gpDB: a database of G-proteins and their interaction with GPCRs
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gpDB::GPCR View
Entry 1 of 1 :: GPCR0473 ::
CLASS CLASS A (RHODOPSIN LIKE)
FAMILY BRADYKININ RECEPTOR
SUBFAMILY B2

Cross References:
UniProt P25023 EMBL M59967 | M59967 | X80187 | X80188 | X80189 | X80190 | L26173 | X69681
InterPro IPR001504 | IPR000496 | IPR000276 GPCRDB bkrb2_rat
GENEID 25245
PRINTS PR00425 | PR00994 | PR00237 PFAM PF00001

Details:
NAME BRADYKININ RECEPTOR_B2_Rattus norvegicus
DESCRIPTION B2 bradykinin receptor (BK-2 receptor) (B2R).
SPECIES Rattus norvegicus COMMON NAME Rat NCBI Taxonomy 10116
GENE Bdkrb2
SEQUENCE
MDTRSSLCPKTQAVVAVFWGPGCHLSTCIEMFNITTQALGSAHNGTFSEVNCPDTEWWSW
LNAIQAPFLWVLFLLAALENIFVLSVFCLHKTNCTVAEIYLGNLAAADLILACGLPFWAI
TIANNFDWLFGEVLCRVVNTMIYMNLYSSICFLMLVSIDRYLALVKTMSMGRMRGVRWAK
LYSLVIWSCTLLLSSPMLVFRTMKDYREEGHNVTACVIVYPSRSWEVFTNMLLNLVGFLL
PLSIITFCTVRIMQVLRNNEMKKFKEVQTEKKATVLVLAVLGLFVLCWFPFQISTFLDTL
LRLGVLSGCWNERAVDIVTQISSYVAYSNSCLNPLVYVIVGKRFRKKSREVYQAICRKGG
CMGESVQMENSMGTLRTSISVDRQIHKLQDWAGNKQ
FRAGMENT NO

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Dimerization:
HOMODIMER INFORMATION There is experimental evidence for homo-dimerization METHOD Cross-linking in the presence of agonist REFERENCES 10473556
HETERODIMER INFORMATION Forms heterodimer with Angiotensin AT1 Receptor. Dimerization results in increased signalling activity METHOD Immunoprecipitation REFERENCES 10993080

Scaffold:
TYPE eNOS( endothelial nitric oxide synthase) /cNOS/NOS3 REFERENCES 10681501
TYPE nNOS( neuronal nitric oxide synthase) NOS1 REFERENCES 10681501

Coupling with G-proteins:
Family:G12/13 REFERENCES:7946358
1GPR0036Galpha-12-Rattus norvegicus
Family:Gq/11 REFERENCES:1657928
2GPR0032Galpha-11-Rattus norvegicus
3GPR0242Galpha-q-Rattus norvegicus


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athina University of Athens
Faculty of Biology
Dept. of Cell Biology and Biophysics
Biophysics
& Bioinformatics
Laboratory