gpDB: a database of G-proteins and their interaction with GPCRs
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gpDB::Effector View
Entry 1 of 1 :: EFF0452 ::
FAMILY Guanine nucleotide exchange factors
SUBFAMILY RhoGEFs
TYPE PDZ RhoGEF

Cross References:
UniProt Q9ES67 EMBL AF225961
InterPro IPR000219 | IPR001331 | IPR001478 | IPR001849 | IPR011993 | IPR000342 | IPR015212 | IPR015721
GENEID 78966
PFAM PF00595 | PF09128 | PF00621

Details:
NAME PDZ RhoGEF-Rattus norvegicus
DESCRIPTION Rho guanine nucleotide exchange factor 11 (RhoGEF glutamate transportmodulator GTRAP48).
SPECIES Rattus norvegicus COMMON NAME Rat NCBI Taxonomy 10116
GENE Arhgef11
SEQUENCE 
MSIRLPHSIDRSASKKQSHLSSPIASWLSSLSSLGDSTPERTSPSHHRQPSDTSETTAGL
VQRCVIIQKDQHGFGFTVSGDRIVLVQSVRPGGAAMKAGVKEGDRIIKVNGTMVTNSSHL
EVVKLIKSGAYAALTLLGSSPPSVGVSGLQQNPSVAGVLRVNPIIPPPPPPPPLPPPQHI
TGPKPLQDPEVQKHATQILWNMLRQEEEELQDILPPCGETSQRTCEGRLSVDSQEADSGL
DSGTERFPSISESLM
 FRAGMENT NO
FUNCTION May play a role in the regulation of RhoA GTPase bys guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13)
Interacting with G-proteins:
Family:G12/13 REFERENCES:15251227 | 11799111 | 14607242
1GPR0036Galpha-12-Rattus norvegicus
Family:Gq/11 REFERENCES:1525227 | 16182515
2GPR0242Galpha-q-Rattus norvegicus

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