gpDB: a database of G-proteins and their interaction with GPCRs
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gpDB::G-protein View
Entry 1 of 1 :: GPR0223 ::
CLASS Galpha
FAMILY Gi/o
SUBFAMILY Galpha-i
TYPE Galpha-i2

Cross References:
UniProt P38400 EMBL AY563036
InterPro IPR001019 | IPR001408 | IPR011025
PRODOM PD000281
GENEID 442957
PRINTS PR00318 | PR00441 PFAM PF00503

Details:
NAME Galpha-i2-Canis familiaris
DESCRIPTION Guanine nucleotide-binding protein G(i), alpha-2 subunit (Adenylatecyclase-inhibiting G alpha protein).
SPECIES Canis familiaris COMMON NAME Dog NCBI Taxonomy 9615
POST TRANSLATION MODIFICATIONS null GENE GNAI2
SEQUENCE 
MGCTVSAEDKAAAERSKMIDKNLREDGEKAAREVKLLLLGAGESGKSTIVKQMKIIHEDG
YSEEECRQYRAVVYSNTIQSIMAIVKAMGNLQIDFDDPSRADDARQLFALSCTAEEQGVL
PEDLSCVIRRLWADNGVQACFGRSREYQLNDSAAYYLNDLERIAQSDYIPTQQDVLRTRV
KTTGIVETHFTFKDLHFKMFDVGGQRSERKKWIHCFEGVTAIIFCVALSAYDLVLAEDEE
MNRMHESMKLFDSICNNKWFTDTSIILFLNKKDLFEEKITHSPLTICFPEYTGANKYEEA
ASYIQSKFEDLNKRKDTKEIYTHFTCATDTKNVQFVFDAVTDVIIKNNLKDCGLF
 FRAGMENT NO
FUNCTION Guanine nucleotide-binding proteins (G proteins) ares involved as modulators or transducers in various transmembranes signaling systems
Effectors:
1EFF0028Adenylate cyclase-5-Canis familiarisInhibition15251227 | 15922020 | 14993377 | 11376933
2EFF0038Adenylate cyclase-6-Canis familiarisInhibition15251227 | 15922020 | 14993377 | 11376933
3EFF0619Rac-Canis familiarisStimulation11099498
4EFF1010Tubulin-Canis familiaris-1Stimulation of GTPase activity10224115 | 15251227 | 16380086
5EFF1011Tubulin-Canis familiaris-2Stimulation of GTPase activity10224115 | 15251227 | 16380086

Coupling with GPCRs:
1GPCR00255-HYDROXYTRYPTAMINE RECEPTOR_5-HT-1B_Canis familiaris1351684
2GPCR00465-HYDROXYTRYPTAMINE RECEPTOR_5-HT-1D_Canis familiaris1565658
3GPCR0174ADENOSINE RECEPTOR_A1_Canis familiaris1662665
4GPCR0195ADENOSINE RECEPTOR_A3_Canis familiaris1323836
5GPCR0424ANGIOTENSIN RECEPTOR_AT1_Canis familiaris-21310139
6GPCR0427ANGIOTENSIN RECEPTOR_AT1_Canis familiaris-11310139
7GPCR0396ADRENOCEPTOR (B-ADRENOCEPTOR)_B3(Adrenoceptor)_Canis familiaris9363896
8GPCR0716CHEMOTACTIC PEPTIDE RECEPTOR_C5A_Canis familiaris7887933
9GPCR0536CANNABINOID RECEPTOR_CB1_Canis familiaris2165569
10GPCR0618CHEMOKINE RECEPTOR (CX3C)_CXCR1_Canis familiaris9390561
11GPCR0777DOPAMINE RECEPTOR_D2_Canis familiaris-32974511
12GPCR0781DOPAMINE RECEPTOR_D2_Canis familiaris-12974511
13GPCR0785DOPAMINE RECEPTOR_D2_Canis familiaris-22974511
14GPCR0821ENDOTHELIN RECEPTOR_ET-B_Canis familiaris1848367
15GPCR0875GLYCOPROTEIN HORMONE RECEPTOR_LSH RECEPTOR_Canis familiaris1516719
16GPCR1035LYSOPHOSPHOLIPID RECEPTOR_S1P1_Canis familiaris9488656
17GPCR0880GLYCOPROTEIN HORMONE RECEPTOR_TSH RECEPTOR_Canis familiaris8552586
18GPCR1251NEUROPEPTIDE Y RECEPTOR_Y1_Canis familiaris1321422
19GPCR1270NEUROPEPTIDE Y RECEPTOR_Y5_Canis familiaris8700207



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