gpDB: a database of G-proteins and their interaction with GPCRs
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gpDB::G-protein View
Entry 1 of 1 :: GPR0036 ::
CLASS Galpha
FAMILY G12/13
SUBFAMILY Galpha-12
TYPE Galpha-12

Cross References:
UniProt Q63210 EMBL D85760
InterPro IPR001019 | IPR000469 | IPR011025
PRODOM PD000281
GENEID 81663
PRINTS PR00318 | PR00440 PFAM PF00503

Details:
NAME Galpha-12-Rattus norvegicus
DESCRIPTION Guanine nucleotide-binding protein alpha-12 subunit (G alpha-12).
SPECIES Rattus norvegicus COMMON NAME Rat NCBI Taxonomy 10116
POST TRANSLATION MODIFICATIONS null GENE Gna12
SEQUENCE 
MSGVVRTLSRCLLPAEAGARERRAGAARDAEREARRRSRDIDALLARERRAVRRLVKILL
LGAGESGKSTFLKQMRIIHGREFDQKALLEFRDTIFDNILKGSRVLVDARDKLGIPWQHS
ENEKHGMFLMAFENKAGLPVEPATFQLYVPALSALWRDSGIREAFSRRSEFQLGESVKYF
LDNLDRIGQLNYFPSKQDILLARKATKGIVEHDFVIKKIPFKMVDVGGQRSQRQKWFQCF
DGITSILFMVSSSEYDQVLMEDRRTNRLVESMNIFETIVNNKLFFNVSIILFLNKMDLLV
EKVKSVSIKKHFPDFKGDPHRLEDVQRYLVQCFDRKRRNRGKPLFHHFTTAIDTENIRFV
FHAVKDTILQENLKDIMLQ
 FRAGMENT NO
FUNCTION Guanine nucleotide-binding proteins (G proteins) ares involved as modulators or transducers in various transmembranes signaling systems
Effectors:
1EFF0331E cadherin-Rattus norvegicusStimulation (stimulation of h-catenin release)15251227 | 14607242 | 11136230
2EFF0440LARG RhoGEF-Rattus norvegicusStimulation (indirect activation of Rho and stress fiber formation)15251227 | 12024019 | 14607242
3EFF0452PDZ RhoGEF-Rattus norvegicusStimulation (indirect activation of Rho and stress fiber formation)15251227 | 11799111 | 14607242
4EFF0695Ras GTPase activating protein-2-Rattus norvegicusStimulation (indirect activation of ras)15251227

Coupling with GPCRs:
1GPCR00865-HYDROXYTRYPTAMINE RECEPTOR_5-HT-2C_Rattus norvegicus14722258 | 11572865
2GPCR00885-HYDROXYTRYPTAMINE RECEPTOR_5-HT-4_Rattus norvegicus11923294
3GPCR0206ADRENOCEPTOR (A1-ADRENOCEPTOR)_A1A(Adrenoceptor)_Rattus norvegicus12433842
4GPCR0411ANGIOTENSIN RECEPTOR_AT1_Rattus norvegicus-19092554 | 9287322
5GPCR0430ANGIOTENSIN RECEPTOR_AT1_Rattus norvegicus-29092554 | 9287322
6GPCR0473BRADYKININ RECEPTOR_B2_Rattus norvegicus7946358
7GPCR0451BOMBESIN RECEPTOR_BB2_Rattus norvegicus11507098
8GPCR0702CHEMOTACTIC PEPTIDE RECEPTOR_C3A_Rattus norvegicus12165538
9GPCR2639EXTRACELLULAR CALCIUM-SENSING RECEPTOR_CASR_Rattus norvegicus12954603
10GPCR0735CHOLECYSTOKININ AND GASTRIN RECEPTOR_CCK1_Rattus norvegicus12853286
11GPCR0809DOPAMINE RECEPTOR_D5_Rattus norvegicus12623966
12GPCR0817ENDOTHELIN RECEPTOR_ET-A_Rattus norvegicus10364236
13GPCR0824ENDOTHELIN RECEPTOR_ET-B_Rattus norvegicus10199825
14GPCR0836GALANIN RECEPTOR_GAL2_Rattus norvegicus10980593
15GPCR1005LYSOPHOSPHOLIPID RECEPTOR_LPA1_Rattus norvegicus9600933
16GPCR1014LYSOPHOSPHOLIPID RECEPTOR_LPA3_Rattus norvegicus12069829
17GPCR0121ACETYLCHOLINE RECEPTOR (MUSCARINIC)_M1_Rattus norvegicus10821841
18GPCR0141ACETYLCHOLINE RECEPTOR (MUSCARINIC)_M3_Rattus norvegicus11036069
19GPCR2498TACHYKININ RECEPTOR_NK1_Rattus norvegicus8999927
20GPCR2455PROTEASE-ACTIVATED RECEPTOR_PAR1_Rattus norvegicus12954641
21GPCR1088LYSOPHOSPHOLIPID RECEPTOR_S1P2_Rattus norvegicus10488065
22GPCR1094LYSOPHOSPHOLIPID RECEPTOR_S1P3_Rattus norvegicus10488065
23GPCR1101LYSOPHOSPHOLIPID RECEPTOR_S1P5_Rattus norvegicus10799507
24GPCR2803SMOOTHENED_smoothened_Rattus norvegicus14723707
25GPCR2450PROSTANOID RECEPTOR_TP_Rattus norvegicus10318854
26GPCR0881GLYCOPROTEIN HORMONE RECEPTOR_TSH RECEPTOR_Rattus norvegicus8552586
27GPCR2562VASOPRESSIN AND OXYTOCIN RECEPTOR_V1A_Rattus norvegicus10364236



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