gpDB: a database of G-proteins and their interaction with GPCRs
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gpDB::GPCR View
Entry 1 of 1 :: GPCR0880 ::
CLASS CLASS A (RHODOPSIN LIKE)
FAMILY GLYCOPROTEIN HORMONE RECEPTOR
SUBFAMILY TSH RECEPTOR

Cross References:
UniProt P14763 EMBL X17146 | X17147 | M29957 | M90047
InterPro IPR000276 | IPR002131 | IPR001611 | IPR002274 GPCRDB tshr_canfa
GENEID 403968
PRINTS PR00373 | PR00237 | PR01145 PFAM PF00001 | PF00560

Details:
NAME GLYCOPROTEIN HORMONE RECEPTOR_TSH RECEPTOR_Canis familiaris
DESCRIPTION Thyrotropin receptor precursor (TSH-R) (Thyroid-stimulating hormonereceptor).
SPECIES Canis familiaris COMMON NAME Dog NCBI Taxonomy 9615
GENE TSHR
SEQUENCE
MRPPPLLHLALLLALPRSLGGKGCPSPPCECHQEDDFRVTCKDIHRIPTLPPSTQTLKFI
ETQLKTIPSRAFSNLPNISRIYLSIDATLQRLESHSFYNLSKMTHIEIRNTRSLTSIDPD
ALKELPLLKFLGIFNTGLGVFPDVTKVYSTDVFFILEITDNPYMASIPANAFQGLCNETL
TLKLYNNGFTSIQGHAFNGTKLDAVYLNKNKYLSAIDKDAFGGVYSGPTLLDVSYTSVTA
LPSKGLEHLKELIARNTWTLKKLPLSLSFLHLTRADLSYPSHCCAFKNQKKIRGILESLM
CNESSIRSLRQRKSVNTLNGPFDQEYEEYLGDSHAGYKDNSQFQDTDSNSHYYVFFEEQE
DEILGFGQELKNPQEETLQAFDSHYDYTVCGGNEDMVCTPKSDEFNPCEDIMGYKFLRIV
VWFVSLLALLGNVFVLIVLLTSHYKLTVPRFLMCNLAFADFCMGMYLLLIASVDLYTHSE
YYNHAIDWQTGPGCNTAGFFTVFASELSVYTLTVITLERWYAITFAMRLDRKIRLRHAYA
IMVGGWVCCFLLALLPLVGISSYAKVSICLPMDTETPLALAYIILVLLLNIVAFIIVCSC
YVKIYITVRNPQYNPGDKDTKIAKRMAVLIFTDFMCMAPISFYALSALMNKPLITVTNSK
ILLVLFYPLNSCANPFLYAIFTKAFQRDVFILLSKFGICKRQAQAYRGQRVSPKNSAGIQ
IQKVTRDMRQSLPNMQDEYELLENSHLTPNKQGQISKEYNQTVL
FRAGMENT NO

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Dimerization:
HOMODIMER INFORMATION There is experimental evidence for homo-dimerization METHOD Fluorescence Resonance Energy Transfer (FRET) REFERENCES 12223484

Coupling with G-proteins:
Family:Gi/o REFERENCES:8552586
1GPR0223Galpha-i2-Canis familiaris
Family:Gq/11 REFERENCES:8552586
2GPR0233Galpha-q-Canis familiaris
Family:Gs REFERENCES:8552586
3GPR0120Galpha-s-Canis familiaris


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athina University of Athens
Faculty of Biology
Dept. of Cell Biology and Biophysics
Biophysics
& Bioinformatics
Laboratory