gpDB: a database of G-proteins and their interaction with GPCRs
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gpDB::Effector View
Entry 1 of 1 :: EFF0362 ::
FAMILY Ser Thr protein kinases
SUBFAMILY G protein coupled receptor kinases
TYPE GRK3

Cross References:
UniProt Q3UYH7 EMBL AK134672
InterPro IPR015743 | IPR000239 | IPR001849 | IPR011993 | IPR000961 | IPR000719 | IPR000342 | IPR002290
PRODOM PD000001
PRINTS PR00717 PFAM PF00169 | PF00069 | PF00615

Details:
NAME GRK3-Mus musculus-2
DESCRIPTION Beta-adrenergic receptor kinase 2 (EC 2.7.11.15) (Beta-ARK-2).
SPECIES Mus musculus COMMON NAME Mouse NCBI Taxonomy 10090
GENE Adrbk2
SEQUENCE 
MADLEAVLADVSYLMAMEKSKTAPAARASKKVVLPEPSIRSVMQRYLAERNEITFDKIFN
QKIGFLLFKDFCLNEIGEAVPQVKFYEEIKEYEKLDNEEDRLRRSRQMYDAYIMRELLSS
THQFSKQAVEHVQSHLSKKQVTATLFQPYIEEICESLRGDIFQKFMESDKFTRFCQWKNV
ELNIHLSMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRVKMKQGETLALNER
IMLSLVSTGDCPFIV
 FRAGMENT NO
FUNCTION Specifically phosphorylates the agonist-occupied form ofs the beta-adrenergic and closely related receptors
Interacting with G-proteins:
Family:Gq/11 REFERENCES:15251227 | 14654303 | 16182515
1GPR0031Galpha-11-Mus musculus-2
2GPR0360Galpha-11-Mus musculus-1
3GPR0240Galpha-q-Mus musculus
Family:Gbeta REFERENCES:15251227 | 14654303
4GPR0148Gbeta-1-Mus musculus
5GPR0156Gbeta-2-Mus musculus
6GPR0161Gbeta-3-Mus musculus
7GPR0165Gbeta-4-Mus musculus
8GPR0168Gbeta-5-Mus musculus-2
9GPR0291unclassified_Gbeta-Mus musculus-1
10GPR0318unclassified_Gbeta-Mus musculus-2
11GPR0376Gbeta-5-Mus musculus-3
12GPR0377Gbeta-5-Mus musculus-1
Family:Ggamma REFERENCES:15251227 | 14654303
13GPR0178Ggamma-t1-Mus musculus
14GPR0181Ggamma-2-Mus musculus
15GPR0184Ggamma-3-Mus musculus
16GPR0186Ggamma-4-Mus musculus
17GPR0189Ggamma-5-Mus musculus
18GPR0193Ggamma-7-Mus musculus
19GPR0196Ggamma-8-Mus musculus-2
20GPR0200Ggamma-11-Mus musculus
21GPR0204Ggamma-12-Mus musculus
22GPR0206Ggamma-13-Mus musculus
23GPR0211Ggamma-8-Mus musculus-1
24GPR0349Ggamma-1-Mus musculus
25GPR0379Ggamma-10-Mus musculus

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