gpDB: a database of G-proteins and their interaction with GPCRs
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gpDB::GPCR View
Entry 1 of 1 :: GPCR0896 ::
CLASS CLASS A (RHODOPSIN LIKE)
FAMILY GLYCOPROTEIN HORMONE RECEPTOR
SUBFAMILY TSH RECEPTOR

Cross References:
UniProt Q27987 | Q27986 EMBL U15570 | U15568
InterPro IPR000276 | IPR002131 | IPR002274 GPCRDB tshr_bovin
GENEID 281553
PRINTS PR00373 | PR00237 | PR01145 PFAM PF00001

Details:
NAME GLYCOPROTEIN HORMONE RECEPTOR_TSH RECEPTOR_Bos taurus-1
DESCRIPTION Thyrotropin receptor precursor (TSH-R) (Thyroid-stimulating hormonereceptor).
SPECIES Bos taurus COMMON NAME Bovine NCBI Taxonomy 9913
GENE TSHR
SEQUENCE
MRPTPLLRLALFLVLPSSLGGERCPSPPCECRQEDDFRVTCKDIQSIPSLPPSTQTLKFI
ETHLKTIPSRAFSNLPNISRIYLSIDATLQQLESHSFYNLSKVTHIEIRNTRSLTYIDSG
ALKELPLLKFLGIFNTGLRVFPDLTKIYSTDVFFILEITDNPYMTSIPANAFQGLCNETL
TLKLYNNGFTSIQGHAFNGTKLDAVYLNKNKYLTVIGQDAFAGVYSGPTLLDISYTSVTA
LPSKGLEHLKELIARNTWTLRKLPLSLSFLHLTRADLSYPSHCCAFKNQKKIRGILQSLM
CNESSIRGLRQRKSASALNGPFYQEYEDLGDGSAGYKENSKFQDTQSNSHYYVFFEEQED
EIIGFGQQLKNPQEETLQAFDSHYDYTVCGGSEDMVCTPKSDEFNPCEDIMGYKFLRIVV
WFVSLLALLGNVFVLVILLTSHYKLTVPRFLMCNLAFADFCMGLYLLLIASVDLYTQSEY
YNHAIDWQTGPGCNTAGFFTVFASELSVYTLTVITLERWHAITFAMRLDRKIRLWHAYVI
MLGGWVCCFLLALLPLVGISSYAKVSICLPMDTETPLALAYIILVLLLNIIAFIIVCACY
VKIYITVRNPHYNPGDKDTRIAKRMAVLIFTDFMCMAPISFYALSALMNKPLITVTNSKI
LLVLFYPLNSCANPFLYAIFTKAFQRDVFMLLSKFGICKRQAQAYRGQRVSPKNSTGIRV
QKVPPDVRQSLPNVQDDYELLENSHLTPKQQDQTSKEYKRTVL
FRAGMENT NO

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Dimerization:
HOMODIMER INFORMATION There is experimental evidence for homo-dimerization METHOD Fluorescence Resonance Energy Transfer (FRET) REFERENCES 12223484

Coupling with G-proteins:
Family:Gi/o REFERENCES:8552586
1GPR0017Galpha-o1-Bos taurus
2GPR0219Galpha-i1-Bos taurus
3GPR0294Galpha-i2-Bos taurus-2
4GPR0295Galpha-i2-Bos taurus-1
Family:Gq/11 REFERENCES:8552586
5GPR0027Galpha-11-Bos taurus
Family:Gs REFERENCES:8552586
6GPR0114Galpha-s-Bos taurus


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athina University of Athens
Faculty of Biology
Dept. of Cell Biology and Biophysics
Biophysics
& Bioinformatics
Laboratory