gpDB: a database of G-proteins and their interaction with GPCRs
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gpDB::G-protein View
Entry 1 of 1 :: GPR0114 ::
CLASS Galpha
FAMILY Gs
SUBFAMILY Galpha-s
TYPE Galpha-s

Cross References:
UniProt P04896 | Q0II85 | Q3SZE7 EMBL X03404 | M13006 | BC102905 | BC122757 | M14014
InterPro IPR001019 | IPR000367 | IPR011025 PDB 1AZS | 1AZT | 1CJK | 1CJT | 1CJU | 1CJV | 1CS4 | 1CUL | 1TL7 | 1U0H | 2GVD | 2GVZ
PRODOM PD000281
GENEID 281793
PRINTS PR00318 | PR00443 PFAM PF00503

Details:
NAME Galpha-s-Bos taurus
DESCRIPTION Guanine nucleotide-binding protein G(s) subunit alpha isoforms short(Adenylate cyclase-stimulating G alpha protein).
SPECIES Bos taurus COMMON NAME Bovine NCBI Taxonomy 9913
POST TRANSLATION MODIFICATIONS null GENE GNAS | GNAS1
SEQUENCE
MGCLGNSKTEDQRNEEKAQREANKKIEKQLQKDKQVYRATHRLLLLGAGESGKSTIVKQM
RILHVNGFNGEGGEEDPQAARSNSDGEKATKVQDIKNNLKEAIETIVAAMSNLVPPVELA
NPENQFRVDYILSVMNVPDFDFPPEFYEHAKALWEDEGVRACYERSNEYQLIDCAQYFLD
KIDVIKQDDYVPSDQDLLRCRVLTSGIFETKFQVDKVNFHMFDVGGQRDERRKWIQCFND
VTAIIFVVASSSYNMVIREDNQTNRLQEALNLFKSIWNNRWLRTISVILFLNKQDLLAEK
VLAGKSKIEDYFPEFARYTTPEDATPEPGEDPRVTRAKYFIRDEFLRISTASGDGRHYCY
PHFTCAVDTENIRRVFNDCRDIIQRMHLRQYELL
FRAGMENT NO
FUNCTION Guanine nucleotide-binding proteins (G proteins) ares involved as modulators or transducers in various transmembranes signaling systems
Effectors:
1EFF0001Adenylate cyclase-1-Bos taurusStimulation15251227 | 15922020 | 14993377 | 11376933
2EFF0044Adenylate cyclase-7-Bos taurusStimulation15251227 | 15922020 | 14993377 | 11376933
3EFF0947Tubulin-Bos taurus-1Stimulation of GTPase activity10224115 | 15251227 | 16380086
4EFF0948Tubulin-Bos taurus-2Stimulation of GTPase activity10224115 | 15251227 | 16380086
5EFF0949Tubulin-Bos taurus-3Stimulation of GTPase activity10224115 | 15251227 | 16380086
6EFF0950Tubulin-Bos taurus-4Stimulation of GTPase activity10224115 | 15251227 | 16380086
7EFF0951Tubulin-Bos taurus-5Stimulation of GTPase activity10224115 | 15251227 | 16380086
8EFF0952Tubulin-Bos taurus-6Stimulation of GTPase activity10224115 | 15251227 | 16380086
9EFF0953Tubulin-Bos taurus-7Stimulation of GTPase activity10224115 | 15251227 | 16380086

Coupling with GPCRs:
1GPCR0235ADRENOCEPTOR (A2-ADRENOCEPTOR)_A2A(Adrenoceptor)_Bos taurus8662784
2GPCR0309ADRENOCEPTOR (B-ADRENOCEPTOR)_B1(Adrenoceptor)_Bos taurus2825170
3GPCR0330ADRENOCEPTOR (B-ADRENOCEPTOR)_B2(Adrenoceptor)_Bos taurus3041227
4GPCR0397ADRENOCEPTOR (B-ADRENOCEPTOR)_B3(Adrenoceptor)_Bos taurus2570461
5GPCR0771DOPAMINE RECEPTOR_D1_Bos taurus-12144334
6GPCR0804DOPAMINE RECEPTOR_D5_Bos taurus1831904
7GPCR2429PROSTANOID RECEPTOR_EP3_Bos taurus11095474
8GPCR0816ENDOTHELIN RECEPTOR_ET-A_Bos taurus1849646
9GPCR0855GLYCOPROTEIN HORMONE RECEPTOR_FSH RECEPTOR_Bos taurus9139796
10GPCR2445PROSTANOID RECEPTOR_IP_Bos taurus7512962
11GPCR0868GLYCOPROTEIN HORMONE RECEPTOR_LSH RECEPTOR_Bos taurus-21516719
12GPCR1159MELANOCORTIN RECEPTOR_MC1_Bos taurus-11516719
13GPCR1162MELANOCORTIN RECEPTOR_MC1_Bos taurus-21516719
14GPCR1179MELANOCORTIN RECEPTOR_MC1_Bos taurus-31516719
15GPCR1185MELANOCORTIN RECEPTOR_MC2_Bos taurus1325670
16GPCR1199MELANOCORTIN RECEPTOR_MC4_Bos taurus8392067
17GPCR1205MELANOCORTIN RECEPTOR_MC5_Bos taurus8185570
18GPCR2499TACHYKININ RECEPTOR_NK1_Bos taurus1370820
19GPCR2505TACHYKININ RECEPTOR_NK2_Bos taurus1370820
20GPCR2622VASOACTIVE INTESTINAL PEPTIDE AND PITUITARY ADENYLATE CYCLASE ACTIVATING PEPTIDE RECEPTOR_PAC1_Bos taurus8396727
21GPCR0896GLYCOPROTEIN HORMONE RECEPTOR_TSH RECEPTOR_Bos taurus-18552586
22GPCR2566VASOPRESSIN AND OXYTOCIN RECEPTOR_V2_Bos taurus1534150




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