gpDB: a database of G-proteins and their interaction with GPCRs
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gpDB::GPCR View
Entry 1 of 1 :: GPCR2562 ::
CLASS CLASS A (RHODOPSIN LIKE)
FAMILY VASOPRESSIN AND OXYTOCIN RECEPTOR
SUBFAMILY V1A

Cross References:
UniProt P30560 | Q5M8D1 | Q62874 | Q9QW18 EMBL Z11690 | U39450 | BC088095
InterPro IPR015076 | IPR000276 GPCRDB v1ar_rat
GENEID 25107
PFAM PF00001 | PF08983

Details:
NAME VASOPRESSIN AND OXYTOCIN RECEPTOR_V1A_Rattus norvegicus
DESCRIPTION Vasopressin V1a receptor (V1aR) (Vascular/hepatic-type argininevasopressin receptor) (Antidiuretic hormone receptor 1a) (AVPR V1a).
SPECIES Rattus norvegicus COMMON NAME Rat NCBI Taxonomy 10116
GENE Avpr1a
SEQUENCE
MSFPRGSQDRSVGNSSPWWPLTTEGSNGSQEAARLGEGDSPLGDVRNEELAKLEIAVLAV
IFVVAVLGNSSVLLALHRTPRKTSRMHLFIRHLSLADLAVAFFQVLPQLCWDITYRFRGP
DWLCRVVKHLQVFAMFASAYMLVVMTADRYIAVCHPLKTLQQPARRSRLMIATSWVLSFI
LSTPQYFIFSVIEIEVNNGTKTQDCWATFIQPWGTRAYVTWMTSGVFVAPVVVLGTCYGF
ICYHIWRNIRGKTASSRHSKGDKGSGEAVGPFHKGLLVTPCVSSVKSISRAKIRTVKMTF
VIVSAYILCWAPFFIVQMWSVWDENFIWTDSENPSITITALLASLNSCCNPWIYMFFSGH
LLQDCVQSFPCCHSMAQKFAKDDSDSMSRRQTSYSNNRSPTNSTGMWKDSPKSSKSIRFI
PVST
FRAGMENT NO

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Dimerization:
HOMODIMER INFORMATION There is experimental evidence for homo-dimerization METHOD Bioluminescence Resonance Energy Transfer (BRET) REFERENCES 12554793
HETERODIMER INFORMATION Forms functional heterodimers with V2 Receptors METHOD Bioluminescence Resonance Energy Transfer (BRET) REFERENCES 12554793
HETERODIMER INFORMATION Forms functional heterodimers with OT Receptors METHOD Bioluminescence Resonance Energy Transfer (BRET) REFERENCES 12554793

Coupling with G-proteins:
Family:G12/13 REFERENCES:10364236
1GPR0036Galpha-12-Rattus norvegicus
Family:Gq/11 REFERENCES:1560825
2GPR0032Galpha-11-Rattus norvegicus
3GPR0242Galpha-q-Rattus norvegicus


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athina University of Athens
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Dept. of Cell Biology and Biophysics
Biophysics
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Laboratory