gpDB: a database of G-proteins and their interaction with GPCRs
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gpDB::GPCR View
Entry 1 of 1 :: GPCR2637 ::
CLASS CLASS C (METABOTROPIC GLUTAMATE / PHEROMONE)
FAMILY EXTRACELLULAR CALCIUM-SENSING RECEPTOR
SUBFAMILY CASR

Cross References:
UniProt P35384 EMBL S67307
InterPro IPR001828 | IPR000337 | IPR015531 | IPR000068 | IPR011500 GPCRDB casr_bovin
GENEID 281038
PRINTS PR00592 | PR00248 PFAM PF00003 | PF01094 | PF07562

Details:
NAME EXTRACELLULAR CALCIUM-SENSING RECEPTOR_CASR_Bos taurus
DESCRIPTION Extracellular calcium-sensing receptor precursor (CaSR) (ParathyroidCell calcium-sensing receptor) (PCaR1).
SPECIES Bos taurus COMMON NAME Bovine NCBI Taxonomy 9913
GENE CASR | GPRC2A | PCAR1
SEQUENCE
MALYSCCWILLAFSTWCTSAYGPDQRAQKKGDIILGGLFPIHFGVAVKDQDLKSRPESVE
CIRYNFRGFRWLQAMIFAIEEINSSPALLPNMTLGYRIFDTCNTVSKALEATLSFVAQNK
IDSLNLDEFCNCSEHIPSTIAVVGATGSGISTAVANLLGLFYIPQVSYASSSRLLSNKNQ
FKSFLRTIPNDEHQATAMADIIEYFRWNWVGTIAADDDYGRPGIEKFREEAEERDICIDF
SELISQYSDEEKIQQVVEVIQNSTAKVIVVFSSGPDLEPLIKEIVRRNITGRIWLASEAW
ASSSLIAMPEYFHVVGGTIGFGLKAGQIPGFREFLQKVHPRKSVHNGFAKEFWEETFNCH
LQEGAKGPLPVDTFLRGHEEGGARLSNSPTAFRPLCTGEENISSVETPYMDYTHLRISYN
VYLAVYSIAHALQDIYTCIPGRGLFTNGSCADIKKVEAWQVLKHLRHLNFTSNMGEQVTF
DECGDLAGNYSIINWHLSPEDGSIVFKEVGYYNVYAKKGERLFINDEKILWSGFSREVPF
SNCSRDCLAGTRKGIIEGEPTCCFECVECPDGEYSDETDASACDKCPDDFWSNENHTSCI
AKEIEFLSWTEPFGIALTLFAVLGIFLTAFVLGVFIKFRNTPIVKATNRELSYLLLFSLL
CCFSSSLFFIGEPQDWTCRLRQPAFGISFVLCISCILVKTNRVLLVFEAKIPTSFHRKWW
GLNLQFLLVFLCTFMQIVICAIWLNTAPPSSYRNHELEDEIIFITCHEGSLMALGFLIGY
TCLLAAICFFFAFKSRKLPENFNEAKFITFSMLIFFIVWISFIPAYASTYGKFVSAVEVI
AILAASFGLLACIFFNKVYIILFKPSRNTIEEVRCSTAAHAFKVAARATLRRSNVSRQRS
SSLGGSTGSTPSSSISSKSNSEDPFPQQQPKRQKQPQPLALSPHNAQQPQPRPPSTPQPQ
PQSQQPPRCKQKVIFGSGTVTFSLSFDEPQKTAVAHRNSTHQTSLEAQKNNDALTKHQAL
LPLQCGETDSELTSQETGLQGPVGEDHQLEMEDPEEMSPALVVSNSRSFVISGGGSTVTE
NMLRS
FRAGMENT NO

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Dimerization:
HOMODIMER INFORMATION There is experimental evidence for homo-dimerization METHOD Bioluminescence Resonance Energy Transfer (BRET) REFERENCES 12383267
HOMODIMER INFORMATION There is experimental evidence for homo-dimerization METHOD Functional complementation of inactive mutant receptors REFERENCES 9722601
HOMODIMER INFORMATION There is experimental evidence for homo-dimerization METHOD Immunoprecipitation REFERENCES 10077597
HETERODIMER INFORMATION Forms heterodimers with Metabotropic Glutamate Receptor 1. METHOD Immunoprecipitation REFERENCES 11489900
HETERODIMER INFORMATION Forms heterodimers with Metabotropic Glutamate Receptor 5. METHOD Immunoprecipitation REFERENCES 11489900

Scaffold:
TYPE alpha-filamin/ABP280( actin binding protein 280) REFERENCES 11390380 | 1223909

Coupling with G-proteins:
Family:Gi/o REFERENCES:11152759
1GPR0017Galpha-o1-Bos taurus
2GPR0219Galpha-i1-Bos taurus
3GPR0294Galpha-i2-Bos taurus-2
4GPR0295Galpha-i2-Bos taurus-1
Family:Gq/11 REFERENCES:8255296
5GPR0027Galpha-11-Bos taurus


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athina University of Athens
Faculty of Biology
Dept. of Cell Biology and Biophysics
Biophysics
& Bioinformatics
Laboratory