gpDB: a database of G-proteins and their interaction with GPCRs
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gpDB::G-protein View
Entry 1 of 1 :: GPR0027 ::
CLASS Galpha
FAMILY Gq/11
SUBFAMILY Galpha-11
TYPE Galpha-11

Cross References:
UniProt P38409 | Q2TA47 EMBL D90336 | BC111118
InterPro IPR001019 | IPR000654 | IPR011025
PRODOM PD000281
GENEID 281788
PRINTS PR00318 | PR00442 PFAM PF00503

Details:
NAME Galpha-11-Bos taurus
DESCRIPTION Guanine nucleotide-binding protein alpha-11 subunit (GL2).
SPECIES Bos taurus COMMON NAME Bovine NCBI Taxonomy 9913
POST TRANSLATION MODIFICATIONS null GENE GNA11
SEQUENCE 
MTLESMMACCLSDEVKESKRINAEIEKQLRRDKRDARRELKLLLLGTGESGKSTFIKQMR
IIHGAGYSEEDKRGFTKLVYQNIFTAMQAMIRAMETLKILYKYEQNKANALLIREVDVEK
VTTFEHRYVSAIKTLWNDPGIQECYDRRREYQLSDSAKYYLTDVDRIATSGYLPTQQDVL
RVRVPTTGIIEYPFDLENIIFRMVDVGGQRSERRKWIHCFENVTSIMFLVALSEYDQVLV
ESDNENRMEESKALFRTIVTYPWFQNSSVILFLNKKDLLEDKILHSHLVDYFPEFDGPQR
DAQAAREFILKMFVDLNPDSDKIIYSHFTCATDTENIRFVFAAVKDTILQLNLKEYNLV
 FRAGMENT NO
FUNCTION Guanine nucleotide-binding proteins (G proteins) ares involved as modulators or transducers in various transmembranes signaling systems
Effectors:
1EFF0347GRK2-Bos taurusInhibits PLC-beta activation and blocks Gqa-mediated GLUT4 translocation and glucose uptake in 3T3 adipocytes15251227 | 14654303 | 16182515
2EFF0357GRK3-Bos taurusStimulation15251227 | 14654303 | 16182515
3EFF0516Phospholipase C beta-1-Bos taurusStimulation of PLC-beta catalytic activity15251227 | 16182515 | 11015615
4EFF0554Phospholipase C beta-4-Bos taurusStimulation of PLC-beta catalytic activity15251227 | 16182515 | 11015615

Coupling with GPCRs:
1GPCR0211ADRENOCEPTOR (A1-ADRENOCEPTOR)_A1A(Adrenoceptor)_Bos taurus8396931
2GPCR0235ADRENOCEPTOR (A2-ADRENOCEPTOR)_A2A(Adrenoceptor)_Bos taurus8662784
3GPCR0416ANGIOTENSIN RECEPTOR_AT1_Bos taurus8865167
4GPCR0469BRADYKININ RECEPTOR_B2_Bos taurus1657928
5GPCR2637EXTRACELLULAR CALCIUM-SENSING RECEPTOR_CASR_Bos taurus8255296
6GPCR0740CHOLECYSTOKININ AND GASTRIN RECEPTOR_CCK2_Bos taurus1280419
7GPCR2429PROSTANOID RECEPTOR_EP3_Bos taurus11095474
8GPCR0816ENDOTHELIN RECEPTOR_ET-A_Bos taurus1849646
9GPCR0819ENDOTHELIN RECEPTOR_ET-B_Bos taurus1848367
10GPCR2442PROSTANOID RECEPTOR_FP_Bos taurus8300593
11GPCR0901GONADOTROPIN-RELEASING HORMONE RECEPTOR_GNRH1_Bos taurus1333190
12GPCR0969HISTAMINE RECEPTOR_H1_Bos taurus1722337
13GPCR1008LYSOPHOSPHOLIPID RECEPTOR_LPA1_Bos taurus9600933
14GPCR0868GLYCOPROTEIN HORMONE RECEPTOR_LSH RECEPTOR_Bos taurus-21516719
15GPCR0140ACETYLCHOLINE RECEPTOR (MUSCARINIC)_M3_Bos taurus11242080
16GPCR2499TACHYKININ RECEPTOR_NK1_Bos taurus1370820
17GPCR2505TACHYKININ RECEPTOR_NK2_Bos taurus1370820
18GPCR2558VASOPRESSIN AND OXYTOCIN RECEPTOR_OT_Bos taurus1313946
19GPCR2376P2Y RECEPTOR_P2Y1_Bos taurus8159738
20GPCR2622VASOACTIVE INTESTINAL PEPTIDE AND PITUITARY ADENYLATE CYCLASE ACTIVATING PEPTIDE RECEPTOR_PAC1_Bos taurus8396727
21GPCR2451PROSTANOID RECEPTOR_TP_Bos taurus8300593
22GPCR2521THYROTROPIN-RELEASING HORMONE RECEPTOR_TRH1_Bos taurus2175902
23GPCR0896GLYCOPROTEIN HORMONE RECEPTOR_TSH RECEPTOR_Bos taurus-18552586
24GPCR2550UROTENSIN RECEPTOR_UROTENSIN II RECEPTOR_Bos taurus10499587



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