3-Mus musculus
14GPR0186Ggamma-4-Mus musculus
15GPR0189Ggamma-5-Mus musculus
16GPR0193Ggamma-7-Mus musculus
17GPR0196Ggamma-8-Mus musculus-2
18GPR0200Ggamma-11-Mus musculus
19GPR0204Ggamma-12-Mus musculus
20GPR0206Ggamma-13-Mus musculus
21GPR0211Ggamma-8-Mus musculus-1
22GPR0349Ggamma-1-Mus musculus
23GPR0379Ggamma-10-Mus musculus


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athina University of Athens
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Dept. of Cell Biology and Biophysics
Biophysics
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Laboratory