gpDB: a database of G-proteins and their interaction with GPCRs
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gpDB::GPCR View
Entry 1 of 1 :: GPCR0776 ::
CLASS CLASS A (RHODOPSIN LIKE)
FAMILY DOPAMINE RECEPTOR
SUBFAMILY D2

Cross References:
UniProt P34973 EMBL X72902
InterPro IPR001922 | IPR000929 | IPR000276 GPCRDB drd2b_xenla
PRINTS PR00567 | PR00242 | PR00237 PFAM PF00001

Details:
NAME DOPAMINE RECEPTOR_D2_Xenopus laevis-2
DESCRIPTION D.
SPECIES Xenopus laevis COMMON NAME African clawed frog NCBI Taxonomy 8355
GENE drd2-B
SEQUENCE
EWRFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISV
VWVLSFAISCPLLFGLNNTASTVCIIDNPAFVIYSSIVSFYVPFIVTLLVYVQIYIVLRK
RRKRVNTKRNSHGVGVDAHKDKCTHPEDVKLCAVFVKSNGSFPAEKKKVEAGNHPEDMEM
EMMSSTSPPEKTKHKSASPEHQLAVPATSNQCNNVNLPTPVNSPYKAENNGHSKDSTQPA
KVFEIQSMPNGKTRTSIKTMSKRKISQHKEKKATQMLAIVLGVFIICWLPFFITHILNMH
CNCNIPQALYSAFTWLGYVNSAVNPIIYTTFNVEFRKAFIKILHC
FRAGMENT YES

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Dimerization:
HOMODIMER INFORMATION There is experimental evidence for homo-dimerization METHOD Fluorescence Resonance Energy Transfer (FRET) REFERENCES 11682068
HOMODIMER INFORMATION There is experimental evidence for homo-dimerization METHOD Immunoprecipitation REFERENCES 10860933
HETERODIMER INFORMATION Forms heterodimers with Dopamine D3 Receptors. Dimerization results in an Increased affnity and potency for agonists and antagonists METHOD Functional reconstitution REFERENCES 11373283
HETERODIMER INFORMATION Forms heterodimer with Somatostatin SST5 Receptor. Dimerization results in increased ligand binding affnity and enhanced signalling METHOD Photobleaching Fluorescence Resonance Energy Transfer (FRET) REFERENCES 10753124
HETERODIMER INFORMATION Forms heterodimers with Adenosine A2A Receptor. Heterodimerization results in co-desensitization and co-internalization of the receptors METHOD Immunoprecipitation REFERENCES 11872740

Scaffold:
TYPE alpha-filamin/ABP280( actin binding protein 280) REFERENCES 11911837 | 1239393
TYPE Protein 4.1N REFERENCES 12181426
TYPE Spinophilin/neurabin II REFERENCES 10391935

Coupling with G-proteins:
Family:Gi/o REFERENCES:2974511
1GPR0016Galpha-o-Xenopus laevis
2GPR0112Galpha-i3-Xenopus laevis
3GPR0222Galpha-i1-Xenopus laevis
4GPR0271Galpha-o1-Xenopus laevis
5GPR0272Galpha-i-Xenopus laevis


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athina University of Athens
Faculty of Biology
Dept. of Cell Biology and Biophysics
Biophysics
& Bioinformatics
Laboratory