gpDB: a database of G-proteins and their interaction with GPCRs
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gpDB::Effector View
Entry 1 of 1 :: EFF0001 ::
FAMILY Cyclases
SUBFAMILY Adenylate cyclases
TYPE Adenylate cyclase 1

Cross References:
UniProt P19754 EMBL M25579
InterPro IPR001054 PDB 1AWK
GENEID 281601
PFAM PF00211

Details:
NAME Adenylate cyclase-1-Bos taurus
DESCRIPTION Adenylate cyclase type 1 (EC 4.6.1.1) (Adenylate cyclase type I) (ATPpyrophosphate-lyase 1) (Adenylyl cyclase 1) (Ca(2+)/calmodulin-activated adenylyl cyclase).
SPECIES Bos taurus COMMON NAME Bovine NCBI Taxonomy 9913
GENE ADCY1
SEQUENCE 
MAGAPRGRGGGGGGGGAGESGGAERAAGPGGRRGLRACDEEFACPELEALFRGYTLRLEQ
AATLKALAVLSLLAGALALAELLGAPGPAPGLAKGSHPVHCVLFLALLVVTNVRSLQVPQ
LQQVGQLALLFSLTFALLCCPFALGGPAGAHAGAAAVPATADQGVWQLLLVTFVSYALLP
VRSLLAIGFGLVVAASHLLVTATLVPAKRPRLWRTLGANALLFLGVNVYGIFVRILAERA
QRKAFLQARNCIEDR
 FRAGMENT NO
FUNCTION This is a calmodulin-sensitive adenylyl cyclase
Interacting with G-proteins:
Family:Gi/o REFERENCES:15251227 | 15922020 | 14993377 | 11376933
1GPR0219Galpha-i1-Bos taurus
2GPR0294Galpha-i2-Bos taurus-2
3GPR0295Galpha-i2-Bos taurus-1
4GPR0017Galpha-o1-Bos taurus
Family:Gs REFERENCES:15251227 | 15922020 | 14993377 | 11376933
5GPR0114Galpha-s-Bos taurus
Family:Gbeta REFERENCES:15251227 | 15922020 | 14993377 | 11376933 | 10449730
6GPR0145Gbeta-1-Bos taurus
7GPR0152Gbeta-2-Bos taurus
Family:Ggamma REFERENCES:15251227 | 15922020 | 14993377 | 11376933 | 10449730
8GPR0174Ggamma-t1-Bos taurus
9GPR0180Ggamma-2-Bos taurus
10GPR0182Ggamma-3-Bos taurus
11GPR0187Ggamma-5-Bos taurus
12GPR0191Ggamma-7-Bos taurus
13GPR0202Ggamma-12-Bos taurus
14GPR0209Ggamma-8-Bos taurus

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athina University of Athens
 Faculty of Biology
 Dept. of Cell Biology and Biophysics
Biophysics
& Bioinformatics
Laboratory