gpDB: a database of G-proteins and their interaction with GPCRs
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gpDB::Effector View
Entry 1 of 1 :: EFF1499 ::
FAMILY Ion channels
SUBFAMILY Voltage dependent calcium channels
TYPE Voltage dependent R type calcium channel

Cross References:
UniProt Q15878 | Q14580 | Q14581 EMBL L27745 | L29384 | L29385
InterPro IPR002048 | IPR005821 | IPR014873 | IPR005449 | IPR002077
MIM 601013
PRINTS PR00167 | PR01633 PFAM PF08763 | PF00520

Details:
NAME Voltage dependent R type calcium channel-Homo sapiens-2
DESCRIPTION Voltage-dependent R-type calcium channel subunit alpha-1E (Voltage-gated calcium channel subunit alpha Cav2.3) (Calcium channel, L type,alpha-1 polypeptide, isoform 6) (Brain calcium channel II) (BII).
SPECIES Homo sapiens COMMON NAME Human NCBI Taxonomy 9606
GENE CACNA1E | CACH6 | CACNL1A6
SEQUENCE
MARFGEAVVARPGSGDGDSDQSRNRQGTPVPASGQAAAYKQTKAQRARTMALYNPIPVRQ
NCFTVNRSLFIFGEDNIVRKYAKKLIDWPPFEYMILATIIANCIVLALEQHLPEDDKTPM
SRRLEKTEPYFIGIFCFEAGIKIVALGFIFHKGSYLRNGWNVMDFIVVLSGILATAGTHF
NTHVDLRTLRAVRVLRPLKLVSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGL
EFYSGKLHRACFMNN
FRAGMENT NO
FUNCTION Voltage-sensitive calcium channels (VSCC) mediate thes entry of calcium ions into excitable cells and are also involveds in a variety of calcium-dependent processes, including muscles contraction, hormone or neurotransmitter release, gene expression,s ce
Interacting with G-proteins:
Family:Gi/o REFERENCES:15251227 | 11031246
1GPR0020Galpha-o1-Homo sapiens
2GPR0334Galpha-o-Homo sapiens
Family:Gbeta REFERENCES:15251227 | 11031246
3GPR0147Gbeta-1-Homo sapiens
4GPR0155Gbeta-2-Homo sapiens
5GPR0160Gbeta-3-Homo sapiens-1
6GPR0164Gbeta-4-Homo sapiens
7GPR0167Gbeta-5-Homo sapiens-2
8GPR0363Gbeta-3-Homo sapiens-2
9GPR0366Gbeta-5-Homo sapiens-1
10GPR0402unclassified_Gbeta-Homo sapiens
Family:Ggamma REFERENCES:15251227 | 11031246
11GPR0176Ggamma-t1-Homo sapiens
12GPR0179Ggamma-2-Homo sapiens
13GPR0183Ggamma-3-Homo sapiens
14GPR0185Ggamma-4-Homo sapiens
15GPR0188Ggamma-5-Homo sapiens-2
16GPR0192Ggamma-7-Homo sapiens
17GPR0195Ggamma-8-Homo sapiens-2
18GPR0198Ggamma-10-Homo sapiens-2
19GPR0199Ggamma-11-Homo sapiens
20GPR0203Ggamma-12-Homo sapiens
21GPR0205Ggamma-13-Homo sapiens
22GPR0210Ggamma-8-Homo sapiens-1
23GPR0253Ggamma-5-Homo sapiens-1
24GPR0364Ggamma-10-Homo sapiens-1


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athina University of Athens
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Dept. of Cell Biology and Biophysics
Biophysics
& Bioinformatics
Laboratory