gpDB: a database of G-proteins and their interaction with GPCRs
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gpDB::GPCR View
Entry 1 of 1 :: GPCR0876 ::
CLASS CLASS A (RHODOPSIN LIKE)
FAMILY GLYCOPROTEIN HORMONE RECEPTOR
SUBFAMILY LSH RECEPTOR

Cross References:
UniProt Q9PU15 EMBL AJ249845
InterPro IPR000276 | IPR002131 GPCRDB q9pu15_xenla
PRINTS PR00373 | PR00237 PFAM PF00001

Details:
NAME GLYCOPROTEIN HORMONE RECEPTOR_LSH RECEPTOR_Xenopus laevis
DESCRIPTION Luteinizing hormone receptor .
SPECIES Xenopus laevis COMMON NAME African clawed frog NCBI Taxonomy 8355
GENE lhr
SEQUENCE 
RLLMCNLSFADFCMGIYLLLIASVDSQTRSQYYNHAIDWQTGSGCSAAGFFTVFSSELSV
YTLTVITLERWHTITYAMQLDRKLRLRHAILIMLGGWIFSLVIAMLPLVGVSNYIKVSIC
LPMDIETPLSQAYIIFILVLNVTAFIIICACYIKIYIAVQNPELTPTNKDTKLA
 FRAGMENT YES

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Dimerization:
HOMODIMER INFORMATION There is experimental evidence for homo-dimerization METHOD Photobleaching Fluorescence Resonance Energy Transfer (FRET) REFERENCES 11108263

Scaffold:
TYPE GIPC( GAIP-interacting protein) REFERENCES 14507927
TYPE NHERF1( Na+/H+ exchange regulatory factor) /EBP50( ezrin-radixin-moesin binding phosphoprotein 50-kD protein) REFERENCES 14507927
TYPE p38JAB1 REFERENCES 10788448

Coupling with G-proteins:
Family:Gi/o REFERENCES:1516719
1GPR0016Galpha-o-Xenopus laevis
2GPR0112Galpha-i3-Xenopus laevis
3GPR0222Galpha-i1-Xenopus laevis
4GPR0271Galpha-o1-Xenopus laevis
5GPR0272Galpha-i-Xenopus laevis
Family:Gq/11 REFERENCES:1516719
6GPR0033Galpha-11-Xenopus laevis-2
7GPR0243Galpha-q-Xenopus laevis
8GPR0314Galpha-11-Xenopus laevis-1
Family:Gs REFERENCES:1516719
9GPR0127Galpha-s-Xenopus laevis

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