gpDB: a database of G-proteins and their interaction with GPCRs
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gpDB::GPCR View
Entry 1 of 1 :: GPCR1252 ::
CLASS CLASS A (RHODOPSIN LIKE)
FAMILY NEUROPEPTIDE Y RECEPTOR
SUBFAMILY Y1

Cross References:
UniProt P34992 EMBL L25416
InterPro IPR000276 | IPR000351 | IPR000611 GPCRDB npy1r_xenla
GENEID 378693
PRINTS PR00237 | PR01013 | PR01012 PFAM PF00001

Details:
NAME NEUROPEPTIDE Y RECEPTOR_Y1_Xenopus laevis
DESCRIPTION Neuropeptide Y receptor type 1 (NPY1-R).
SPECIES Xenopus laevis COMMON NAME African clawed frog NCBI Taxonomy 8355
GENE npy1r
SEQUENCE 
MNFSTYFENLSVPNNISGNITFPISEDCALPLPMIFTLALAYGAVIILGLSGNLALIIII
LKQKEMRNVTNILIVNLSFSDLLATIMCLPFTLIYTLMDHWIFGEVMCKLNEYIQCVSVT
VSIFSLVLIAIERHQLIINPRGWRPNNRHACFGITVIWGFAMACSTPLMMYSVLTDEPFK
NISLDSYIGKYVCLEDFPEDKFRLSYTTLLFILQYLGPLCFIFVCYTKIFLRLKRRNNMM
DKIRDNKYRSSETKRINIMLLSIVVGFALCWLPFFIFNLVFDWNHEAVATCNHNLLFLIC
HLTAMISTCVNPIFYGFLNKNFQRDLQFFFNFCDFRSREDDYETIAMSTMHTDVSKTSLK
QASPIA
 FRAGMENT NO

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Dimerization:
HOMODIMER INFORMATION There is experimental evidence for homo-dimerization METHOD Fluorescence Resonance Energy Transfer (FRET) REFERENCES 12524448

Coupling with G-proteins:
Family:Gi/o REFERENCES:1321422
1GPR0016Galpha-o-Xenopus laevis
2GPR0112Galpha-i3-Xenopus laevis
3GPR0222Galpha-i1-Xenopus laevis
4GPR0271Galpha-o1-Xenopus laevis
5GPR0272Galpha-i-Xenopus laevis
Family:Gq/11 REFERENCES:1321422
6GPR0033Galpha-11-Xenopus laevis-2
7GPR0243Galpha-q-Xenopus laevis
8GPR0314Galpha-11-Xenopus laevis-1

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athina University of Athens
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 Dept. of Cell Biology and Biophysics
Biophysics
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Laboratory