gpDB: a database of G-proteins and their interaction with GPCRs
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gpDB::Effector View
Entry 1 of 1 :: EFF0516 ::
FAMILY Phospholipases C
SUBFAMILY Phospholipases C beta
TYPE Phospholipase C beta 1

Cross References:
UniProt P10894 EMBL J03137
InterPro IPR000008 | IPR011992 | IPR015359 | IPR013841 | IPR001192 | IPR000909 | IPR001711 | IPR014815
PRODOM PD001202 GENEID 287026
PRINTS PR00390 PFAM PF00168 | PF09279 | PF00388 | PF00387 | PF08703

Details:
NAME Phospholipase C beta-1-Bos taurus
DESCRIPTION 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-1(EC 3.1.4.11) (Phosphoinositide phospholipase C) (Phospholipase C-beta-1) (PLC-beta-1) (PLC-I) (PLC-154).
SPECIES Bos taurus COMMON NAME Bovine NCBI Taxonomy 9913
GENE PLCB1
SEQUENCE
MAGAQPGVHALQLKPVCVSDSLKKGTKFVKWEDDSTVVTPIILRTDPQGFFFYWTDQNKE
TELLDLSLVKDARCGKHAKAPKDPKLRELLDVGNIGRLEHRMITVVYGPDLVNISHLNLV
AFQEEVAKEWTNEVFSLATNLLAQNMSRDAFLEKAYTKLKLQVTPEGRIPLKNIYRLFSA
DRKRVETALEACSLPSSRNDSIPQEDFTPEVYRVFLNNLCPRPEIDNIFSEFGAKSKPYL
TVDQMMDFINLKQRD
FRAGMENT NO
FUNCTION The production of the second messenger moleculess diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) iss mediated by activated phosphatidylinositol-specific phospholipases C enzymes
Interacting with G-proteins:
Family:Gq/11 REFERENCES:15251227 | 16182515 | 11015615
1GPR0027Galpha-11-Bos taurus
2GPR0039Galpha-14-Bos taurus
Family:Gbeta REFERENCES:15251227 | 11015615 | 8383116
3GPR0145Gbeta-1-Bos taurus
4GPR0152Gbeta-2-Bos taurus
Family:Ggamma REFERENCES:15251227 | 11015615 | 8383116
5GPR0174Ggamma-t1-Bos taurus
6GPR0180Ggamma-2-Bos taurus
7GPR0182Ggamma-3-Bos taurus
8GPR0187Ggamma-5-Bos taurus
9GPR0191Ggamma-7-Bos taurus
10GPR0202Ggamma-12-Bos taurus
11GPR0209Ggamma-8-Bos taurus


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athina University of Athens
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Dept. of Cell Biology and Biophysics
Biophysics
& Bioinformatics
Laboratory