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gpDB::G-protein View
Entry 1 of 1 :: GPR0147 ::
CLASS Gbeta
FAMILY Gbeta
SUBFAMILY Gbeta
TYPE Gbeta-1

Cross References:
UniProt P62873 | P04697 | P04901 EMBL X04526 | AF501882 | BT007305 | CR456784 | BC004186 | BC005888 | BC008991 | M36430
InterPro IPR001632 | IPR015943 | IPR001680
PRODOM PD000018
GENEID 2782 MIM 139380
PRINTS PR00319 | PR00320 PFAM PF00400

Details:
NAME Gbeta-1-Homo sapiens
DESCRIPTION Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1(Transducin beta chain 1).
SPECIES Homo sapiens COMMON NAME Human NCBI Taxonomy 9606
POST TRANSLATION MODIFICATIONS null GENE GNB1
SEQUENCE 
MSELDQLRQEAEQLKNQIRDARKACADATLSQITNNIDPVGRIQMRTRRTLRGHLAKIYA
MHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNI
CSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTTCALWDIETGQQTTTF
TGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNA
FATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDAL
KADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN
 FRAGMENT NO
FUNCTION Guanine nucleotide-binding proteins (G proteins) ares involved as a modulator or transducer in various transmembranes signaling systems
Effectors:
1EFF0002Adenylate cyclase-1-Homo sapiens-1Inhibition15251227 | 15922020 | 14993377 | 11376933 | 10449730
2EFF0003Adenylate cyclase-1-Homo sapiens-2Inhibition15251227 | 15922020 | 14993377 | 11376933 | 10449730
3EFF0006Adenylate cyclase-2-Homo sapiens-1Stimulation15251227 | 15922020 | 14993377 | 11376933
4EFF0007Adenylate cyclase-2-Homo sapiens-2Stimulation15251227 | 15922020 | 14993377 | 11376933
5EFF0020Adenylate cyclase-4-Homo sapiens-1Stimulation15251227 | 15922020 | 14993377 | 11376933
6EFF0021Adenylate cyclase-4-Homo sapiens-2Stimulation15251227 | 15922020 | 14993377 | 11376933
7EFF0030Adenylate cyclase-5-Homo sapiensInhibition15251227 | 15922020 | 14993377 | 11376933
8EFF0039Adenylate cyclase-6-Homo sapiensInhibition15251227 | 15922020 | 14993377 | 11376933
9EFF0045Adenylate cyclase-7-Homo sapiensStimulation15251227 | 15922020 | 14993377 | 11376933
10EFF0067ATP-sensitive inward rectifier potassium channel-1-Homo sapiensStimulation15251227 | 10990455
11EFF0071ATP-sensitive inward rectifier potassium channel-10-Homo sapiens-1Stimulation15251227 | 10990455
12EFF0072ATP-sensitive inward rectifier potassium channel-10-Homo sapiens-2Stimulation15251227 | 10990455
13EFF0073ATP-sensitive inward rectifier potassium channel-10-Homo sapiens-3Stimulation15251227 | 10990455
14EFF0083ATP-sensitive inward rectifier potassium channel-11-Homo sapiensStimulation15251227 | 10990455
15EFF0089ATP-sensitive inward rectifier potassium channel-12-Homo sapiensStimulation15251227 | 10990455
16EFF0096ATP-sensitive inward rectifier potassium channel-14-Homo sapiensStimulation15251227 | 10990455
17EFF0101ATP-sensitive inward rectifier potassium channel-15-Homo sapiensStimulation15251227 | 10990455
18EFF0109ATP-sensitive inward rectifier potassium channel-8-Homo sapiensStimulation15251227 | 10990455
19EFF0117Burton's tyrosine kinase-Homo sapiens-1Stimulation15251227 | 11698416
20EFF0118Burton's tyrosine kinase-Homo sapiens-2Stimulation15251227 | 11698416
21EFF0120Burton's tyrosine kinase-Homo sapiens-3Stimulation15251227 | 11698416
22EFF0121Burton's tyrosine kinase-Homo sapiens-4Stimulation15251227 | 11698416
23EFF0122Burton's tyrosine kinase-Homo sapiens-5Stimulation15251227 | 11698416
24EFF0123Burton's tyrosine kinase-Homo sapiens-6Stimulation15251227 | 11698416
25EFF0124Burton's tyrosine kinase-Homo sapiens-7Stimulation15251227 | 11698416
26EFF0125Burton's tyrosine kinase-Homo sapiens-8Stimulation15251227 | 11698416
27EFF0193Calmodulin-Homo sapiens-1Inhibition of calmodulin kinase15251227
28EFF0194Calmodulin-Homo sapiens-2Inhibition of calmodulin kinase15251227
29EFF0195Calmodulin-Homo sapiens-3Inhibition of calmodulin kinase15251227
30EFF0197Calmodulin-Homo sapiens-5Inhibition of calmodulin kinase15251227
31EFF0198Calmodulin-Homo sapiens-6Inhibition of calmodulin kinase15251227
32EFF0200Calmodulin-Homo sapiens-8Inhibition of calmodulin kinase15251227
33EFF0201Calmodulin-Homo sapiens-4Inhibition of calmodulin kinase15251227
34EFF0302Dynamin-1-Homo sapiens-1Increased GTPase activity15251227 | 14671004
35EFF0303Dynamin-1-Homo sapiens-2Increased GTPase activity15251227 | 14671004
36EFF0304Dynamin-1-Homo sapiens-3Increased GTPase activity15251227 | 14671004
37EFF0305Dynamin-1-Homo sapiens-4Increased GTPase activity15251227 | 14671004
38EFF0306Dynamin-1-Homo sapiens-5Increased GTPase activity15251227 | 14671004
39EFF0307Dynamin-1-Homo sapiens-6Increased GTPase activity15251227 | 14671004
40EFF0308Dynamin-1-Homo sapiens-7Increased GTPase activity15251227 | 14671004
41EFF0350GRK2-Homo sapiensRecruitment to plasma membrane15251227 | 14654303
42EFF0359GRK3-Homo sapiens-1Recruitment to plasma membrane15251227 | 14654303
43EFF0360GRK3-Homo sapiens-2Recruitment to plasma membrane15251227 | 14654303
44EFF0389Kinase suppressor of Ras(KSR)-Homo sapiensSequestration of Gbeta/gamma15251227
45EFF0397Kir 3.1(GIRK1)-Homo sapiens-1Stimulation by beta1-4-containing dimers and inhibition by beta5-containing dimers15251227 | 10944236 | 12661754
46EFF0398Kir 3.1(GIRK1)-Homo sapiens-2Stimulation by beta1-4-containing dimers and inhibition by beta5-containing dimers15251227 | 10944236 | 12661754
47EFF0410Kir 3.2(GIRK2)-Homo sapiensStimulation by beta1-4-containing dimers and inhibition by beta5-containing dimers15251227 | 10944236 | 12661754
48EFF0420Kir 3.3(GIRK3)-Homo sapiensStimulation by beta1-4-containing dimers and inhibition by beta5-containing dimers14963032 | 11779482 | 12661754
49EFF0425Kir 3.4(GIRK4)-Homo sapiens-1Stimulation by beta1-4-containing dimers and inhibition by beta5-containing dimers15251227 | 10944236 | 12661754
50EFF0426Kir 3.4(GIRK4)-Homo sapiens-2Stimulation by beta1-4-containing dimers and inhibition by beta5-containing dimers15251227 | 10944236 | 12661754
51EFF0517Phospholipase C beta-1-Homo sapiens-1Stimulation15251227 | 11015615 | 8383116
52EFF0521Phospholipase C beta-1-Homo sapiens-2Stimulation15251227 | 11015615 | 8383116
53EFF0522Phospholipase C beta-1-Homo sapiens-3Stimulation15251227 | 11015615 | 8383116
54EFF0530Phospholipase C beta-2-Homo sapiens-1Stimulation15251227 | 11015615 | 8383116
55EFF0531Phospholipase C beta-2-Homo sapiens-2Stimulation15251227 | 11015615 | 8383116
56EFF0541Phospholipase C beta-3-Homo sapiens-1Stimulation15251227 | 11015615 | 8383116
57EFF0542Phospholipase C beta-3-Homo sapiens-2Stimulation15251227 | 11015615 | 8383116
58EFF0572PI3K alpha-Homo sapiensPropable Inhibition16182515
59EFF0577PI3K beta-Homo sapiens-1Activation9305878 | 12502714
60EFF0578PI3K beta-Homo sapiens-2Activation9305878 | 12502714
61EFF0586PI3K gamma-Homo sapiensActivation12502714
62EFF0595Protein kinase D-Homo sapiensStimulation15251227
63EFF0641Rac-Homo sapiens-1Stimulation,Recruitment to plasma membrane11099498 | 15251227
64EFF0642Rac-Homo sapiens-2Stimulation,Recruitment to plasma membrane11099498 | 15251227
65EFF0643Rac-Homo sapiens-3Stimulation,Recruitment to plasma membrane11099498 | 15251227
66EFF0681Raf1 protein kinase-Homo sapiens-1Sequestration of Gβγ15251227
67EFF0682Raf1 protein kinase-Homo sapiens-2Sequestration of Gβγ15251227
68EFF0696Ras specific nucleotide exchange factor CDC25-Homo sapiensStimulation (indirect activation of ras)15251227 | 8717044
69EFF0736Rho-Homo sapiens-1Recruitment to plasma membrane15251227
70EFF0737Rho-Homo sapiens-10Recruitment to plasma membrane15251227
71EFF0738Rho-Homo sapiens-11Recruitment to plasma membrane15251227
72EFF0739Rho-Homo sapiens-12Recruitment to plasma membrane15251227
73EFF0740Rho-Homo sapiens-13Recruitment to plasma membrane15251227
74EFF0741Rho-Homo sapiens-14Recruitment to plasma membrane15251227
75EFF0742Rho-Homo sapiens-15Recruitment to plasma membrane15251227
76EFF0743Rho-Homo sapiens-16Recruitment to plasma membrane15251227
77EFF0745Rho-Homo sapiens-18Recruitment to plasma membrane15251227
78EFF0746Rho-Homo sapiens-19Recruitment to plasma membrane15251227
79EFF0747Rho-Homo sapiens-2Recruitment to plasma membrane15251227
80EFF0748Rho-Homo sapiens-20Recruitment to plasma membrane15251227
81EFF0749Rho-Homo sapiens-17Recruitment to plasma membrane15251227
82EFF0750Rho-Homo sapiens-3Recruitment to plasma membrane15251227
83EFF0751Rho-Homo sapiens-4Recruitment to plasma membrane15251227
84EFF0752Rho-Homo sapiens-5Recruitment to plasma membrane15251227
85EFF0753Rho-Homo sapiens-6Recruitment to plasma membrane15251227
86EFF0754Rho-Homo sapiens-7Recruitment to plasma membrane15251227
87EFF0755Rho-Homo sapiens-8Recruitment to plasma membrane15251227
88EFF0756Rho-Homo sapiens-9Recruitment to plasma membrane15251227
89EFF0819SHC transforming protein-1-Homo sapiens-1Stimulation(indirect activation of MAPK)15251227 | 14671004 | 7568118
90EFF0820SHC transforming protein-1-Homo sapiens-10Stimulation(indirect activation of MAPK)15251227 | 14671004 | 7568118
91EFF0821SHC transforming protein-1-Homo sapiens-11Stimulation(indirect activation of MAPK)15251227 | 14671004 | 7568118
92EFF0822SHC transforming protein-1-Homo sapiens-2Stimulation(indirect activation of MAPK)15251227 | 14671004 | 7568118
93EFF0823SHC transforming protein-1-Homo sapiens-3Stimulation(indirect activation of MAPK)15251227 | 14671004 | 7568118
94EFF0824SHC transforming protein-1-Homo sapiens-4Stimulation(indirect activation of MAPK)15251227 | 14671004 | 7568118
95EFF0825SHC transforming protein-1-Homo sapiens-5Stimulation(indirect activation of MAPK)15251227 | 14671004 | 7568118
96EFF0826SHC transforming protein-1-Homo sapiens-6Stimulation(indirect activation of MAPK)15251227 | 14671004 | 7568118
97EFF0827SHC transforming protein-1-Homo sapiens-7Stimulation(indirect activation of MAPK)15251227 | 14671004 | 7568118
98EFF0828SHC transforming protein-1-Homo sapiens-8Stimulation(indirect activation of MAPK)15251227 | 14671004 | 7568118
99EFF0829SHC transforming protein-1-Homo sapiens-9Stimulation(indirect activation of MAPK)15251227 | 14671004 | 7568118
100EFF0835SHC transforming protein-2-Homo sapiensStimulation(indirect activation of MAPK)15251227 | 14671004 | 7568118
101EFF0838SHC transforming protein-3-Homo sapiens-1Stimulation(indirect activation of MAPK)15251227 | 14671004 | 7568118
102EFF0839SHC transforming protein-3-Homo sapiens-2Stimulation(indirect activation of MAPK)15251227 | 14671004 | 7568118
103EFF0840SHC transforming protein-3-Homo sapiens-3Stimulation(indirect activation of MAPK)15251227 | 14671004 | 7568118
104EFF0884Tsk tyrosine kinase-Homo sapiensStimulation15251227 | 14671004
105EFF1126Tubulin-Homo sapiens-1Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
106EFF1127Tubulin-Homo sapiens-10Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
107EFF1128Tubulin-Homo sapiens-11Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
108EFF1129Tubulin-Homo sapiens-12Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
109EFF1130Tubulin-Homo sapiens-13Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
110EFF1131Tubulin-Homo sapiens-14Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
111EFF1132Tubulin-Homo sapiens-15Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
112EFF1133Tubulin-Homo sapiens-16Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
113EFF1134Tubulin-Homo sapiens-17Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
114EFF1135Tubulin-Homo sapiens-18Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
115EFF1136Tubulin-Homo sapiens-19Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
116EFF1137Tubulin-Homo sapiens-2Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
117EFF1138Tubulin-Homo sapiens-20Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
118EFF1139Tubulin-Homo sapiens-21Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
119EFF1140Tubulin-Homo sapiens-22Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
120EFF1141Tubulin-Homo sapiens-23Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
121EFF1143Tubulin-Homo sapiens-25Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
122EFF1144Tubulin-Homo sapiens-26Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
123EFF1145Tubulin-Homo sapiens-27Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
124EFF1146Tubulin-Homo sapiens-28Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
125EFF1148Tubulin-Homo sapiens-3Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
126EFF1149Tubulin-Homo sapiens-30Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
127EFF1150Tubulin-Homo sapiens-31Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
128EFF1151Tubulin-Homo sapiens-32Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
129EFF1152Tubulin-Homo sapiens-33Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
130EFF1153Tubulin-Homo sapiens-34Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
131EFF1154Tubulin-Homo sapiens-35Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
132EFF1156Tubulin-Homo sapiens-37Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
133EFF1157Tubulin-Homo sapiens-38Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
134EFF1158Tubulin-Homo sapiens-39Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
135EFF1159Tubulin-Homo sapiens-4Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
136EFF1160Tubulin-Homo sapiens-40Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
137EFF1162Tubulin-Homo sapiens-42Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
138EFF1163Tubulin-Homo sapiens-43Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
139EFF1164Tubulin-Homo sapiens-44Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
140EFF1165Tubulin-Homo sapiens-45Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
141EFF1166Tubulin-Homo sapiens-46Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
142EFF1167Tubulin-Homo sapiens-47Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
143EFF1168Tubulin-Homo sapiens-48Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
144EFF1169Tubulin-Homo sapiens-49Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
145EFF1170Tubulin-Homo sapiens-5Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
146EFF1171Tubulin-Homo sapiens-50Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
147EFF1173Tubulin-Homo sapiens-52Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
148EFF1174Tubulin-Homo sapiens-51Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
149EFF1175Tubulin-Homo sapiens-41Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
150EFF1176Tubulin-Homo sapiens-36Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
151EFF1177Tubulin-Homo sapiens-29Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
152EFF1178Tubulin-Homo sapiens-24Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
153EFF1179Tubulin-Homo sapiens-6Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
154EFF1180Tubulin-Homo sapiens-7Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
155EFF1181Tubulin-Homo sapiens-8Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
156EFF1182Tubulin-Homo sapiens-9Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
157EFF1443Voltage dependent N type calcium channel-Homo sapiens-1Inhibition15251227 | 11031246
158EFF1444Voltage dependent N type calcium channel-Homo sapiens-10Inhibition15251227 | 11031246
159EFF1445Voltage dependent N type calcium channel-Homo sapiens-11Inhibition15251227 | 11031246
160EFF1446Voltage dependent N type calcium channel-Homo sapiens-12Inhibition15251227 | 11031246
161EFF1447Voltage dependent N type calcium channel-Homo sapiens-13Inhibition15251227 | 11031246
162EFF1448Voltage dependent N type calcium channel-Homo sapiens-14Inhibition15251227 | 11031246
163EFF1449Voltage dependent N type calcium channel-Homo sapiens-7Inhibition15251227 | 11031246
164EFF1450Voltage dependent N type calcium channel-Homo sapiens-6Inhibition15251227 | 11031246
165EFF1451Voltage dependent N type calcium channel-Homo sapiens-5Inhibition15251227 | 11031246
166EFF1452Voltage dependent N type calcium channel-Homo sapiens-4Inhibition15251227 | 11031246
167EFF1453Voltage dependent N type calcium channel-Homo sapiens-2Inhibition15251227 | 11031246
168EFF1454Voltage dependent N type calcium channel-Homo sapiens-3Inhibition15251227 | 11031246
169EFF1459Voltage dependent N type calcium channel-Homo sapiens-8Inhibition15251227 | 11031246
170EFF1460Voltage dependent N type calcium channel-Homo sapiens-9Inhibition15251227 | 11031246
171EFF1472Voltage dependent P/Q type calcium channel-Homo sapiens-1Inhibition15251227 | 11031246
172EFF1473Voltage dependent P/Q type calcium channel-Homo sapiens-2Inhibition15251227 | 11031246
173EFF1474Voltage dependent P/Q type calcium channel-Homo sapiens-3Inhibition15251227 | 11031246
174EFF1475Voltage dependent P/Q type calcium channel-Homo sapiens-4Inhibition15251227 | 11031246
175EFF1476Voltage dependent P/Q type calcium channel-Homo sapiens-5Inhibition15251227 | 11031246
176EFF1477Voltage dependent P/Q type calcium channel-Homo sapiens-6Inhibition15251227 | 11031246
177EFF1498Voltage dependent R type calcium channel-Homo sapiens-1Inhibition15251227 | 11031246
178EFF1499Voltage dependent R type calcium channel-Homo sapiens-2Inhibition15251227 | 11031246
179EFF1503Voltage dependent R type calcium channel-Homo sapiens-5Inhibition15251227 | 11031246
180EFF1504Voltage dependent R type calcium channel-Homo sapiens-4Inhibition15251227 | 11031246
181EFF1505Voltage dependent R type calcium channel-Homo sapiens-3Inhibition15251227 | 11031246

Coupling with GPCRs:
No information



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