gpDB::G-protein View

CLASS	Galpha
FAMILY	Gi/o
SUBFAMILY	Galpha-i
TYPE	Galpha-i

Cross References:
UniProt	O93565	EMBL	AF086606
InterPro	IPR001019 \| IPR001408 \| IPR011025
PRODOM	PD000281
PRINTS	PR00318 \| PR00441	PFAM	PF00503

Details:
NAME	Galpha-i-Xenopus laevis
DESCRIPTION	Guanine nucleotide-binding protein Gi alpha subunit .
SPECIES	Xenopus laevis	COMMON NAME	African clawed frog	NCBI Taxonomy	8355
POST TRANSLATION MODIFICATIONS	null	GENE	-
SEQUENCE	MGCTSSAEDKAAAERSKMIDKNLREDGEKAAREVKLLLLGAGESGKSTIVKQMKIIHEDG YSEEECRQYRAVVFSNTIQSIMAIIKAMGNLKIDFGDSARADDARQLFALSCSAEEQGVL PEDLSGVIRRLWADHGVQACFNRSREYQLNDSAAYYLNDLERIARSDYLPTQQDVLRTRV KTTGIVETHFTFKDLHFKMFDVGGQRSERKKWIHCFEGVTAIIFCVALSAYDLVLAEDEE MNRMHESMKLFDSIWNNKWFTETSIILFLNKKDLFEEKITHSPLTICFPEYTGANKYDEA ASYIHSKFEDLNKRKDTKEIYTHFTCATDTKNVEFVFDAVTDVIIKNNLK				FRAGMENT	YES
FUNCTION	-

Effectors:
1	EFF0043	Adenylate cyclase-6-Xenopus laevis	Inhibition	15251227 \| 15922020 \| 14993377 \| 11376933
2	EFF0407	Kir 3.1(GIRK1)-Xenopus laevis-1	Stimulation	15251227 \| 14963032 \| 11779482
3	EFF0408	Kir 3.1(GIRK1)-Xenopus laevis-2	Stimulation	15251227 \| 14963032 \| 11779482
4	EFF0672	Rac-Xenopus laevis	Stimulation	11099498
5	EFF0871	Src tyrosine kinase-Xenopus laevis	Stimulation	11007482 \| 15251227 \| 12209124
6	EFF1382	Tubulin-Xenopus laevis-1	Stimulation of GTPase activity	10224115 \| 15251227 \| 16380086
7	EFF1384	Tubulin-Xenopus laevis-11	Stimulation of GTPase activity	10224115 \| 15251227 \| 16380086
8	EFF1385	Tubulin-Xenopus laevis-12	Stimulation of GTPase activity	10224115 \| 15251227 \| 16380086
9	EFF1386	Tubulin-Xenopus laevis-13	Stimulation of GTPase activity	10224115 \| 15251227 \| 16380086
10	EFF1387	Tubulin-Xenopus laevis-14	Stimulation of GTPase activity	10224115 \| 15251227 \| 16380086
11	EFF1388	Tubulin-Xenopus laevis-15	Stimulation of GTPase activity	10224115 \| 15251227 \| 16380086
12	EFF1389	Tubulin-Xenopus laevis-16	Stimulation of GTPase activity	10224115 \| 15251227 \| 16380086
13	EFF1390	Tubulin-Xenopus laevis-17	Stimulation of GTPase activity	10224115 \| 15251227 \| 16380086
14	EFF1391	Tubulin-Xenopus laevis-18	Stimulation of GTPase activity	10224115 \| 15251227 \| 16380086
15	EFF1392	Tubulin-Xenopus laevis-19	Stimulation of GTPase activity	10224115 \| 15251227 \| 16380086
16	EFF1393	Tubulin-Xenopus laevis-2	Stimulation of GTPase activity	10224115 \| 15251227 \| 16380086
17	EFF1394	Tubulin-Xenopus laevis-20	Stimulation of GTPase activity	10224115 \| 15251227 \| 16380086
18	EFF1395	Tubulin-Xenopus laevis-21	Stimulation of GTPase activity	10224115 \| 15251227 \| 16380086
19	EFF1396	Tubulin-Xenopus laevis-22	Stimulation of GTPase activity	10224115 \| 15251227 \| 16380086
20	EFF1397	Tubulin-Xenopus laevis-23	Stimulation of GTPase activity	10224115 \| 15251227 \| 16380086
21	EFF1398	Tubulin-Xenopus laevis-24	Stimulation of GTPase activity	10224115 \| 15251227 \| 16380086
22	EFF1399	Tubulin-Xenopus laevis-25	Stimulation of GTPase activity	10224115 \| 15251227 \| 16380086
23	EFF1400	Tubulin-Xenopus laevis-26	Stimulation of GTPase activity	10224115 \| 15251227 \| 16380086
24	EFF1401	Tubulin-Xenopus laevis-27	Stimulation of GTPase activity	10224115 \| 15251227 \| 16380086
25	EFF1402	Tubulin-Xenopus laevis-28	Stimulation of GTPase activity	10224115 \| 15251227 \| 16380086
26	EFF1403	Tubulin-Xenopus laevis-10	Stimulation of GTPase activity	10224115 \| 15251227 \| 16380086
27	EFF1404	Tubulin-Xenopus laevis-3	Stimulation of GTPase activity	10224115 \| 15251227 \| 16380086
28	EFF1405	Tubulin-Xenopus laevis-9	Stimulation of GTPase activity	10224115 \| 15251227 \| 16380086
29	EFF1406	Tubulin-Xenopus laevis-4	Stimulation of GTPase activity	10224115 \| 15251227 \| 16380086
30	EFF1407	Tubulin-Xenopus laevis-5	Stimulation of GTPase activity	10224115 \| 15251227 \| 16380086
31	EFF1408	Tubulin-Xenopus laevis-6	Stimulation of GTPase activity	10224115 \| 15251227 \| 16380086
32	EFF1409	Tubulin-Xenopus laevis-7	Stimulation of GTPase activity	10224115 \| 15251227 \| 16380086
33	EFF1410	Tubulin-Xenopus laevis-8	Stimulation of GTPase activity	10224115 \| 15251227 \| 16380086

Coupling with GPCRs:
1	GPCR0018	5-HYDROXYTRYPTAMINE RECEPTOR_5-HT-1A_Xenopus laevis	3138543
2	GPCR0169	ADENOSINE RECEPTOR_A1_Xenopus laevis	1662665
3	GPCR0410	ANGIOTENSIN RECEPTOR_AT1_Xenopus laevis-1	1310139
4	GPCR0415	ANGIOTENSIN RECEPTOR_AT1_Xenopus laevis-2	1310139
5	GPCR0606	CHEMOKINE RECEPTOR (CC)_CXCR4_Xenopus laevis	8629022
6	GPCR0774	DOPAMINE RECEPTOR_D2_Xenopus laevis-1	2974511
7	GPCR0776	DOPAMINE RECEPTOR_D2_Xenopus laevis-2	2974511
8	GPCR2729	FRIZZLED_Frizzled-1_Xenopus laevis	11563835
9	GPCR0857	GLYCOPROTEIN HORMONE RECEPTOR_FSH RECEPTOR_Xenopus laevis	9139796
10	GPCR1017	LYSOPHOSPHOLIPID RECEPTOR_LPA3_Xenopus laevis	12069829
11	GPCR0876	GLYCOPROTEIN HORMONE RECEPTOR_LSH RECEPTOR_Xenopus laevis	1516719
12	GPCR0147	ACETYLCHOLINE RECEPTOR (MUSCARINIC)_M4_Xenopus laevis	3037705
13	GPCR1216	MELATONIN RECEPTOR_MT1_Xenopus laevis-2	7946354
14	GPCR1223	MELATONIN RECEPTOR_MT1_Xenopus laevis-1	7946354
15	GPCR1227	MELATONIN RECEPTOR_MT2_Xenopus laevis	12721330
16	GPCR2457	PROTEASE-ACTIVATED RECEPTOR_PAR1_Xenopus laevis	10644723
17	GPCR1071	LYSOPHOSPHOLIPID RECEPTOR_S1P1_Xenopus laevis-1	9488656
18	GPCR1080	LYSOPHOSPHOLIPID RECEPTOR_S1P1_Xenopus laevis-2	9488656
19	GPCR2807	SMOOTHENED_smoothened_Xenopus laevis	10835429
20	GPCR1252	NEUROPEPTIDE Y RECEPTOR_Y1_Xenopus laevis	1321422


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	University of Athens Faculty of Biology Dept. of Cell Biology and Biophysics	Biophysics & Bioinformatics Laboratory