gpDB: a database of G-proteins and their interaction with GPCRs
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gpDB::GPCR View
Entry 1 of 1 :: GPCR0430 ::
CLASS CLASS A (RHODOPSIN LIKE)
FAMILY ANGIOTENSIN RECEPTOR
SUBFAMILY AT1

Cross References:
UniProt P29089 EMBL M87003 | X64052 | M90065 | S37461
InterPro IPR000190 | IPR000248 | IPR001186 | IPR000276 GPCRDB agtrb_rat
GENEID 81638
PRINTS PR00241 | PR00635 | PR00993 | PR00237 PFAM PF00001

Details:
NAME ANGIOTENSIN RECEPTOR_AT1_Rattus norvegicus-2
DESCRIPTION Type-1B angiotensin II receptor (AT1B) (AT3).
SPECIES Rattus norvegicus COMMON NAME Rat NCBI Taxonomy 10116
GENE Agtr1b | Agtr1 | At1b
SEQUENCE
MTLNSSTEDGIKRIQDDCPKAGRHNYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLK
TVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNHLCKIASASVSFNLYASVFLLT
CLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLMAGLASLPAVIYRNVYFIENTNITVC
AFHYESQNSTLPIGLGLTKNILGFVFPFLIILTSYTLIWKALKKAYKIQKNTPRNDDIFR
IIMAIVLFFFFSWVPHQIFTFLDVLIQLGIIRDCEIADIVDTAMPITICIAYFNNCLNPL
FYGFLGKKFKKYFLQLLKYIPPTAKSHAGLSTKMSTLSYRPSDNMSSSAKKSASFFEVE
FRAGMENT NO

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Dimerization:
HOMODIMER INFORMATION There is experimental evidence for homo-dimerization METHOD functional complementation REFERENCES 8576145
HETERODIMER INFORMATION Forms heterodimer with AT2 Receptor. After the dimerization the AT2 receptor antagonizes function of the AT1 receptor METHOD Immunoprecipitation REFERENCES 11507095
HETERODIMER INFORMATION Forms heterodimer with Bradykinin B2 Receptor. Dimerization results in increased signalling activity METHOD Immunoprecipitation REFERENCES 10993080

Scaffold:
TYPE eNOS( endothelial nitric oxide synthase) /cNOS/NOS3 REFERENCES 12842859
TYPE JAK2( Janus kinase) REFERENCES 9287353

Coupling with G-proteins:
Family:G12/13 REFERENCES:9092554 | 9287322
1GPR0036Galpha-12-Rattus norvegicus
Family:Gi/o REFERENCES:1310139
2GPR0026Galpha-o-Rattus norvegicus
3GPR0111Galpha-i3-Rattus norvegicus
4GPR0221Galpha-i1-Rattus norvegicus
5GPR0229Galpha-i2-Rattus norvegicus
Family:Gq/11 REFERENCES:8865167
6GPR0032Galpha-11-Rattus norvegicus
7GPR0242Galpha-q-Rattus norvegicus


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athina University of Athens
Faculty of Biology
Dept. of Cell Biology and Biophysics
Biophysics
& Bioinformatics
Laboratory