gpDB: a database of G-proteins and their interaction with GPCRs
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gpDB::GPCR View
Entry 1 of 1 :: GPCR2807 ::
CLASS FRIZZLED/SMOOTHENED
FAMILY SMOOTHENED
SUBFAMILY smoothened

Cross References:
UniProt Q98SW5 EMBL AF302766
InterPro IPR000539 | IPR000024 | IPR015526 | IPR000832 GPCRDB q98sw5_xenla
GENEID 398216
PRINTS PR00489 PFAM PF01534 | PF01392

Details:
NAME SMOOTHENED_smoothened_Xenopus laevis
DESCRIPTION Smoothened.
SPECIES Xenopus laevis COMMON NAME African clawed frog NCBI Taxonomy 8355
GENE Smo
SEQUENCE
MSSMVPWICWIGGFGFLLFICTSGGVQINETFYMDKCKKTTTCEPLKYNICLGSVLPYAL
TSTVLAEDSSSQDEVHDKLSLWSGLRNAPRCWDAIRPLLCAVYMPKCEGGKVELPSQGLC
QTTRVPCAIVARERGWPDFLKCTTDYFPEGCPNEVQNIKFNSSGQCEAPLVRTDNPKSWY
EDVEGCGIQCQNPLFTNKEHREMHIYIAIFSSVTIFCTFFTLATFLADWKNSNRYPAVIL
FYVNACFFVGSIGWLAQFMDGARDEIVCRGDGTMRLGEPTSNETLSCVIIFIIVYYSMMS
GVIWFVMLTYAWHTSFKALGTTHQPLSGKTSYFHLITWSIPFVLTVAILAVAQVDGDSVS
GICFVGYKNYHYRAGFVLAPIGLVLIGGGYFLIRGVMTLFSIKSNHPGLLSEKAASKINE
TMLRLGIFGFLAFGFVLITFGCHFYDFFNQAEWERSFREYVLCEANVTIAEQTNKPIPEC
YIKNRPSLLVEKINLFAMFGTGISMSTWVWTKATIIIWKRAWCRILGRSDDEPKRIKKSK
MIAKAFSKRKELLNNPEKELSFSLHSVSHEGPVAGLNFDMNEPSADMSSAWAQHVTKMVA
RRGAILPQDVSVTPVATPVPPEERDQWFIEGDIPQGMVKKMSKKKKRRKKKEIQPLEAKT
VKEHFHSRANTAVPRLPKLPLKTGLVTRSKPQEVDETLPGSYREFRRLPNIQEKLYPVEG
VNNNLGYTRYPQSNMISHPFAADKMPLTDESRVAYVPVPKHDGVFQYSSANSYSNPMDLT
SYRGRTQPRWTENPPMHSRANLMDAELMDTDSDF
FRAGMENT NO

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Coupling with G-proteins:
Family:Gi/o REFERENCES:10835429
1GPR0016Galpha-o-Xenopus laevis
2GPR0112Galpha-i3-Xenopus laevis
3GPR0222Galpha-i1-Xenopus laevis
4GPR0271Galpha-o1-Xenopus laevis
5GPR0272Galpha-i-Xenopus laevis


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athina University of Athens
Faculty of Biology
Dept. of Cell Biology and Biophysics
Biophysics
& Bioinformatics
Laboratory