gpDB: a database of G-proteins and their interaction with GPCRs
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gpDB::GPCR View
Entry 1 of 1 :: GPCR0140 ::
CLASS CLASS A (RHODOPSIN LIKE)
FAMILY ACETYLCHOLINE RECEPTOR (MUSCARINIC)
SUBFAMILY M3

Cross References:
UniProt P41984 EMBL U08286 | L27103
InterPro IPR000276 | IPR001183 | IPR000995 GPCRDB acm3_bovin
GENEID 281685
PRINTS PR00237 | PR00243 | PR00540 PFAM PF00001

Details:
NAME ACETYLCHOLINE RECEPTOR (MUSCARINIC)_M3_Bos taurus
DESCRIPTION Muscarinic acetylcholine receptor M3.
SPECIES Bos taurus COMMON NAME Bovine NCBI Taxonomy 9913
GENE CHRM3
SEQUENCE
MTLHNNNTTSPLFPNISSSWIHGPSDTGLPPGTVTHFGSYNISRAAGNLSSPNGTTSDPL
GGHTIWQVVFIAFLTGVLALVTIIGNILVIVAFKVNKQLKTVNNYFLLSLACADLIIGVI
SMNLFTTYIIMNRWALGNLACDLWLSIDYVASNASVMNLLVISFDRYFSITRPLTYRAKR
TTKRAGVMIGLAWVISFILWAPAILFWQYFVGKRTVPPGECFIQFLSEPTITFGTAIAAF
YMPVTIMTILYWRIYKETEKRTKELAGLQASGTEAEAENFVHPTGSSRSCSSYELQQQSM
KRSARRKYGRCHFWFTTKSWKPSAEQMDQDHSSSDSWNNNDAAASLENSASSDEEDIGSE
TRAIYSIVLKLPGHSTILNSTKLPSSDNLQVPEEELGSVGLERKPSKLQTQQSMDDGGSF
QKSFSKLPIQLESAVDTAKASDVNSSVGKTTATLPLSFKEATLAKRFALKTRSQITKRKR
MSLIKEKKAAQTLSAILLAFIITWTPYNIMVLVNTFCDSCIPKTYWNLGYWLCYINSTVN
PVCYALCNKTFRNTFKMLLLCQCDKRKRRKQQYQQRQSVIFHKRVPEQAL
FRAGMENT NO

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Dimerization:
HOMODIMER INFORMATION There is experimental evidence for homo-dimerization METHOD Immunoprecipitation REFERENCES 10383466
HETERODIMER INFORMATION Forms heterodimers with Muscarinic M2 Receptors. Heterodimerization results in altered internalization of the receptors METHOD Chimeric receptor reconstitution studies REFERENCES 10490911

Coupling with G-proteins:
Family:Gq/11 REFERENCES:11242080
1GPR0027Galpha-11-Bos taurus


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athina University of Athens
Faculty of Biology
Dept. of Cell Biology and Biophysics
Biophysics
& Bioinformatics
Laboratory