gpDB: a database of G-proteins and their interaction with GPCRs
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gpDB::GPCR View
Entry 1 of 1 :: GPCR0771 ::
CLASS CLASS A (RHODOPSIN LIKE)
FAMILY DOPAMINE RECEPTOR
SUBFAMILY D1

Cross References:
UniProt Q95136 | A4IFG9 | Q8WND7 EMBL AF381032 | BC134576 | U73042
InterPro IPR015694 | IPR001413 | IPR000929 | IPR000276 GPCRDB drd1_bovin
GENEID 281125
PRINTS PR00565 | PR00242 | PR00237 PFAM PF00001

Details:
NAME DOPAMINE RECEPTOR_D1_Bos taurus-1
DESCRIPTION D(1A) dopamine receptor.
SPECIES Bos taurus COMMON NAME Bovine NCBI Taxonomy 9913
GENE DRD1 | D1AR
SEQUENCE
MRTLNTSTMEGTGLVAERDFSFRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTN
FFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGSFCNIWVAFDIMCSTASILNLCVISVD
RYWAISSPFRYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTGPSEGNATSLG
KTINNCDSSLSRTYAISSSLISFYIPVAIMIVTYTRIYRIAQKQIRRISALERAAVHAKN
CQTTTGNGNPMECSQPESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFILNCMVPFCGS
GETKPFCIDSITFDVFVWFGWANSSLNPIIYAFNADFRKAFSTLLGCYRLCPTTNNAIET
VSINNNGAVVFSSHHEPRGSISKDCNVVYLIPHAVGSSEGLKKEEAVGIAKPLEKLSPAL
SVILDYDTDVSLEKIQPITQNGQHPT
FRAGMENT NO

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Dimerization:
HOMODIMER INFORMATION There is experimental evidence for homo-dimerization METHOD Immunoprecipitation REFERENCES 9804783
HETERODIMER INFORMATION Forms heterodimers with Adenosine A1 Receptor. Heterodimerization results in altered D1 receptor signalling METHOD Immunoprecipitation REFERENCES 10890919

Coupling with G-proteins:
Family:Gs REFERENCES:2144334
1GPR0114Galpha-s-Bos taurus


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athina University of Athens
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Dept. of Cell Biology and Biophysics
Biophysics
& Bioinformatics
Laboratory