gpDB: a database of G-proteins and their interaction with GPCRs
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gpDB::GPCR View
Entry 1 of 1 :: GPCR1216 ::
CLASS CLASS A (RHODOPSIN LIKE)
FAMILY MELATONIN RECEPTOR
SUBFAMILY MT1

Cross References:
UniProt P51048 EMBL U31826
InterPro IPR000276 | IPR000025 GPCRDB mtr1a_xenla
PRINTS PR00237 | PR00857 PFAM PF00001

Details:
NAME MELATONIN RECEPTOR_MT1_Xenopus laevis-2
DESCRIPTION Melatonin receptor type 1A X2.0 .
SPECIES Xenopus laevis COMMON NAME African clawed frog NCBI Taxonomy 8355
GENE -
SEQUENCE
HSSWYNRLFSNSGTICYVGLVWVLALGAILPNLFVGSLRCDPRIFSCTFAQYVSSYYTIA
VVIFHFFLPIGVVSYCYLRIWVLVLNIRHRVKPDRHLHHQTWPYNIHGFITMFVVFVLFA
VCWGPLNIIGLTVAIYPPLGDSIPQWLFVASYF
FRAGMENT YES

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Dimerization:
HOMODIMER INFORMATION There is experimental evidence for homo-dimerization METHOD Immunoprecipitation, Bioluminescence Resonance Energy Transfer (BRET) REFERENCES 11940583
HETERODIMER INFORMATION Forms heterodimers with Melatonin MT2 Receptors. METHOD Immunoprecipitation, Bioluminescence Resonance Energy Transfer (BRET) REFERENCES 11940583

Coupling with G-proteins:
Family:Gi/o REFERENCES:7946354
1GPR0016Galpha-o-Xenopus laevis
2GPR0112Galpha-i3-Xenopus laevis
3GPR0222Galpha-i1-Xenopus laevis
4GPR0271Galpha-o1-Xenopus laevis
5GPR0272Galpha-i-Xenopus laevis


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