gpDB: a database of G-proteins and their interaction with GPCRs
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gpDB::Effector View
Entry 1 of 1 :: EFF0696 ::
FAMILY Guanine nucleotide releasing factors
SUBFAMILY Ras specific nucleotide releasing factors
TYPE Ras specific nucleotide exchange factor CDC25

Cross References:
UniProt Q13972 | Q16027 EMBL L26584 | S62035 | M91815
InterPro IPR000219 | IPR001331 | IPR000048 | IPR001849 | IPR011993 | IPR008937 | IPR000651 | IPR001895
GENEID 5923 MIM 606600
PFAM PF00612 | PF00169 | PF00617 | PF00618 | PF00621

Details:
NAME Ras specific nucleotide exchange factor CDC25-Homo sapiens
DESCRIPTION Ras-specific guanine nucleotide-releasing factor 1 (Ras-GRF1) (Guaninenucleotide-releasing protein) (Ras-specific nucleotide exchange factorCDC25) (Guanine nucleotide-releasing factor 1).
SPECIES Homo sapiens COMMON NAME Human NCBI Taxonomy 9606
GENE RASGRF1 | CDC25 | GNRP | GRF1
SEQUENCE 
MQKAIRLNDGHVAPLGLLARKDGTRKGYLSKRSSDNTKWQTKWFALLQNLLFYFESDSSS
RPSGLYLLEGCVCDRAPSPKPALSAKEPLEKQHYFTVNFSHENQKALELRTEDAKDCDEW
VAAIAHASYRTLATEHEALMQKYLHLLQIVETEKTVAKQLRQQIEDGEIEIERLKAEITS
LLKDNERIQSTQTVAPNDEDSDIKKIKKVQSFLRGWLCRRKWKTIIQDYIRSPHADSMRK
RNQVVFSMLEAEAEY
 FRAGMENT NO
FUNCTION Promotes the exchange of Ras-bound GDP by GTP
Interacting with G-proteins:
Family:Gbeta REFERENCES:15251227 | 8717044
1GPR0147Gbeta-1-Homo sapiens
2GPR0155Gbeta-2-Homo sapiens
3GPR0160Gbeta-3-Homo sapiens-1
4GPR0164Gbeta-4-Homo sapiens
5GPR0167Gbeta-5-Homo sapiens-2
6GPR0363Gbeta-3-Homo sapiens-2
7GPR0366Gbeta-5-Homo sapiens-1
8GPR0402unclassified_Gbeta-Homo sapiens
Family:Ggamma REFERENCES:15251227 | 8717044
9GPR0176Ggamma-t1-Homo sapiens
10GPR0179Ggamma-2-Homo sapiens
11GPR0183Ggamma-3-Homo sapiens
12GPR0185Ggamma-4-Homo sapiens
13GPR0188Ggamma-5-Homo sapiens-2
14GPR0192Ggamma-7-Homo sapiens
15GPR0195Ggamma-8-Homo sapiens-2
16GPR0198Ggamma-10-Homo sapiens-2
17GPR0199Ggamma-11-Homo sapiens
18GPR0203Ggamma-12-Homo sapiens
19GPR0205Ggamma-13-Homo sapiens
20GPR0210Ggamma-8-Homo sapiens-1
21GPR0253Ggamma-5-Homo sapiens-1
22GPR0364Ggamma-10-Homo sapiens-1

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athina University of Athens
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